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    Il11ra2 interleukin 11 receptor subunit alpha 2 [ Mus musculus (house mouse) ]

    Gene ID: 16158, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Il11ra2provided by MGI
    Official Full Name
    interleukin 11 receptor subunit alpha 2provided by MGI
    Primary source
    MGI:MGI:109123
    See related
    Ensembl:ENSMUSG00000078735 AllianceGenome:MGI:109123
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Etl2; Etl-2; Il11ra-ps1
    Summary
    Predicted to enable interleukin-11 binding activity and interleukin-11 receptor activity. Predicted to be involved in several processes, including embryo implantation; interleukin-11-mediated signaling pathway; and positive regulation of cell population proliferation. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; integumental system; and nervous system. Orthologous to human IL11RA (interleukin 11 receptor subunit alpha). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 19.5), adrenal adult (RPKM 18.8) and 28 other tissues See more
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    Genomic context

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    See Il11ra2 in Genome Data Viewer
    Location:
    4 A5; 4 22.73 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (42656001..42665744, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (42655275..42665763, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene C-C motif chemokine ligand 19, pseudogene 2 Neighboring gene C-C motif chemokine ligand 21E Neighboring gene C-C motif chemokine ligand 19, pseudogene 4 Neighboring gene RIKEN cDNA 4930578G10 gene Neighboring gene C-C motif chemokine ligand 27b Neighboring gene predicted gene, 53182 Neighboring gene family with sequence similarity 205 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structural analysis of the gene encoding the murine interleukin-11 receptor alpha-chain and a related locus. Robb L, et al. J Biol Chem, 1996 Jun 7. PMID 8662802
    2. Two differentially expressed interleukin-11 receptor genes in the mouse genome. Bilinski P, et al. Biochem J, 1996 Dec 1. PMID 8973540, Free PMC Article
    3. Identification of a second murine interleukin-11 receptor alpha-chain gene (IL11Ra2) with a restricted pattern of expression. Robb L, et al. Genomics, 1997 Mar 15. PMID 9073505
    4. Enhancer trap integrations in mouse embryonic stem cells give rise to staining patterns in chimaeric embryos with a high frequency and detect endogenous genes. Korn R, et al. Mech Dev, 1992 Nov. PMID 1283314
    5. IL-13R alpha 2 membrane and soluble isoforms differ in humans and mice. Chen W, et al. J Immunol, 2009 Dec 15. PMID 20007572, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables interleukin-11 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables interleukin-11 receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables interleukin-11 receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in developmental process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in embryo implantation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in head development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in interleukin-11-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-11 receptor subunit alpha-2
    Names
    IL-11 receptor subunit alpha-2
    IL-11 receptor subunit beta
    IL-11R subunit alpha-2
    IL-11R subunit beta
    IL-11R-alpha-2
    IL-11R-beta
    IL-11RA2
    IL-11RB
    interleukin 11 receptor, alpha chain 2
    interleukin-11 receptor subunit beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001403831.1 → NP_001390760.1  interleukin-11 receptor subunit alpha-2 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      BX548253
      UniProtKB/Swiss-Prot
      A2RTL4, B1AXR8, O09074, P70225, Q78DW8
      Related
      ENSMUSP00000103641.4, ENSMUST00000108006.4

    2. NM_010550.4 → NP_034680.3  interleukin-11 receptor subunit alpha-2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_034680.3

      Status: VALIDATED

      Source sequence(s)
      BX548253
      Consensus CDS
      CCDS38735.1
      UniProtKB/Swiss-Prot
      A2RTL4, B1AXR8, O09074, P70225, Q78DW8
      UniProtKB/TrEMBL
      Q3UIV4
      Related
      ENSMUSP00000158819.2, ENSMUST00000238770.2
      Conserved Domains (4) summary
      smart00410
      Location:33 → 95
      IG_like; Immunoglobulin like
      cd00063
      Location:218 → 310
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:35 → 98
      Ig; Immunoglobulin domain
      cl21522
      Location:112 → 202
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      42656001..42665744 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163735.1 → XP_036019628.1  interleukin-11 receptor subunit alpha-2 isoform X2

      UniProtKB/TrEMBL
      Q3UIV4
      Conserved Domains (2) summary
      smart00409
      Location:37 → 99
      IG; Immunoglobulin
      cd00063
      Location:222 → 314
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70225.4 GenPept UniProtKB/Swiss-Prot:P70225

    Gene LinkOut

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    Research Materials