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    Inha inhibin alpha [ Mus musculus (house mouse) ]

    Gene ID: 16322, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Inhaprovided by MGI
    Official Full Name
    inhibin alphaprovided by MGI
    Primary source
    MGI:MGI:96569
    See related
    Ensembl:ENSMUSG00000032968 AllianceGenome:MGI:96569
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate multiple peptide products, including the alpha subunit of the inhibin A and B protein complexes. These complexes negatively regulate follicle stimulating hormone secretion from the pituitary gland. Inhibins have also been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion. Mice in which this gene has been ablated exhibit sex cord-stromal tumors and symptoms that mimic the human cancer cachexia syndrome. [provided by RefSeq, Aug 2016]
    Expression
    Biased expression in ovary adult (RPKM 2254.3) and adrenal adult (RPKM 71.2) See more
    Orthologs
    human all
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    Genomic context

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    See Inha in Genome Data Viewer
    Location:
    1 C4; 1 39.16 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (75483872..75487010)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (75507077..75510366)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene chondroitin polymerizing factor Neighboring gene transmembrane protein 198 Neighboring gene obscurin-like 1 Neighboring gene STARR-seq mESC enhancer starr_01360 Neighboring gene STARR-positive B cell enhancer ABC_E5772 Neighboring gene STARR-positive B cell enhancer ABC_E5773 Neighboring gene STARR-positive B cell enhancer ABC_E4325 Neighboring gene serine/threonine kinase 11 interacting protein Neighboring gene predicted gene 15183

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of an inhibin receptor in gonadal tumors from inhibin alpha-subunit knockout mice. Draper LB, et al. J Biol Chem, 1998 Jan 2. PMID 9417095
    2. Characterization of the mechanism of inhibin α-subunit gene in mouse anterior pituitary cells by RNA interference. Han L, et al. PLoS One, 2013. PMID 24098340, Free PMC Article
    3. Transgenic models to study the roles of inhibins and activins in reproduction, oncogenesis, and development. Matzuk MM, et al. Recent Prog Horm Res, 1996. PMID 8701077
    4. The mouse inhibin alpha-subunit promoter directs SV40 T-antigen to Leydig cells in transgenic mice. Kananen K, et al. Mol Cell Endocrinol, 1996 May 31. PMID 8807633
    5. Action mechanism of inhibin α-subunit on the development of Sertoli cells and first wave of spermatogenesis in mice. Cai K, et al. PLoS One, 2011. PMID 21998670, Free PMC Article

    See all (149) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Molecular Genomic Study of Inhibin Molecule Production through Granulosa Cell Gene Expression in Inhibin-Deficient Mice.
      Title: Molecular Genomic Study of Inhibin Molecule Production through Granulosa Cell Gene Expression in Inhibin-Deficient Mice.
    2. absence of the inhibin alpha-subunit has marginal effects on activins in the epididymis and vas deferens, and regression of these tissues is associated with androgen deficiency.
      Title: Activin over-expression in the testis of mice lacking the inhibin α-subunit gene is associated with androgen deficiency and regression of the male reproductive tract.
    3. These data suggest that activin-follistatin regulation may play a role during the development of Experimental autoimmune epididymo-orchitis.
      Title: Testicular activin and follistatin levels are elevated during the course of experimental autoimmune epididymo-orchitis in mice.
    4. This study tested the hypothesis that inhibins act in an autocrine manner on Leydig cells using a pre-pubertal Leydig cell line, TM3, as a model of immature Leydig cells.
      Title: Endogenous inhibins regulate steroidogenesis in mouse TM3 Leydig cells by altering SMAD2 signalling.
    5. The study is the first to identify an intratesticular role for inhibin/inhibin-alpha subunit, demonstrating that a threshold level of this protein is required for normal testis development and to sustain adult somatic testicular cell function.
      Title: Murine Inhibin α-Subunit Haploinsufficiency Causes Transient Abnormalities in Prepubertal Testis Development Followed by Adult Testicular Decline.
    6. inhibin is a broad regulatory marker in anterior pituitary cells
      Title: Characterization of the mechanism of inhibin α-subunit gene in mouse anterior pituitary cells by RNA interference.
    7. A novel role for GDF9 in causing reproductive defects and suppressing tumor initiation in the Inha(-/-) mouse model.
      Title: GDF9 modulates the reproductive and tumor phenotype of female inha-null mice.
    8. Data indicate that the inhibin-alpha promoter is activated synergistically by Wt1 and Sf1.
      Title: Expression of inhibin-alpha is regulated synergistically by Wilms' tumor gene 1 (Wt1) and steroidogenic factor-1 (Sf1) in sertoli cells.
    9. Inhibin alpha-subunit N terminus interacts with activin type IB receptor to disrupt activin signaling.
      Title: Inhibin α-subunit N terminus interacts with activin type IB receptor to disrupt activin signaling.
    10. relationship between inhibin and Sertoli cell activity
      Title: Action mechanism of inhibin α-subunit on the development of Sertoli cells and first wave of spermatogenesis in mice.
    Submit: New GeneRIF Correction See all GeneRIFs (26)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inhibin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inhibin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in hemoglobin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hemoglobin biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in male gonad development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in male gonad development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of follicle-stimulating hormone secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of follicle-stimulating hormone secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ovarian follicle development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ovarian follicle development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of inhibin A complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of inhibin A complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of inhibin B complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of inhibin B complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of inhibin-betaglycan-ActRII complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of inhibin-betaglycan-ActRII complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in photoreceptor inner segment IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in photoreceptor inner segment ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in photoreceptor outer segment IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in photoreceptor outer segment ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    inhibin alpha chain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001329843.2 → NP_001316772.1  inhibin alpha chain isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC115011

    2. NM_010564.6 → NP_034694.3  inhibin alpha chain isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_034694.3

      Status: VALIDATED

      Source sequence(s)
      AC115011
      Consensus CDS
      CCDS15078.1
      UniProtKB/Swiss-Prot
      Q04997, Q6GTG7
      Related
      ENSMUSP00000040310.5, ENSMUST00000037330.5
      Conserved Domains (1) summary
      cl02510
      Location:263 → 366
      TGF_beta; Transforming growth factor beta like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      75483872..75487010
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011238675.3 → XP_011236977.1  inhibin alpha chain isoform X1

      Conserved Domains (1) summary
      cl40434
      Location:181 → 284
      TGF_beta_SF; transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04997.2 GenPept UniProtKB/Swiss-Prot:Q04997

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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