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    Ac-gp64 major budded virus envelope glycoprotein [ Autographa californica nucleopolyhedrovirus ]

    Gene ID: 1403961, updated on 18-Aug-2023

    Summary

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    Gene symbol
    Ac-gp64
    Gene description
    major budded virus envelope glycoprotein
    Locus tag
    ACNVgp129
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Autographa californica nucleopolyhedrovirus
    Lineage
    Viruses; dsDNA viruses, no RNA stage; Baculoviridae; Alphabaculovirus
    Also known as
    AcOrf-128
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    Genomic context

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    Location:
    clone: C6
    Sequence:
    NC_001623.1 (108179..109717, complement)

    NC_001623.1Genomic Context describing neighboring genes Neighboring gene chitinase Neighboring gene viral cathepsin-like protein Neighboring gene viral capsid protein Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001623.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Critical Residues and Contacts within Domain IV of Autographa californica Multiple Nucleopolyhedrovirus GP64 Contribute to Its Refolding during Membrane Fusion. Yu Q, et al. J Virol, 2020 Sep 15. PMID 32699096, Free PMC Article
    2. Autographa californica multiple nucleopolyhedrovirus GP64 protein: Analysis of domain I and V amino acid interactions and membrane fusion activity. Yu Q, et al. Virology, 2016 Jan 15. PMID 26655244
    3. Baculovirus GP64-mediated entry into mammalian cells. Kataoka C, et al. J Virol, 2012 Mar. PMID 22190715, Free PMC Article
    4. A pH-sensitive heparin-binding sequence from Baculovirus gp64 protein is important for binding to mammalian cells but not to Sf9 insect cells. Wu C, et al. J Virol, 2012 Jan. PMID 22072779, Free PMC Article
    5. Baculovirus GP64 disulfide bonds: the intermolecular disulfide bond of Autographa californica multicapsid nucleopolyhedrovirus GP64 is not essential for membrane fusion and virion budding. Li Z, et al. J Virol, 2010 Sep. PMID 20573818, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Critical Residues and Contacts within Domain IV of Autographa californica Multiple Nucleopolyhedrovirus GP64 Contribute to Its Refolding during Membrane Fusion.
      Title: Critical Residues and Contacts within Domain IV of Autographa californica Multiple Nucleopolyhedrovirus GP64 Contribute to Its Refolding during Membrane Fusion.
    2. The authors identified 4 critical residues in domain V (G438, W439, T452, and T456) that are important for membrane fusion, and two residues (G438 and W439) that appear to be important for formation or stability of the pre-fusion conformation of GP64.
      Title: Autographa californica multiple nucleopolyhedrovirus GP64 protein: Analysis of domain I and V amino acid interactions and membrane fusion activity.
    3. Viral GP64 mediated virus entry into the mammalian cells.
      Title: Baculovirus GP64-mediated entry into mammalian cells.
    4. Residues 271 and 292 of gp64 protein is important for binding to mammalian cells but not to Sf9 insect cells.
      Title: A pH-sensitive heparin-binding sequence from Baculovirus gp64 protein is important for binding to mammalian cells but not to Sf9 insect cells.
    5. At late times ME53 formed distinct foci at the cell periphery and colocalized with the major envelope fusion protein GP64 and frequently with VP39 capsid protein, suggesting that these cell membrane regions may represent viral budding sites.
      Title: Immediate-early protein ME53 forms foci and colocalizes with GP64 and the major capsid protein VP39 at the cell membranes of Autographa californica multiple nucleopolyhedrovirus-infected cells.
    6. The intermolecular disulfide bonds of GP64 is not essential for membrane fusion and virion budding.
      Title: Baculovirus GP64 disulfide bonds: the intermolecular disulfide bond of Autographa californica multicapsid nucleopolyhedrovirus GP64 is not essential for membrane fusion and virion budding.
    7. Results suggest that several conserved residues of Autographa californica multicapsid nucleopolyhedrovirus GP64 protein (T463, G460, G462, and G474) were not required for membrane fusion but were important for budding and viral infectivity.
      Title: The pre-transmembrane domain of the Autographa californica multicapsid nucleopolyhedrovirus GP64 protein is critical for membrane fusion and virus infectivity.
    8. amino acids at positions 485 to 487 and 503 to 505 are important for cell surface expression of GP64, while amino acids at positions 483 to 484 and 494 to 496 are important for virus budding
      Title: The Autographa californica multicapsid nucleopolyhedrovirus GP64 protein: analysis of transmembrane domain length and sequence requirements.
    9. These results show that in addition to its basic role in membrane anchoring, the GP64 TM domain is critically important for GP64 trafficking, membrane fusion, virion budding, and virus infectivity.
      Title: Functional analysis of the transmembrane (TM) domain of the Autographa californica multicapsid nucleopolyhedrovirus GP64 protein: substitution of heterologous TM domains.
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    General gene information

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    Homology

    General protein information

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    Preferred Names
    major budded virus envelope glycoprotein
    NP_054158.1
    • 58566 Da primary translation product; the upstream, in-frame, initiation codon at 109769..109771 is not used

    VOG classification

    Description:

    • VOGd0203 [S] Nucleopolyhedrovirus envelope glycoprotein
    • Structural Proteins

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001623.1 Reference assembly

      Range
      108179..109717 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_054158.1 major budded virus envelope glycoprotein [Autographa californica nucleopolyhedrovirus]

      See identical proteins and their annotated locations for NP_054158.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P17501
      UniProtKB/TrEMBL
      Q0GY97
      Conserved Domains (1) summary
      pfam03273
      Location:22 → 510
      Baculo_gp64; Baculovirus gp64 envelope glycoprotein family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17501.2

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