Ighg2b immunoglobulin heavy constant gamma 2B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ighg2bprovided by MGI
Official Full Name: immunoglobulin heavy constant gamma 2Bprovided by MGI
Primary source: MGI:MGI:96445
See related: Ensembl:ENSMUSG00000076613 IMGT/GENE-DB:IGHG2B; AllianceGenome:MGI:96445
Gene type: other
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IgG2b; Igh-3; gamma2b
Summary: Enables antigen binding activity. Acts upstream of or within phagocytosis; positive regulation of immune response; and positive regulation of phagocytosis. Located in extracellular space. Part of immunoglobulin complex, circulating. Orthologous to several human genes including IGHG1 (immunoglobulin heavy constant gamma 1 (G1m marker)); IGHG2 (immunoglobulin heavy constant gamma 2 (G2m marker)); and IGHG3 (immunoglobulin heavy constant gamma 3 (G3m marker)). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: 12 F1; 12 62.1 cM

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (113267934..113271553, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (113304314..113307933, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IgD class-switch recombination via germline deletion of the IgH 3' regulatory region.
Title: Elucidation of the enigmatic IgD class-switch recombination via germline deletion of the IgH 3' regulatory region.
a variety of IgG2a- and IgG2b-dependent effector functions are impaired in the absence of Fcgr4 in models of autoimmunity and antibody-dependent cellular cytotoxicity.
Title: FcγRIV deletion reveals its central role for IgG2a and IgG2b activity in vivo.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI326478 (e-PCR)
- UniSTS:180487

AU044919 (e-PCR)
- UniSTS:160264

PMC312773P1 (e-PCR)
- UniSTS:272917

D12Mit41 (e-PCR), detects polymorphism
- UniSTS:141856

D12Mit20 (e-PCR), detects polymorphism
- UniSTS:116787

UniSTS:461920 (e-PCR)
- UniSTS:461920

Igh-6 (e-PCR), detects polymorphism
- UniSTS:461920

Igh (e-PCR), detects polymorphism
- UniSTS:143493

PMC124510P1 (e-PCR)
- UniSTS:270472

Igh-6 (e-PCR), detects polymorphism
- UniSTS:143498

Igh-8 (e-PCR), detects polymorphism
- UniSTS:143499

Igh-C (e-PCR), detects polymorphism
- UniSTS:143500

D12Mit41 (e-PCR), detects polymorphism
- UniSTS:126863

D12Mit41.1 (e-PCR), detects polymorphism
- UniSTS:126864

PMC305257P2 (e-PCR)
- UniSTS:272540

Fusip1 (e-PCR), detects polymorphism
- UniSTS:525486

D12Mit8 (e-PCR), detects polymorphism
- UniSTS:126899

M-04725 (e-PCR)
- UniSTS:186305

NoName (e-PCR)
- UniSTS:224213

AI324046 (e-PCR)
- UniSTS:165853

Other Names

immunoglobulin heavy chain 3 (serum IgG2b)

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Fc-gamma receptor I complex binding	ISO Inferred from Sequence Orthology more info
enables antigen binding	IBA Inferred from Biological aspect of Ancestor more info
enables antigen binding	IDA Inferred from Direct Assay more info	PubMed
enables immunoglobulin receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in antibacterial humoral response	IBA Inferred from Biological aspect of Ancestor more info
involved_in complement activation, classical pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within complement activation, classical pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within humoral immune response mediated by circulating immunoglobulin	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within immunoglobulin mediated immune response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within phagocytosis, engulfment	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within phagocytosis, recognition	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of immune response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of phagocytosis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of type I hypersensitivity	IDA Inferred from Direct Assay more info
acts_upstream_of_or_within positive regulation of type IIa hypersensitivity	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of IgG immunoglobulin complex	ISO Inferred from Sequence Orthology more info
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of immunoglobulin complex, circulating	IBA Inferred from Biological aspect of Ancestor more info
part_of immunoglobulin complex, circulating	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.