Foxj1 forkhead box J1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Foxj1provided by MGI
Official Full Name: forkhead box J1provided by MGI
Primary source: MGI:MGI:1347474
See related: Ensembl:ENSMUSG00000034227 AllianceGenome:MGI:1347474
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hfh4; HFH-4; FKHL-13
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; negative regulation of lymphocyte activation; and regulation of DNA-templated transcription. Acts upstream of or within several processes, including cell maturation; determination of left/right symmetry; and establishment of apical/basal cell polarity. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; nose; and respiratory system. Used to study Kartagener syndrome; congenital heart disease; and primary ciliary dyskinesia. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 43. Orthologous to human FOXJ1 (forkhead box J1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in ovary adult (RPKM 53.6), lung adult (RPKM 41.4) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 81.16 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (116221530..116226331, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (116330704..116335499, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Heterozygous FOXJ1 Mutations Cause Incomplete Ependymal Cell Differentiation and Communicating Hydrocephalus.
Title: Heterozygous FOXJ1 Mutations Cause Incomplete Ependymal Cell Differentiation and Communicating Hydrocephalus.
LRRC6 regulates biogenesis of motile cilia by aiding FOXJ1 translocation into the nucleus.
Title: LRRC6 regulates biogenesis of motile cilia by aiding FOXJ1 translocation into the nucleus.
The Association between the Decreased Expression Levels of FOXJ1 and the Activation of the NF-kB Pathway in Interstitial Lung Disease of MR L/Lpr Mice.
Title: The Association between the Decreased Expression Levels of FOXJ1 and the Activation of the NF-kB Pathway in Interstitial Lung Disease of MR L/Lpr Mice.
The highly conserved FOXJ1 target CFAP161 is dispensable for motile ciliary function in mouse and Xenopus.
Title: The highly conserved FOXJ1 target CFAP161 is dispensable for motile ciliary function in mouse and Xenopus.
RNA demethylation by FTO stabilizes the FOXJ1 mRNA for proper motile ciliogenesis.
Title: RNA demethylation by FTO stabilizes the FOXJ1 mRNA for proper motile ciliogenesis.
The FOXJ1 target Cfap206 is required for sperm motility, mucociliary clearance of the airways and brain development.
Title: The FOXJ1 target Cfap206 is required for sperm motility, mucociliary clearance of the airways and brain development.
A subpopulation of nonmyelinating Schwann cells in the peripheral nervous system, were identified by the expression of Foxj1.
Title: A Subpopulation of Foxj1-Expressing, Nonmyelinating Schwann Cells of the Peripheral Nervous System Contribute to Schwann Cell Remyelination in the Central Nervous System.
uncovers unexpected developmental functions of FoxJ1 in cell fate determination of subsets of neural cells and suggests that FoxJ1 is critical for maintaining the stem cell potential of ependymal cells into adulthood
Title: FoxJ1 regulates spinal cord development and is required for the maintenance of spinal cord stem cell potential.
Non stem- and progenitor-like responses of Foxj1+ ependymal cells to injury and stroke remain to be defined and investigated.
Title: Foxj1 expressing ependymal cells do not contribute new cells to sites of injury or stroke in the mouse forebrain.
Our findings provide clues regarding the role of FOXJ1 as a tumor inducer in bladder cancer and an enhancer in glycolysis. Targeting FOXJ1 could be a potential therapeutic strategy in bladder cancer.
Title: FOXJ1 promotes bladder cancer cell growth and regulates Warburg effect.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (4)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Foxj1 (e-PCR), detects polymorphism
- UniSTS:259328

Foxj1 (e-PCR), detects polymorphism
- UniSTS:547227

Foxj1 (e-PCR), detects polymorphism
- UniSTS:525751

Foxj1 (e-PCR), detects polymorphism
- UniSTS:547511

NoName (e-PCR)
- UniSTS:236782

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in activation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in axoneme assembly	ISO Inferred from Sequence Orthology more info
involved_in axoneme assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in brain development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cell maturation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in central tolerance induction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ciliary basal body organization	ISO Inferred from Sequence Orthology more info
involved_in ciliary basal body organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of left/right symmetry	ISO Inferred from Sequence Orthology more info
involved_in determination of left/right symmetry	ISS Inferred from Sequence or Structural Similarity more info
involved_in epithelium development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within establishment of apical/basal cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glomerular parietal epithelial cell development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in humoral immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within left/right pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leukocyte migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lung epithelium development	IEA Inferred from Electronic Annotation more info
involved_in metanephric part of ureteric bud development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within motile cilium assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in motile cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of B cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of NF-kappaB transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of T cell differentiation in thymus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of germinal center formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of humoral immune response mediated by circulating immunoglobulin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of central B cell tolerance induction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of lung ciliated cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of lung ciliated cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein localization	ISO Inferred from Sequence Orthology more info
involved_in protein localization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of epithelial cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: forkhead box protein J1

Names: HNF-3/forkhead homolog 4; forkhead-related protein FKHL13; hepatocyte nuclear factor 3 forkhead homolog 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001431559.1 → NP_001418488.1 forkhead box protein J1

Status: VALIDATED

Source sequence(s)

AL645861

UniProtKB/Swiss-Prot

Q3US42, Q61660
NM_008240.4 → NP_032266.3 forkhead box protein J1

See identical proteins and their annotated locations for NP_032266.3

Status: VALIDATED

Source sequence(s)

AL645861

Consensus CDS

CCDS25665.1

UniProtKB/Swiss-Prot

Q3US42, Q61660

UniProtKB/TrEMBL

Q640Q8

Related

ENSMUSP00000038351.7, ENSMUST00000036215.8

Conserved Domains (1) summary

pfam00250
Location:121 → 205

Forkhead; Forkhead domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

116221530..116226331 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006532269.4 → XP_006532332.1 forkhead box protein J1 isoform X1

Conserved Domains (1) summary

pfam00250
Location:121 → 205

Forkhead; Forkhead domain