U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Fau FAU ubiquitin like and ribosomal protein S30 fusion [ Mus musculus (house mouse) ]

    Gene ID: 14109, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Fauprovided by MGI
    Official Full Name
    FAU ubiquitin like and ribosomal protein S30 fusionprovided by MGI
    Primary source
    MGI:MGI:102547
    See related
    Ensembl:ENSMUSG00000038274 AllianceGenome:MGI:102547
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MNSFB; MNSFbeta
    Summary
    Predicted to enable protein tag activity and ubiquitin protein ligase binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in several processes, including defense response to other organism; protein ubiquitination; and ribosomal small subunit assembly. Predicted to be located in cytosolic ribosome and extracellular space. Predicted to be part of cytosolic small ribosomal subunit. Predicted to be active in cytoplasm and nucleus. Is expressed in decidua; embryo; and uterus. Orthologous to human FAU (FAU ubiquitin like and ribosomal protein S30 fusion). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in spleen adult (RPKM 573.2), ovary adult (RPKM 507.1) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Fau in Genome Data Viewer
    Location:
    19 A; 19 4.34 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6107977..6109554)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6057947..6059524)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene synovial apoptosis inhibitor 1, synoviolin Neighboring gene microRNA 6988 Neighboring gene mitochondrial ribosomal protein L49 Neighboring gene STARR-seq mESC enhancer starr_45418 Neighboring gene zinc finger, HIT domain containing 2 Neighboring gene transmembrane 7 superfamily member 2 Neighboring gene VPS51 GARP complex subunit

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Investigating the regulatory mechanism of glucose metabolism by ubiquitin-like protein MNSFβ. Kono M, et al. Mol Biol Rep, 2024 Oct 15. PMID 39404900
    2. [Expression of monoclonal nonspecific suppressor factor beta in E. coli, preparation of its antibodies and its tissue orientation in the mouse endometrium]. Huang ZP, et al. Shi Yan Sheng Wu Xue Bao, 2002 Jun. PMID 15344325
    3. Molecular cloning and characterization of a cDNA encoding monoclonal nonspecific suppressor factor. Nakamura M, et al. Proc Natl Acad Sci U S A, 1995 Apr 11. PMID 7724584, Free PMC Article
    4. Noncovalent interaction of MNSFbeta, a ubiquitin-like protein, with histone 2A. Nakamura M, et al. Comp Biochem Physiol B Biochem Mol Biol, 2005 Feb. PMID 15649767
    5. The ubiquitin-like protein MNSFbeta regulates ERK-MAPK cascade. Nakamura M, et al. J Biol Chem, 2006 Jun 23. PMID 16621790

