Rcan2 regulator of calcineurin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rcan2provided by RGD
Official Full Name: regulator of calcineurin 2provided by RGD
Primary source: RGD:69198
See related: EnsemblRapid:ENSRNOG00000010350 AllianceGenome:RGD:69198
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dcip2; Zaki-4; Dscr1l1
Summary: Predicted to enable calcium-dependent protein serine/threonine phosphatase regulator activity. Predicted to be involved in calcium-mediated signaling. Predicted to act upstream of or within several processes, including calcineurin-NFAT signaling cascade; locomotion involved in locomotory behavior; and short-term memory. Predicted to be active in cytoplasm and nucleus. Orthologous to human RCAN2 (regulator of calcineurin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 880.8), Brain (RPKM 249.8) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q13

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (24456861..24674234, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (16959478..17174823, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (19518568..19749145, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

D9Rat193 (e-PCR), detects polymorphism
- UniSTS:228370

RH133146 (e-PCR)
- UniSTS:216429

D9Rat36 (e-PCR)
- UniSTS:119174

Rcan2 (e-PCR), detects polymorphism
- UniSTS:499086

Dscr1l1 (e-PCR), detects polymorphism
- UniSTS:186516

D9Rat78 (e-PCR)
- UniSTS:119197

D9Got19 (e-PCR)
- UniSTS:113569

BF401166 (e-PCR)
- UniSTS:245418

d9rat66 (e-PCR)
- UniSTS:122550

BF398967 (e-PCR)
- UniSTS:247023

D9Got24 (e-PCR)
- UniSTS:115196

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium-dependent protein serine/threonine phosphatase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Notch signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcineurin-NFAT signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in calcium-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within locomotion involved in locomotory behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to oxidative stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within short-term memory	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: calcipressin-2

Names: Down syndrome critical region gene 1-like 1; Down syndrome critical region gene1-like 1; calcineurin inhibitory protein ZAKI-4; down syndrome candidate region 1-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.