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    Nmur1 neuromedin U receptor 1 [ Mus musculus (house mouse) ]

    Gene ID: 14767, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Nmur1provided by MGI
    Official Full Name
    neuromedin U receptor 1provided by MGI
    Primary source
    MGI:MGI:1341898
    See related
    Ensembl:ENSMUSG00000026237 AllianceGenome:MGI:1341898
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FM-3; Gpr66; NMU1R; NmU-R; NMU-R1
    Summary
    Enables neuropeptide receptor activity. Acts upstream of or within neuropeptide signaling pathway. Is active in cilium. Is expressed in brain; esophagus; and male reproductive gland or organ. Orthologous to human NMUR1 (neuromedin U receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 6.3), small intestine adult (RPKM 3.0) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nmur1 in Genome Data Viewer
    Location:
    1 C5; 1 43.94 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (86313964..86317083, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (86386242..86389361, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene nucleolin Neighboring gene RIKEN cDNA C130036L24 gene Neighboring gene STARR-positive B cell enhancer ABC_E406 Neighboring gene small nucleolar RNA, C/D box 82 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:88320435-88320760 Neighboring gene STARR-positive B cell enhancer ABC_E1553 Neighboring gene testis expressed 44 Neighboring gene predicted gene, 32700 Neighboring gene STARR-positive B cell enhancer ABC_E3286

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Activation of neuromedin U type 1 receptor inhibits L-type Ca2+ channel currents via phosphatidylinositol 3-kinase-dependent protein kinase C epsilon pathway in mouse hippocampal neurons. Zhang Y, et al. Cell Signal, 2010 Nov. PMID 20599609
    2. Neuromedin U type 1 receptor stimulation of A-type K+ current requires the βγ subunits of Go protein, protein kinase A, and extracellular signal-regulated kinase 1/2 (ERK1/2) in sensory neurons. Zhang Y, et al. J Biol Chem, 2012 May 25. PMID 22493291, Free PMC Article
    3. Cloning and characterization of a human and murine T-cell orphan G-protein-coupled receptor similar to the growth hormone secretagogue and neurotensin receptors. Tan CP, et al. Genomics, 1998 Sep 1. PMID 9782091
    4. Mice genetically deficient in neuromedin U receptor 2, but not neuromedin U receptor 1, have impaired nociceptive responses. Torres R, et al. Pain, 2007 Aug. PMID 17379411
    5. Nmur1-/- mice are not protected from cutaneous inflammation. Abbondanzo SJ, et al. Biochem Biophys Res Commun, 2009 Jan 23. PMID 19070594

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Neuromedin U regulates the anti-tumor activity of CD8[+] T cells and glycolysis of tumor cells in the tumor microenvironment of pancreatic ductal adenocarcinoma in an NMUR1-dependent manner.
      Title: Neuromedin U regulates the anti-tumor activity of CD8(+) T cells and glycolysis of tumor cells in the tumor microenvironment of pancreatic ductal adenocarcinoma in an NMUR1-dependent manner.
    2. Neuromedin U programs eosinophils to promote mucosal immunity of the small intestine.
      Title: Neuromedin U programs eosinophils to promote mucosal immunity of the small intestine.
    3. Postnatal ontogeny of Neuromedin S and its receptors NMUR1 and NMUR2 expression in mouse testis.
      Title: Postnatal ontogeny of Neuromedin S and its receptors NMUR1 and NMUR2 expression in mouse testis.
    4. Neuromedin U (NMU) regulates osteoblast differentiation and activity.
      Title: Neuromedin U (NMU) regulates osteoblast differentiation and activity.
    5. These results suggested that NMU can act directly on beta cells through NMUR1 in an autocrine or paracrine fashion to suppress insulin secretion. Collectively, our results highlight the crucial role of NMU in suppressing pancreatic insulin secretion, and may improve our understanding of glucose homeostasis.
      Title: Neuromedin U suppresses glucose-stimulated insulin secretion in pancreatic β cells.
    6. Data show that deficiency of neuromedin receptors NMUR1 and NMUR2 had no impact on arthritis severity.
      Title: The neuropeptide neuromedin U promotes autoantibody-mediated arthritis.
    7. results suggested that NMU increases I(A) via activation of NMUR1 that couples sequentially to the downstream activities of Gbetagamma of the G(o) protein, PKA, and ERK
      Title: Neuromedin U type 1 receptor stimulation of A-type K+ current requires the βγ subunits of Go protein, protein kinase A, and extracellular signal-regulated kinase 1/2 (ERK1/2) in sensory neurons.
    8. neuromedin-U receptor 1 inhibits L-type HVGCC via activation of NMUR1 and downstream G(betagamma), PI3K, and a novel PKC epsilon signaling pathway.
      Title: Activation of neuromedin U type 1 receptor inhibits L-type Ca2+ channel currents via phosphatidylinositol 3-kinase-dependent protein kinase C epsilon pathway in mouse hippocampal neurons.
    9. A study evaluating smooth muscle contraction in NMU1 receptor knockout mouse was used to determine which receptor subtype mediates the contractile responses generated by neuromedin in the mouse.[NMU1 receptor]
      Title: Species-dependent smooth muscle contraction to Neuromedin U and determination of the receptor subtypes mediating contraction using NMU1 receptor knockout mice.
    10. These data argues against a major role for Nmur1 in mediating the reported inflammatory functions of NmU.
      Title: Nmur1-/- mice are not protected from cutaneous inflammation.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables neuromedin U binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neuromedin U binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables neuromedin U receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neuromedin U receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables neuropeptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neuropeptide receptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chloride transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chloride transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neuropeptide signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neuromedin-U receptor 1
    Names
    G protein-coupled receptor 66

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001319227.1 → NP_001306156.1  neuromedin-U receptor 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC102609, BC120822
      Consensus CDS
      CCDS15119.2
      UniProtKB/Swiss-Prot
      G5E871, O55040, Q0VB23
      UniProtKB/TrEMBL
      A0A1C7ZMY0
      Related
      ENSMUSP00000148767.2, ENSMUST00000212058.2
      Conserved Domains (2) summary
      pfam00001
      Location:77 → 357
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:64 → 195
      7tm_4; Olfactory receptor

    2. NM_010341.1 → NP_034471.1  neuromedin-U receptor 1 isoform 2

      See identical proteins and their annotated locations for NP_034471.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the UTRs and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AF044602
      Consensus CDS
      CCDS83570.1
      UniProtKB/TrEMBL
      A0A1C7ZMY0
      Related
      ENSMUSP00000027440.6, ENSMUST00000027440.7
      Conserved Domains (2) summary
      pfam00001
      Location:54 → 334
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:41 → 172
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      86313964..86317083 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O55040.2 GenPept UniProtKB/Swiss-Prot:O55040

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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