Klra3 killer cell lectin-like receptor, subfamily A, member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Klra3provided by MGI
Official Full Name: killer cell lectin-like receptor, subfamily A, member 3provided by MGI
Primary source: MGI:MGI:101905
See related: Ensembl:ENSMUSG00000067591 AllianceGenome:MGI:101905
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 5E6; Nk2; Nk-2; Ly49c; Nk2.1; NK-2.1
Summary: Predicted to enable signaling receptor activity. Predicted to be involved in regulation of signal transduction. Predicted to be located in plasma membrane. Predicted to be active in cell surface. [provided by Alliance of Genome Resources, Oct 2024]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 6 F3; 6 63.44 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (130300252..130314589, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (130323289..130337626, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dynamic allostery controls the peptide sensitivity of the Ly49C natural killer receptor.
Title: Dynamic allostery controls the peptide sensitivity of the Ly49C natural killer receptor.
The Ly49 family of class I MHC receptors have critical role for adaptive natural killer cell responses.
Title: Critical role for the Ly49 family of class I MHC receptors in adaptive natural killer cell responses.
Clearance of lung cancer is facilitated by up-regulation of NKG2D, NKp46, and other activating receptors upon exposure to environmental MHCI. Surface expression of the inhibitory receptor Ly49C/I, on the other hand, is down-regulated upon exposure to tumor-bearing tissue.
Title: Modulation of NKG2D, NKp46, and Ly49C/I facilitates natural killer cell-mediated control of lung cancer.
This docking mode was conserved with that previously observed for Ly49C.H-2K(b) Indeed, structure-guided mutation of Ly49C indicated that Ly49C.H2-Q10 and Ly49C.H-2K(b) possess similar energetic footprints focused around residues located within the Ly49C beta4-stand and L5 loop, which contact the underside of the peptide-binding platform floor.
Title: Recognition of the Major Histocompatibility Complex (MHC) Class Ib Molecule H2-Q10 by the Natural Killer Cell Receptor Ly49C.
murine cytomegalovirus infection results in altered NK cell activation
Title: Ly49C-dependent control of MCMV Infection by NK cells is cis-regulated by MHC Class I molecules.
we have shown for the first time how the differential expression of the Ly49 inhibitory receptors during ontogeny can affect NK cell function
Title: Cutting edge: Ly49C/I⁻ neonatal NK cells predispose newborns to autoimmune ovarian disease induced by maternal autoantibody.
This study showed that mPer2 is a critical clock component in modulating circadian rhythms in bone marrow, and it implies that Ly49C and Nkg2d may play an important role in mediating mPer2-controlled cytotoxic response.
Title: Expression profiling reveals a positive regulation by mPer2 on circadian rhythm of cytotoxicity receptors: Ly49C and Nkg2d.
adoptive infusion of alloreactive NK cells with silenced Ly49C gene results in suppression of graft-versus-host disease
Title: Suppression of graft-versus-host disease after adoptive infusion of alloreactive NK cells induced by silencing Ly49C gene in mice.
signaling through the mouse NK inhibitory receptor Ly49C requires the presence of H-2Kb and this signaling is prevented when H-2Kb is ablated by pulsing with a peptide that can bind to it with high affinity
Title: Influence of xenogeneic beta2-microglobulin on functional recognition of H-2Kb by the NK cell inhibitory receptor Ly49C.
The repertoire of inhibitory Ly49 receptors may be formed under the influenced of Fyn-dependent NK cell activation as well as the respective MHC class I environment.
Title: A role for the src family kinase Fyn in NK cell activation and the formation of the repertoire of Ly49 receptors.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation
Not Applicable (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Klra3 (e-PCR), detects polymorphism
- UniSTS:143709

Klra3 (e-PCR), detects polymorphism
- UniSTS:143710

Klra3 (e-PCR), detects polymorphism
- UniSTS:143711

NoName (e-PCR)
- UniSTS:489079

NoName (e-PCR)
- UniSTS:489146

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: killer cell lectin-like receptor 3

Names: T-cell surface glycoprotein Ly-49C; lymphocyte antigen 49c; natural killer cell-associated antigen 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289604.1 → NP_001276533.1 killer cell lectin-like receptor 3

See identical proteins and their annotated locations for NP_001276533.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate exon structure in the 3' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.

Source sequence(s)

AC087336

Consensus CDS

CCDS20601.1

UniProtKB/Swiss-Prot

Q3TWQ1, Q3ZB40, Q499I4, Q61154, Q61198, Q64257, Q64329

UniProtKB/TrEMBL

Q9JHN9

Related

ENSMUSP00000085333.5, ENSMUST00000088017.5

Conserved Domains (2) summary

cd03593
Location:145 → 259

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

pfam08391
Location:40 → 157

Ly49; Ly49-like protein, N-terminal region
NM_001289605.1 → NP_001276534.1 killer cell lectin-like receptor 3

See identical proteins and their annotated locations for NP_001276534.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR and contains an alternate exon structure in the 3' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.

Source sequence(s)

AC087336

Consensus CDS

CCDS20601.1

UniProtKB/Swiss-Prot

Q3TWQ1, Q3ZB40, Q499I4, Q61154, Q61198, Q64257, Q64329

UniProtKB/TrEMBL

Q9JHN9

Conserved Domains (2) summary

cd03593
Location:145 → 259

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

pfam08391
Location:40 → 157

Ly49; Ly49-like protein, N-terminal region
NM_010648.3 → NP_034778.2 killer cell lectin-like receptor 3

See identical proteins and their annotated locations for NP_034778.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.

Source sequence(s)

AC087336, AK159595, BX515458, U56404

Consensus CDS

CCDS20601.1

UniProtKB/Swiss-Prot

Q3TWQ1, Q3ZB40, Q499I4, Q61154, Q61198, Q64257, Q64329

UniProtKB/TrEMBL

Q9JHN9

Related

ENSMUSP00000107629.3, ENSMUST00000111998.9

Conserved Domains (2) summary

cd03593
Location:145 → 259

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

pfam08391
Location:40 → 157

Ly49; Ly49-like protein, N-terminal region