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    S spike glycoprotein [ SARS coronavirus Tor2 ]

    Gene ID: 1489668, updated on 3-Nov-2024

    Summary

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    Gene symbol
    S
    Gene description
    spike glycoprotein
    Locus tag
    sars2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    SARS coronavirus Tor2 (isolate: Tor2, nat-host: Homo sapiens; patient #2 with severe acute respiratory syndrome (SARS))
    Lineage
    Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; Betacoronavirus; Sarbecovirus
    Also known as
    E2
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    Genomic context

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    Sequence:
    NC_004718.3 (21492..25259)

    NC_004718.3Genomic Context describing neighboring genes Neighboring gene ORF1a polyprotein;ORF1ab polyprotein Neighboring gene ORF3a protein Neighboring gene ORF3b protein Neighboring gene small envelope protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_004718.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Modulation of the immune response to the severe acute respiratory syndrome spike glycoprotein by gene-based and inactivated virus immunization. Kong WP, et al. J Virol, 2005 Nov. PMID 16254327, Free PMC Article
    2. Pinpointing the potential hits for hindering interaction of SARS-CoV-2 S-protein with ACE2 from the pool of antiviral phytochemicals utilizing molecular docking and molecular dynamics (MD) simulations. Patel CN, et al. J Mol Graph Model, 2021 Jun. PMID 33647752, Free PMC Article
    3. Characterization of a highly conserved domain within the severe acute respiratory syndrome coronavirus spike protein S2 domain with characteristics of a viral fusion peptide. Madu IG, et al. J Virol, 2009 Aug. PMID 19439480, Free PMC Article
    4. In silico investigation of critical binding pattern in SARS-CoV-2 spike protein with angiotensin-converting enzyme 2. Jafary F, et al. Sci Rep, 2021 Mar 25. PMID 33767306, Free PMC Article
    5. Computational epitope map of SARS-CoV-2 spike protein. Sikora M, et al. PLoS Comput Biol, 2021 Apr. PMID 33793546, Free PMC Article

    See all (202) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Allosteric pathways of SARS and SARS-CoV-2 spike protein identified by neural relational inference.
      Title: Allosteric pathways of SARS and SARS-CoV-2 spike protein identified by neural relational inference.
    2. Mapping immunological and host receptor binding determinants of SARS-CoV spike protein utilizing the Qubevirus platform.
      Title: Mapping immunological and host receptor binding determinants of SARS-CoV spike protein utilizing the Qubevirus platform.
    3. Effects of SARS-CoV-2 Omicron BA.1 Spike Mutations on T-Cell Epitopes in Mice.
      Title: Effects of SARS-CoV-2 Omicron BA.1 Spike Mutations on T-Cell Epitopes in Mice.
    4. Spike substitution T813S increases Sarbecovirus fusogenicity by enhancing the usage of TMPRSS2.
      Title: Spike substitution T813S increases Sarbecovirus fusogenicity by enhancing the usage of TMPRSS2.
    5. Elucidating the role of N440K mutation in SARS-CoV-2 spike - ACE-2 binding affinity and COVID-19 severity by virtual screening, molecular docking and dynamics approach.
      Title: Elucidating the role of N440K mutation in SARS-CoV-2 spike - ACE-2 binding affinity and COVID-19 severity by virtual screening, molecular docking and dynamics approach.
    6. The SARS-CoV-2 spike protein binds and modulates estrogen receptors.
      Title: The SARS-CoV-2 spike protein binds and modulates estrogen receptors.
    7. A Vaccine of SARS-CoV-2 S Protein RBD Induces Protective Immunity.
      Title: A Vaccine of SARS-CoV-2 S Protein RBD Induces Protective Immunity.
    8. SARS-CoV-2 Spike protein suppresses CTL-mediated killing by inhibiting immune synapse assembly.
      Title: SARS-CoV-2 Spike protein suppresses CTL-mediated killing by inhibiting immune synapse assembly.
    9. Energetics of Spike Protein Opening of SARS-CoV-1 and SARS-CoV-2 and Its Variants of Concern: Implications in Host Receptor Scanning and Transmission.
      Title: Energetics of Spike Protein Opening of SARS-CoV-1 and SARS-CoV-2 and Its Variants of Concern: Implications in Host Receptor Scanning and Transmission.
    10. SARS-CoV-2 spike protein aggregation is triggered by bacterial lipopolysaccharide.
      Title: SARS-CoV-2 spike protein aggregation is triggered by bacterial lipopolysaccharide.
    Submit: New GeneRIF Correction See all GeneRIFs (124)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

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    Preferred Names
    spike glycoprotein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004718.3 Reference assembly

      Range
      21492..25259
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_009825051.1 spike glycoprotein [SARS coronavirus Tor2]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P59594, Q6QU82, Q7T696, Q7TA19, Q7TFA2, Q7TFB1, Q80BV6
      UniProtKB/TrEMBL
      A0A3G5BJ39, A7J8L4, D2E1D2, D2E1E7, D3KDQ3, Q202E9, Q309G9, Q3S2D2, Q6JH38, Q6RCW5, Q6RCX6, Q6RCZ8, Q6RD09, Q6RD42, Q6RD53, Q6V585, Q6VA89, Q6WGP3
      Conserved Domains (4) summary
      cd21481
      Location:306 → 527
      SARS-CoV_Spike_S1_RBD; receptor-binding domain of the S1 subunit of severe acute respiratory syndrome-related coronavirus Spike (S) protein
      cd21624
      Location:17 → 291
      SARS-CoV-like_Spike_S1_NTD; N-terminal domain of the S1 subunit of the Spike (S) protein from Severe acute respiratory syndrome coronavirus and related betacoronaviruses in the B lineage
      pfam19214
      Location:1215 → 1255
      CoV_S2_C; Coronavirus spike glycoprotein S2, intravirion
      cd22378
      Location:529 → 1190
      SARS-CoV-like_Spike_SD1-2_S1-S2_S2; SD-1 and SD-2 subdomains, the S1/S2 cleavage region, and the S2 fusion subunit of the spike (S) glycoprotein from SARS-CoV-2 (COVID-19) and related betacoronaviruses in the B lineage
    Nucleotide Protein
    Heading Accession and Version

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