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    Gdap2 ganglioside-induced differentiation-associated-protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 14547, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Gdap2provided by MGI
    Official Full Name
    ganglioside-induced differentiation-associated-protein 2provided by MGI
    Primary source
    MGI:MGI:1338001
    See related
    Ensembl:ENSMUSG00000027865 AllianceGenome:MGI:1338001
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D3Ertd801e
    Summary
    Acts upstream of or within response to retinoic acid. Is expressed in several structures, including brain; ganglia; liver; orbito-sphenoid; and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 27. Orthologous to human GDAP2 (ganglioside induced differentiation associated protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 7.1), testis adult (RPKM 6.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gdap2 in Genome Data Viewer
    Location:
    3 F2.2; 3 43.49 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (100069843..100117909)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (100162381..100206989)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene sperm associated antigen 17 Neighboring gene ribosomal protein L36, pseudogene 7 Neighboring gene STARR-seq mESC enhancer starr_08490 Neighboring gene STARR-seq mESC enhancer starr_08491 Neighboring gene STARR-positive B cell enhancer ABC_E6088 Neighboring gene WD repeat domain 3 Neighboring gene STARR-seq mESC enhancer starr_08494 Neighboring gene predicted gene, 25802 Neighboring gene STARR-seq mESC enhancer starr_08495 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Isolation of 10 differentially expressed cDNAs in differentiated Neuro2a cells induced through controlled expression of the GD3 synthase gene. Liu H, et al. J Neurochem, 1999 May. PMID 10217254
    2. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    3. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to retinoic acid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ganglioside-induced differentiation-associated protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410111.1 → NP_001397040.1  ganglioside-induced differentiation-associated protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC102209, AL606742
      UniProtKB/Swiss-Prot
      O88742, Q8C468, Q9DBL2

    2. NM_001410112.1 → NP_001397041.1  ganglioside-induced differentiation-associated protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC102209, AL606742

    3. NM_010269.4 → NP_034399.1  ganglioside-induced differentiation-associated protein 2 isoform 1

      See identical proteins and their annotated locations for NP_034399.1

      Status: VALIDATED

      Source sequence(s)
      AC102209, AL606742
      Consensus CDS
      CCDS17675.1
      UniProtKB/Swiss-Prot
      O88742, Q8C468, Q9DBL2
      Related
      ENSMUSP00000029459.4, ENSMUST00000029459.10
      Conserved Domains (2) summary
      cd02905
      Location:54 → 193
      Macro_GDAP2_like; Macro domain, GDAP2_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...
      pfam13716
      Location:350 → 481
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    RNA

    1. NR_104341.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC102209, AL606742

    2. NR_176946.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC102209, AL606742

    3. NR_176948.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC102209, AL606742

    4. NR_176949.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC102209, AL606742

    5. NR_176950.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC102209, AL606742

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      100069843..100117909
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DBL2.1 GenPept UniProtKB/Swiss-Prot:Q9DBL2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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