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Investigating the regulatory mechanism of glucose metabolism by ubiquitin-like protein MNSFbeta.
      Title: Investigating the regulatory mechanism of glucose metabolism by ubiquitin-like protein MNSFβ.
    2. MALDI-TOF mass spectrometry fingerprinting revealed that this MNSFbeta adduct consists of an 8.5 kDa MNSFbeta and heat shock protein 60 (HSP60), a mitochondrial protein involved in protein folding.
      Title: Heat shock protein 60 negatively regulates the biological functions of ubiquitin-like protein MNSFβ in macrophages.
    3. the association of MNSFbeta with HSPA8 may promote RANKL-induced osteoclastogenesis.
      Title: Ubiquitin-like protein MNSFβ noncovalently binds to molecular chaperone HSPA8 and regulates osteoclastogenesis.
    4. Collectively, MNSFbeta/FDH complex formation may positively regulate apoptosis in thymocytes.
      Title: Ubiquitin-like protein MNSFβ covalently binds to cytosolic 10-formyltetrahydrofolate dehydrogenase and regulates thymocyte function.
    5. these results demonstrated that a deficiency in MNSFb is associated with pregnancy loss, probably through reduced P53 and/or increased TNFA production at the fetal-maternal interface.
      Title: Deficiency of monoclonal non-specific suppressor factor beta (MNSFB) promotes pregnancy loss in mice.
    6. CD3/CD28-inducible MNSFbeta-Bcl-G complex may be involved in the regulation of T cell function and survival.
      Title: Ubiquitin-like protein MNSFβ negatively regulates T cell function and survival.
    7. MNSFbeta may bind to novel target proteins and negatively regulate TLR-2-mediated signal transduction in macrophages.
      Title: Ubiquitin-like protein MNSFβ regulates TLR-2-mediated signal transduction.
    8. these results demonstrate that MNSFbeta/endophilin II inhibits the signal pathway upstream of IKK activation, but not downstream of TLR2 signaling.
      Title: Ubiquitin-like protein MNSFβ/endophilin II complex regulates Dectin-1-mediated phagocytosis and inflammatory responses in macrophages.
    9. The result suggested that the level of MNSFbeta in interimplantation sites was significantly higher as compared with implantation sites in the mouse uterine on Day 4.5 of pregnancy
      Title: [Expression of monoclonal nonspecific suppressor factor beta in E. coli, preparation of its antibodies and its tissue orientation in the mouse endometrium].
    10. post-translational modification of endophilin II by MNSFbeta might be implicated in phagocytosis by macrophages.
      Title: The ubiquitin-like protein monoclonal nonspecific suppressor factor beta conjugates to endophilin II and regulates phagocytosis.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tag activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in antibacterial humoral response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in innate immune response in mucosa ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in modification-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal small subunit assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytosolic small ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    ubiquitin-like FUBI-ribosomal protein eS30 fusion protein
    Names
    40S ribosomal protein S30
    FAU ubiquitin-like and ribosomal protein S30
    Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived)
    MNSF-beta
    monoclonal non-specific suppressor factor beta
    monoclonal nonspecific suppressor factor beta
    monoclonal nonspecific suppressor factor betamonoclonal nonspecific suppressor factor beta
    ubiquitin-like protein FUBI

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001160239.3 → NP_001153711.1  ubiquitin-like FUBI-ribosomal protein eS30 fusion protein

      See identical proteins and their annotated locations for NP_001153711.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 3. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC131692
      Consensus CDS
      CCDS29489.1
      UniProtKB/Swiss-Prot
      P35545, P62862, Q642K5, Q9JJ24
      UniProtKB/TrEMBL
      Q3THB2
      Related
      ENSMUSP00000042835.6, ENSMUST00000043074.14
      Conserved Domains (2) summary
      cd01793
      Location:1 → 74
      Ubl_FUBI; ubiquitin-like (Ubl) domain found in ubiquitin-like protein FUBI and similar proteins
      pfam04758
      Location:75 → 132
      Ribosomal_S30; Ribosomal protein S30

    2. NM_001190436.2 → NP_001177365.1  ubiquitin-like FUBI-ribosomal protein eS30 fusion protein

      See identical proteins and their annotated locations for NP_001177365.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC131692
      Consensus CDS
      CCDS29489.1
      UniProtKB/Swiss-Prot
      P35545, P62862, Q642K5, Q9JJ24
      UniProtKB/TrEMBL
      Q3THB2
      Related
      ENSMUSP00000136358.2, ENSMUST00000179142.2
      Conserved Domains (2) summary
      cd01793
      Location:1 → 74
      Ubl_FUBI; ubiquitin-like (Ubl) domain found in ubiquitin-like protein FUBI and similar proteins
      pfam04758
      Location:75 → 132
      Ribosomal_S30; Ribosomal protein S30

    3. NM_007990.4 → NP_032016.1  ubiquitin-like FUBI-ribosomal protein eS30 fusion protein

      See identical proteins and their annotated locations for NP_032016.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 3. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC131692
      Consensus CDS
      CCDS29489.1
      UniProtKB/Swiss-Prot
      P35545, P62862, Q642K5, Q9JJ24
      UniProtKB/TrEMBL
      Q3THB2
      Related
      ENSMUSP00000136803.2, ENSMUST00000178310.9
      Conserved Domains (2) summary
      cd01793
      Location:1 → 74
      Ubl_FUBI; ubiquitin-like (Ubl) domain found in ubiquitin-like protein FUBI and similar proteins
      pfam04758
      Location:75 → 132
      Ribosomal_S30; Ribosomal protein S30

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      6107977..6109554
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62862.2 GenPept UniProtKB/Swiss-Prot:P62862

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous