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    TCEAL6 transcription elongation factor A like 6 [ Homo sapiens (human) ]

    Gene ID: 158931, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TCEAL6provided by HGNC
    Official Full Name
    transcription elongation factor A like 6provided by HGNC
    Primary source
    HGNC:HGNC:24553
    See related
    AllianceGenome:HGNC:24553
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    WEX2; Tceal3
    Summary
    Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Annotation information
    Annotation category: suggests misassembly
    Expression
    Biased expression in brain (RPKM 18.6), testis (RPKM 12.2) and 4 other tissues See more
    Orthologs
    all
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    Genomic context

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    See TCEAL6 in Genome Data Viewer
    Location:
    Xq22.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (102138502..102142481, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (100583085..100587065, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (101393474..101397453, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene MT-ND6 pseudogene 13 Neighboring gene transcription elongation factor A like 2 Neighboring gene uncharacterized LOC105373299 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29813 Neighboring gene brain expressed X-linked 5 Neighboring gene t-complex 11 family, X-linked 3, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. hsa_circ_0101119 facilitates the progression of cervical cancer via an interaction with EIF4A3 to inhibit TCEAL6 expression. Sui X, et al. Mol Med Rep, 2021 Sep. PMID 34278492, Free PMC Article
    2. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. Winter EE, et al. BMC Evol Biol, 2005 Oct 12. PMID 16221301, Free PMC Article
    3. A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere shortening. Shamay M, et al. J Virol, 2012 May. PMID 22379092, Free PMC Article
    4. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. hsa_circ_0101119 facilitates the progression of cervical cancer via an interaction with EIF4A3 to inhibit TCEAL6 expression.
      Title: hsa_circ_0101119 facilitates the progression of cervical cancer via an interaction with EIF4A3 to inhibit TCEAL6 expression.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transcription elongation factor A protein-like 6
    Names
    TCEA-like protein 6
    transcription elongation factor A (SII)-like 3
    transcription elongation factor A (SII)-like 6
    transcription elongation factor S-II protein-like 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006938.3 → NP_001006939.2  transcription elongation factor A protein-like 6 isoform 2

      See identical proteins and their annotated locations for NP_001006939.2

      Status: VALIDATED

      Source sequence(s)
      Z70719
      Conserved Domains (2) summary
      pfam04538
      Location:72 → 173
      BEX; Brain expressed X-linked like family
      pfam15724
      Location:27 → 94
      TMEM119; TMEM119 family

    2. NM_001367790.1 → NP_001354719.1  transcription elongation factor A protein-like 6 isoform 1

      Status: VALIDATED

      Source sequence(s)
      Z70719
      UniProtKB/Swiss-Prot
      Q5H9J8, Q6IPX3

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      102138502..102142481 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791816.1 Reference GRCh38.p14 PATCHES

      Range
      33591..37571 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      100583085..100587065 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IPX3.1 GenPept UniProtKB/Swiss-Prot:Q6IPX3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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