Elp1 elongator acetyltransferase complex subunit 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Elp1provided by RGD
Full Name: elongator acetyltransferase complex subunit 1provided by RGD
Primary source: RGD:620072
See related: EnsemblRapid:ENSRNOG00000016725 AllianceGenome:RGD:620072
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ikbkap
Summary: Enables ATP binding activity and protein kinase activity. Involved in I-kappaB phosphorylation. Predicted to be located in cytoplasm. Predicted to be part of elongator holoenzyme complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Riley-Day syndrome; asthma; kyphosis; medulloblastoma; and scoliosis. Orthologous to human ELP1 (elongator acetyltransferase complex subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 190.0), Adrenal (RPKM 185.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q24

Exon count:: 38

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (76248545..76300985, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (71453338..71505833, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (73503406..73552798, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Organ culture of bronchi induces IkappaB kinase mediated inflammatory changes resulting in airway hyperresponsiveness to bradykinin via the up-regulation of bradykinin receptors.
Title: Up-regulation of bradykinin receptors in rat bronchi via I kappa B kinase-mediated inflammatory signaling pathway.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ikbkap (e-PCR), detects polymorphism
- UniSTS:234032

AI501954 (e-PCR)
- UniSTS:226233

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables tRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in I-kappaB phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA wobble uridine modification	IEA Inferred from Electronic Annotation more info
involved_in tRNA wobble uridine modification	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of elongator holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info
part_of elongator holoenzyme complex	IEA Inferred from Electronic Annotation more info
part_of elongator holoenzyme complex	ISO Inferred from Sequence Orthology more info
part_of elongator holoenzyme complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: elongator complex protein 1

Names: IKK complex-associated protein; elongator complex protein 1-like; ikappaB kinase complex-associated protein; inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080899.2 → NP_543175.2 elongator complex protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q8VHU4

UniProtKB/TrEMBL

A6KDR5, F1LP76

Related

ENSRNOP00000022836.5, ENSRNOT00000022836.7

Conserved Domains (3) summary

COG0457
Location:874 → 1099

TPR; Tetratricopeptide (TPR) repeat [General function prediction only]

sd00039
Location:112 → 147

7WD40; WD40 repeat [structural motif]

pfam04762
Location:1 → 953

IKI3; IKI3 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

76248545..76300985 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109191.2 → XP_038965119.1 elongator complex protein 1 isoform X1

UniProtKB/Swiss-Prot

Q8VHU4

Conserved Domains (3) summary

COG0457
Location:874 → 1099

TPR; Tetratricopeptide (TPR) repeat [General function prediction only]

sd00039
Location:112 → 147

7WD40; WD40 repeat [structural motif]

pfam04762
Location:1 → 953

IKI3; IKI3 family