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    E7 transforming protein E7 [ Human papillomavirus 16 ]

    Gene ID: 1489079, updated on 4-Aug-2024

    Summary

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    Gene symbol
    E7
    Gene description
    transforming protein E7
    Locus tag
    HpV16gp2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Human papillomavirus 16
    Lineage
    Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Alphapapillomavirus; Alphapapillomavirus 9
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    Genomic context

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    Sequence:
    NC_001526.4 (7604..7900)

    NC_001526.4Genomic Context describing neighboring genes Neighboring gene minor capsid protein L2 Neighboring gene major capsid protein L1 Neighboring gene protein E6*;transforming protein E6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001526.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Significant growth inhibition by a bispecific affibody targeting oncoprotein E7 in both HPV16 and 18 positive cervical cancer in vitro and in vivo. Tan X, et al. Eur J Pharm Sci, 2022 May 1. PMID 35245683
    2. Sustained expression of HPV16 E7 oncoprotein promotes p-AKT(Ser473)/p-Src(Tyr527) signaling to drive precancerous lesions to invasive cervical cancer. Lin Z, et al. Carcinogenesis, 2022 Jun 4. PMID 35134836
    3. Modeling and Molecular Dynamics of the 3D Structure of the HPV16 E7 Protein and Its Variants. Bello-Rios C, et al. Int J Mol Sci, 2021 Jan 30. PMID 33573298, Free PMC Article
    4. Human papillomavirus 16 promotes microhomology-mediated end-joining. Leeman JE, et al. Proc Natl Acad Sci U S A, 2019 Oct 22. PMID 31591214, Free PMC Article
    5. Influence of Human Papillomavirus E7 Oncoprotein on Maturation and Function of Plasmacytoid Dendritic Cells In Vitro. Han R, et al. Virol Sin, 2018 Dec. PMID 30569289, Free PMC Article

    See all (227) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Exploring the Role of E6 and E7 Oncoproteins in Cervical Oncogenesis through MBD2/3-NuRD Complex Chromatin Remodeling.
      Title: Exploring the Role of E6 and E7 Oncoproteins in Cervical Oncogenesis through MBD2/3-NuRD Complex Chromatin Remodeling.
    2. The difference of transcriptome of HPV-infected patients contributes more to the occurrence of cervical cancer than the mutations of E6 and E7 genes in HPV16.
      Title: The difference of transcriptome of HPV-infected patients contributes more to the occurrence of cervical cancer than the mutations of E6 and E7 genes in HPV16.
    3. MAL expression downregulation through suppressive H3K27me3 marks at the promoter in HPV16-related cervical cancers is prognostically relevant and manifested by the interplay of novel MAL antisense long noncoding RNA AC103563.8, E7 oncoprotein and EZH2.
      Title: MAL expression downregulation through suppressive H3K27me3 marks at the promoter in HPV16-related cervical cancers is prognostically relevant and manifested by the interplay of novel MAL antisense long noncoding RNA AC103563.8, E7 oncoprotein and EZH2.
    4. The membrane-associated ubiquitin ligase MARCHF8 stabilizes the human papillomavirus oncoprotein E7 by degrading CUL1 and UBE2L3 in head and neck cancer.
      Title: The membrane-associated ubiquitin ligase MARCHF8 stabilizes the human papillomavirus oncoprotein E7 by degrading CUL1 and UBE2L3 in head and neck cancer.
    5. HPV16 E7 protein antagonizes TNF-alpha-induced apoptosis of cervical cancer cells via Daxx/JNK pathway.
      Title: HPV16 E7 protein antagonizes TNF-α-induced apoptosis of cervical cancer cells via Daxx/JNK pathway.
    6. Genetic variation of E6 and E7 genes of human papillomavirus type 16 from central China.
      Title: Genetic variation of E6 and E7 genes of human papillomavirus type 16 from central China.
    7. Evidence for direct interaction between the oncogenic proteins E6 and E7 of high-risk human papillomavirus (HPV).
      Title: Evidence for direct interaction between the oncogenic proteins E6 and E7 of high-risk human papillomavirus (HPV).
    8. Genetic Variability in the E6/E7 Region of Human Papillomavirus 16 in Women from Ecuador.
      Title: Genetic Variability in the E6/E7 Region of Human Papillomavirus 16 in Women from Ecuador.
    9. Chlamydia trachomatis infection co-operatively enhances HPV E6-E7 oncogenes mediated tumorigenesis and immunosuppression.
      Title: Chlamydia trachomatis infection co-operatively enhances HPV E6-E7 oncogenes mediated tumorigenesis and immunosuppression.
    10. Transmissible Gastroenteritis Virus Nucleocapsid Protein Interacts with Na[+]/H[+] Exchanger 3 To Reduce Na[+]/H[+] Exchanger Activity and Promote Piglet Diarrhea.
      Title: Transmissible Gastroenteritis Virus Nucleocapsid Protein Interacts with Na(+)/H(+) Exchanger 3 To Reduce Na(+)/H(+) Exchanger Activity and Promote Piglet Diarrhea.
    Submit: New GeneRIF Correction See all GeneRIFs (219)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    General protein information

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    Preferred Names
    transforming protein E7
    NP_041326.1
    • E7. Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle.

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001526.4 Reference assembly

      Range
      7604..7900
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_041326.1 transforming protein E7 [Human papillomavirus 16]

      See identical proteins and their annotated locations for NP_041326.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P03129
      UniProtKB/TrEMBL
      A0A0A7DNA1, A0A0H4CQU3, A0A160CDS1, A0A160CE21, A0A161H9K6, A0A1U8QXA6, A0A2P0VGD6, A0A2P0VGD7, A0A2P0VGZ1, A0A2P0VHG2, A0A2P0VHG5, A0A2P0VHY0, A0A2P0VHY3, A0A2P0VIV5, A0A2P0VJU6, A0A2P0VKC6, A0A2P1HJS5, A0A2P1HU85, A0A2P1HYV4, A0A2P1I2C5, A0A2P1I589, A0A2P1IHA0, A0A2P1IJ29, A0A2P1ILF9, A0A2Z5DHM3, A0A384LCP1, A0A384LMA3, A0A384LNE6, A0A7L9VWD9, A0MPS5, C0KXQ5, J3XCL6, O11650, O12337, Q547B8, Q778G4, Q778G6, Q778G8, Q778G9, Q778H1, Q778H2, Q778H5, Q778H7, Q778H9, Q778I0, Q778I1, Q778I3, Q778I5, Q77AI1, Q77GV7, Q8QRD2, S6BHC2
      Conserved Domains (1) summary
      pfam00527
      Location:3 → 94
      E7; E7 protein, Early protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P03129.1

    Gene LinkOut

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