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    Erh ERH mRNA splicing and mitosis factor [ Mus musculus (house mouse) ]

    Gene ID: 13877, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Erhprovided by MGI
    Official Full Name
    ERH mRNA splicing and mitosis factorprovided by MGI
    Primary source
    MGI:MGI:108089
    See related
    Ensembl:ENSMUSG00000021131 AllianceGenome:MGI:108089
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mer; Prei1
    Summary
    Predicted to enable methyl-CpG binding activity. Involved in osteoblast differentiation. Located in membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human ERH (ERH mRNA splicing and mitosis factor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 151.7), CNS E14 (RPKM 121.7) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Erh in Genome Data Viewer
    Location:
    12 C3; 12 36.9 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (80680799..80690616, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (80634021..80644111, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_32643 Neighboring gene predicted gene, 46364 Neighboring gene STARR-seq mESC enhancer starr_32644 Neighboring gene predicted gene, 23817 Neighboring gene STARR-positive B cell enhancer ABC_E4032 Neighboring gene solute carrier family 39 (zinc transporter), member 9 Neighboring gene pleckstrin homology domain containing, family D (with coiled-coil domains) member 1, opposite strand Neighboring gene pleckstrin homology domain containing, family D (with coiled-coil domains) member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The ERH gene regulates migration and invasion in 5637 and T24 bladder cancer cells. Pang K, et al. BMC Cancer, 2019 Mar 12. PMID 30866868, Free PMC Article
    2. Solution structure of the mouse enhancer of rudimentary protein reveals a novel fold. Li H, et al. J Biomol NMR, 2005 Aug. PMID 16211485
    3. RNA binding protein Musashi-1 directly targets Msi2 and Erh during early testis germ cell development and interacts with IPO5 upon translocation to the nucleus. Sutherland JM, et al. FASEB J, 2015 Jul. PMID 25782991
    4. Enhancer of rudimentaryp1, e(r)p1, a highly conserved enhancer of the rudimentary gene. Wojcik E, et al. Genetics, 1994 Dec. PMID 7896098, Free PMC Article
    5. The embryonic RNA helicase gene (ERH): a new member of the DEAD box family of RNA helicases. Sowden J, et al. Biochem J, 1995 Jun 15. PMID 8948440, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Knock-down of ERH gene inhibits metastasis of bladder cancer cells.
      Title: The ERH gene regulates migration and invasion in 5637 and T24 bladder cancer cells.
    2. Through expression studies and utilizing a transgenic Msi1 testis-specific overexpression model, we have identified 2 unique RNA-binding targets of MSI1 in spermatogonia, Msi2 and Erh, and have demonstrated a role for MSI1 in translational regulation.
      Title: RNA binding protein Musashi-1 directly targets Msi2 and Erh during early testis germ cell development and interacts with IPO5 upon translocation to the nucleus.
    3. Molecular model of the protein conformation of the mouse enhancer of rudimentary protein.
      Title: Solution structure of the mouse enhancer of rudimentary protein reveals a novel fold.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC103398, MGC130271, MGC130272

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables methyl-CpG binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables methyl-CpG binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in osteoblast differentiation HDA PubMed 
    Component Evidence Code Pubs
    located_in membrane HDA PubMed 
    part_of methylosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of methylosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    enhancer of rudimentary homolog
    Names
    preimplantation protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347409.2 → NP_001334338.1  enhancer of rudimentary homolog isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is longer and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AA260264, BU704106, BY085611, DV062839
      Consensus CDS
      CCDS83973.1
      UniProtKB/TrEMBL
      G3UW85
      Related
      ENSMUSP00000129620.2, ENSMUST00000166931.2
      Conserved Domains (1) summary
      pfam01133
      Location:22 → 118
      ER; Enhancer of rudimentary

    2. NM_001409595.1 → NP_001396524.1  enhancer of rudimentary homolog isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC134537

    3. NM_007951.5 → NP_031977.1  enhancer of rudimentary homolog isoform 1

      See identical proteins and their annotated locations for NP_031977.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) r encodes the shortest isoform (1).
      Source sequence(s)
      AA260264, BU704106, DV069684
      Consensus CDS
      CCDS36483.1
      UniProtKB/Swiss-Prot
      P84089
      UniProtKB/TrEMBL
      Q4FZH7
      Related
      ENSMUSP00000021559.8, ENSMUST00000021559.14
      Conserved Domains (1) summary
      pfam01133
      Location:2 → 99
      ER; Enhancer of rudimentary

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      80680799..80690616 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P84089.1 GenPept UniProtKB/Swiss-Prot:P84089

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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