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    CALML6 calmodulin like 6 [ Homo sapiens (human) ]

    Gene ID: 163688, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CALML6provided by HGNC
    Official Full Name
    calmodulin like 6provided by HGNC
    Primary source
    HGNC:HGNC:24193
    See related
    Ensembl:ENSG00000169885 MIM:610171; AllianceGenome:HGNC:24193
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAGLP
    Summary
    Predicted to enable calcium ion binding activity and enzyme regulator activity. Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    all
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    Genomic context

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    See CALML6 in Genome Data Viewer
    Location:
    1p36.33
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (1915260..1917296)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (1348173..1351716)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1846699..1848735)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 93 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 94 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 95 Neighboring gene GNB1 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 96 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 97 Neighboring gene uncharacterized LOC124903822 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 45 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 98 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1840895-1841864 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1845520-1846206 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1850035-1850836 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1850896-1851489 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1851490-1852082 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:1853696-1853880 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1854781-1855281 Neighboring gene transmembrane protein 52 Neighboring gene cilia and flagella associated protein 74 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:1871092-1871328 Neighboring gene uncharacterized LOC107984872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1889089-1889729 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1889730-1890369

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of human CAGLP gene encoding a novel EF-hand protein. Chen S, et al. DNA Seq, 2004 Oct-Dec. PMID 15621662
    2. EP4-induced mitochondrial localization and cell migration mediated by CALML6 in human oral squamous cell carcinoma. Ishikawa S, et al. Commun Biol, 2024 May 14. PMID 38745046, Free PMC Article
    3. The EF-Hand Protein CALML6 Suppresses Antiviral Innate Immunity by Impairing IRF3 Dimerization. Wang Z, et al. Cell Rep, 2019 Jan 29. PMID 30699354
    4. CALML6 Controls TAK1 Ubiquitination and Confers Protection against Acute Inflammation. Sheng C, et al. J Immunol, 2020 Jun 1. PMID 32303555
    5. Proteomic analysis of GTP cyclohydrolase 1 multiprotein complexes in cultured normal adult human astrocytes under both basal and cytokine-activated conditions. Chiarini A, et al. Proteomics, 2009 Apr. PMID 19294699

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. EP4-induced mitochondrial localization and cell migration mediated by CALML6 in human oral squamous cell carcinoma.
      Title: EP4-induced mitochondrial localization and cell migration mediated by CALML6 in human oral squamous cell carcinoma.
    2. The EF-hand protein calmodulin-like 6 (CALML6) directly bound to the phosphorylated serine-rich (SR) region of IRF3 and impaired its dimerization and nuclear translocation.
      Title: The EF-Hand Protein CALML6 Suppresses Antiviral Innate Immunity by Impairing IRF3 Dimerization.
    3. a novel human gene, CAGLP (calglandulin-like protein) was predicted, and subsequently isolated from human skeleton muscle
      Title: Cloning and characterization of human CAGLP gene encoding a novel EF-hand protein.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables enzyme regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    calmodulin-like protein 6
    Names
    EF-hand protein
    calglandulin-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330313.2 → NP_001317242.1  calmodulin-like protein 6 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AL109917
      Consensus CDS
      CCDS81255.1
      UniProtKB/TrEMBL
      B1AKR1
      Related
      ENSP00000367867.3, ENST00000378604.3

    2. NM_138705.4 → NP_619650.2  calmodulin-like protein 6 isoform 1

      See identical proteins and their annotated locations for NP_619650.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF490905, AL109917
      Consensus CDS
      CCDS30566.1
      UniProtKB/Swiss-Prot
      A2A2M3, Q6Q2C4, Q8TD86
      Related
      ENSP00000304643.3, ENST00000307786.8
      Conserved Domains (2) summary
      PTZ00184
      Location:26 → 173
      PTZ00184; calmodulin; Provisional
      cd00051
      Location:111 → 173
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      1915260..1917296
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005244729.4 → XP_005244786.2  calmodulin-like protein 6 isoform X1

      Conserved Domains (2) summary
      PTZ00184
      Location:48 → 195
      PTZ00184; calmodulin; Provisional
      cd00051
      Location:133 → 195
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      1348173..1351716
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334736.1 → XP_054190711.1  calmodulin-like protein 6 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TD86.2 GenPept UniProtKB/Swiss-Prot:Q8TD86

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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