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    Gng4 guanine nucleotide binding protein (G protein), gamma 4 [ Mus musculus (house mouse) ]

    Gene ID: 14706, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Gng4provided by MGI
    Official Full Name
    guanine nucleotide binding protein (G protein), gamma 4provided by MGI
    Primary source
    MGI:MGI:102703
    See related
    Ensembl:ENSMUSG00000021303 AllianceGenome:MGI:102703
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hg3c
    Summary
    This gene encodes the gamma subunit of the heterotrimeric G-proteins that are comprised of alpha, beta and gamma subunits. Upon activation by G protein-coupled receptors, the beta-gamma heterodimer dissociates from the alpha subunit to activate downstream signaling events. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
    Expression
    Biased expression in frontal lobe adult (RPKM 69.2), CNS E18 (RPKM 22.4) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gng4 in Genome Data Viewer
    Location:
    13 A1; 13 5.29 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (13958644..14002480)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (13784059..13827895)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene nidogen 1 Neighboring gene STARR-positive B cell enhancer ABC_E11531 Neighboring gene STARR-seq mESC enhancer starr_33691 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:13656913-13657141 Neighboring gene STARR-positive B cell enhancer ABC_E1868 Neighboring gene predicted gene, 30836 Neighboring gene lysosomal trafficking regulator Neighboring gene STARR-seq mESC enhancer starr_33693 Neighboring gene STARR-seq mESC enhancer starr_33694 Neighboring gene STARR-seq mESC enhancer starr_33698 Neighboring gene STARR-seq mESC enhancer starr_33699 Neighboring gene STARR-seq mESC enhancer starr_33701 Neighboring gene STARR-seq mESC enhancer starr_33703 Neighboring gene predicted gene 7441 Neighboring gene STARR-seq mESC enhancer starr_33704 Neighboring gene STARR-positive B cell enhancer ABC_E5368 Neighboring gene heterogeneous nuclear ribonucleoprotein F pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A brain-specific G protein gamma subunit. Kalyanaraman S, et al. Biochem Biophys Res Commun, 1995 Nov 2. PMID 7488078
    2. A disulphide-linked heterodimer of TWIK-1 and TREK-1 mediates passive conductance in astrocytes. Hwang EM, et al. Nat Commun, 2014. PMID 24496152
    3. Selectivity in signal transduction determined by gamma subunits of heterotrimeric G proteins. Kleuss C, et al. Science, 1993 Feb 5. PMID 8094261
    4. Structure and chromosomal localization of mouse G protein subunit gamma 4 gene. Kalyanaraman S, et al. Genomics, 1998 Apr 1. PMID 9570961
    5. G protein diversity is increased by associations with a variety of gamma subunits. Gautam N, et al. Proc Natl Acad Sci U S A, 1990 Oct. PMID 2122451, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G-protein beta-subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G-protein beta-subunit binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    involved_in negative regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of heterotrimeric G-protein complex ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
    Names
    heterotrimeric guanine nucleotide-binding protein 3c

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302997.1 → NP_001289926.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 precursor

      See identical proteins and their annotated locations for NP_001289926.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC171200
      Consensus CDS
      CCDS36598.1
      UniProtKB/Swiss-Prot
      P50153
      UniProtKB/TrEMBL
      Q3UFJ8
      Conserved Domains (1) summary
      smart00224
      Location:13 → 75
      GGL; G protein gamma subunit-like motifs

    2. NM_010317.3 → NP_034447.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 precursor

      See identical proteins and their annotated locations for NP_034447.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AC171200, BC016506
      Consensus CDS
      CCDS36598.1
      UniProtKB/Swiss-Prot
      P50153
      UniProtKB/TrEMBL
      Q3UFJ8
      Related
      ENSMUSP00000021734.8, ENSMUST00000021734.9
      Conserved Domains (1) summary
      smart00224
      Location:13 → 75
      GGL; G protein gamma subunit-like motifs

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      13958644..14002480
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50153.1 GenPept UniProtKB/Swiss-Prot:P50153

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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