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    Dynll2 dynein light chain LC8-type 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 140734, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Dynll2provided by RGD
    Official Full Name
    dynein light chain LC8-type 2provided by RGD
    Primary source
    RGD:619860
    See related
    EnsemblRapid:ENSRNOG00000008921 AllianceGenome:RGD:619860
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dlc2
    Summary
    Enables identical protein binding activity and scaffold protein binding activity. Predicted to be involved in cilium assembly. Part of cytoplasmic dynein complex. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human DYNLL2 (dynein light chain LC8-type 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 493.0), Heart (RPKM 303.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dynll2 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (73264260..73283042, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (72767035..72785824, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (75262536..75281302, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 4 subfamily D member 2 Neighboring gene olfactory receptor 1523 Neighboring gene uncharacterized LOC120095169 Neighboring gene serine and arginine rich splicing factor 1 Neighboring gene vascular endothelial zinc finger 1 Neighboring gene CUE domain containing 1 Neighboring gene ribosomal protein L27a, pseudogene 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Fasted/fed states regulate postsynaptic hub protein DYNLL2 and glutamatergic transmission in oxytocin neurons in the hypothalamic paraventricular nucleus. Suyama S, et al. Neuropeptides, 2016 Apr. PMID 26344333
    2. Structure of the monomeric 8-kDa dynein light chain and mechanism of the domain-swapped dimer assembly. Wang W, et al. J Biol Chem, 2003 Oct 17. PMID 12904292
    3. Subcellular localization of PMES-2 proteins regulated by their two cytoskeleton-associated domains. Ninomiya K, et al. Cell Mol Neurobiol, 2005 Aug. PMID 16133941
    4. Myotonia congenita with strabismus in a large family with a mutation in the SCN4A gene. Du H, et al. Eye (Lond), 2012 Aug. PMID 22653516, Free PMC Article
    5. Dynein light chain regulates axonal trafficking and synaptic levels of Bassoon. Fejtova A, et al. J Cell Biol, 2009 Apr 20. PMID 19380881, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC72334

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables scaffold protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in microtubule-based process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in 9+0 non-motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytoplasmic dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytoplasmic dynein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytoplasmic dynein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of dynein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of myosin V complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dynein light chain 2, cytoplasmic
    Names
    dynein light chain-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080697.2 → NP_542428.1  dynein light chain 2, cytoplasmic

      Status: PROVISIONAL

      Source sequence(s)
      BC061874
      UniProtKB/Swiss-Prot
      Q78P75
      UniProtKB/TrEMBL
      A6HHW6
      Related
      ENSRNOP00000012279.3, ENSRNOT00000012279.6
      Conserved Domains (1) summary
      cd21452
      Location:5 → 88
      DLC-like_DYNLL1_DYNLL2; dynein light chain (DLC)-like domain found in the cytoplasmic dynein light chain 1 (DYNLL1) family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      73264260..73283042 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247077.4 → XP_006247139.1  dynein light chain 2, cytoplasmic isoform X1

      UniProtKB/Swiss-Prot
      Q78P75
      UniProtKB/TrEMBL
      A6HHW6
      Conserved Domains (1) summary
      cd21452
      Location:5 → 88
      DLC-like_DYNLL1_DYNLL2; dynein light chain (DLC)-like domain found in the cytoplasmic dynein light chain 1 (DYNLL1) family

    2. XM_039085093.2 → XP_038941021.1  dynein light chain 2, cytoplasmic isoform X1

      UniProtKB/Swiss-Prot
      Q78P75
      UniProtKB/TrEMBL
      A6HHW6
      Conserved Domains (1) summary
      cd21452
      Location:5 → 88
      DLC-like_DYNLL1_DYNLL2; dynein light chain (DLC)-like domain found in the cytoplasmic dynein light chain 1 (DYNLL1) family

    3. XM_063268351.1 → XP_063124421.1  dynein light chain 2, cytoplasmic isoform X1

      UniProtKB/Swiss-Prot
      Q78P75
      UniProtKB/TrEMBL
      A6HHW6
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q78P75.1 GenPept UniProtKB/Swiss-Prot:Q78P75

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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