Dmtn dematin actin binding protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dmtnprovided by MGI
Official Full Name: dematin actin binding proteinprovided by MGI
Primary source: MGI:MGI:99670
See related: Ensembl:ENSMUSG00000022099 AllianceGenome:MGI:99670
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Epb49; Epb4.9; dematin
Summary: Predicted to enable actin filament binding activity; signaling receptor binding activity; and spectrin binding activity. Involved in several processes, including negative regulation of cell-substrate adhesion; negative regulation of protein phosphorylation; and negative regulation of protein targeting to membrane. Located in several cellular components, including cortical cytoskeleton; perinuclear region of cytoplasm; and postsynaptic density. Is active in synapse. Is expressed in central nervous system; dorsal root ganglion; liver lobe; and sensory organ. Orthologous to human DMTN (dematin actin binding protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in cortex adult (RPKM 39.5), liver E14.5 (RPKM 37.0) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D2; 14 36.32 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (70839624..70873488, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (70602184..70636048, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dematin Regulates Calcium Mobilization, Thrombosis, and Early Akt Activation in Platelets.
Title: Dematin Regulates Calcium Mobilization, Thrombosis, and Early Akt Activation in Platelets.
results demonstrate that dematin plays a critical role in maintaining the fundamental properties of the membrane cytoskeleton complex.
Title: Gene disruption of dematin causes precipitous loss of erythrocyte membrane stability and severe hemolytic anemia.
the headpiece domain of dematin regulates calcium mobilization and signaling in platelets
Title: Headpiece domain of dematin regulates calcium mobilization and signaling in platelets.
remodeling of the host cell directed Plasmodium includes the recruitment of dematin, an actin-binding protein of the erythrocyte membrane skeleton and its repositioning to the parasite
Title: Dematin, a component of the erythrocyte membrane skeleton, is internalized by the malaria parasite and associates with Plasmodium 14-3-3.
These results unveil a new function of dematin as a negative regulator of the RhoA activation pathway with physiological implications for normal and pathogenic signaling pathways.
Title: The headpiece domain of dematin regulates cell shape, motility, and wound healing by modulating RhoA activation.
Dematin is expressed in skin, mostly in dermal fibroblasts and hypodermal adipocytes. Knockout mice lacking dematin exhibit hair loss.
Title: Erythrocyte dematin is a candidate gene for Marie Unna hereditary hypotrichosis and related hairloss disorders.
physiological significance of dematin and demonstrate a role for the headpiece domain in the maintenance of structural integrity and mechanical properties of erythrocytes in vivo.
Title: Headpiece domain of dematin is required for the stability of the erythrocyte membrane.
Dematin plays an essential role in the maintenance of erythrocyte shape and membrane stability; dematin-membrane interaction could link the junctional complex to the plasma membrane in erythroid cells.
Title: Combined deletion of mouse dematin-headpiece and beta-adducin exerts a novel effect on the spectrin-actin junctions leading to erythrocyte fragility and hemolytic anemia.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Fgf17 (e-PCR), detects polymorphism
- UniSTS:516628

AI325486 (e-PCR)
- UniSTS:160410

RH129121 (e-PCR)
- UniSTS:212429

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin binding	ISS Inferred from Sequence or Structural Similarity more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables spectrin binding	ISO Inferred from Sequence Orthology more info
enables spectrin binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
involved_in actin filament bundle assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in actin filament capping	IEA Inferred from Electronic Annotation more info
involved_in cellular response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cAMP	ISS Inferred from Sequence or Structural Similarity more info
involved_in endoplasmic reticulum tubular network organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in erythrocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lamellipodium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell-substrate adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of focal adhesion assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of peptidyl-serine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of peptidyl-threonine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein targeting to membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of substrate adhesion-dependent cell spreading	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fibroblast migration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of wound healing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein-containing complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell shape	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of filopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of filopodium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of lamellipodium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in smooth endoplasmic reticulum calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in actin filament	ISO Inferred from Sequence Orthology more info
located_in actin filament	ISS Inferred from Sequence or Structural Similarity more info
located_in cell projection membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cortical cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in platelet dense tubular network membrane	ISO Inferred from Sequence Orthology more info
located_in platelet dense tubular network membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in smooth endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in spectrin-associated cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in spectrin-associated cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: dematin

Names: erythrocyte membrane protein band 4.9; erythrocyte protein band 4.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252662.1 → NP_001239591.1 dematin isoform 1

See identical proteins and their annotated locations for NP_001239591.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1, 7, 8 and 9 encode the same isoform (1).

Source sequence(s)

AK162866, AK165204, BY601680, BY789340

Consensus CDS

CCDS88708.1

UniProtKB/Swiss-Prot

F8WIF9, Q3TYC5, Q8JZV5, Q9WV69, Q9WVM2

UniProtKB/TrEMBL

Q3UEW2

Related

ENSMUSP00000022694.11, ENSMUST00000022694.17

Conserved Domains (2) summary

smart00153
Location:370 → 405

VHP; Villin headpiece domain

pfam16182
Location:8 → 369

AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
NM_001252663.1 → NP_001239592.1 dematin isoform 2

See identical proteins and their annotated locations for NP_001239592.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an in-frame coding exon in the 3' region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1. Variants 2, 3 and 10 encode the same isoform 2.

Source sequence(s)

AI413696, AK165204, AK165294, BY601680, BY789340

Consensus CDS

CCDS27259.1

UniProtKB/TrEMBL

Q3UEW2

Related

ENSMUSP00000106612.3, ENSMUST00000110984.4

Conserved Domains (2) summary

smart00153
Location:348 → 383

VHP; Villin headpiece domain

pfam16182
Location:24 → 347

AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
NM_001252664.1 → NP_001239593.1 dematin isoform 3

See identical proteins and their annotated locations for NP_001239593.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame coding exon in the 5' region, compared to variant 1. The resulting isoform (3) lacks an internal segment, compared to isoform 1. Variants 4, 11 and 12 encode the same isoform (3).

Source sequence(s)

AI413696, AK158744, AK165204, BY282941, BY601680

Consensus CDS

CCDS88707.1

UniProtKB/TrEMBL

Q3UEW2

Related

ENSMUSP00000154373.2, ENSMUST00000228295.2

Conserved Domains (2) summary

smart00153
Location:345 → 380

VHP; Villin headpiece domain

pfam16182
Location:7 → 344

AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
NM_001252665.1 → NP_001239594.1 dematin isoform 4

See identical proteins and their annotated locations for NP_001239594.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and lacks an in-frame coding exon in the 5' region and an in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (4) lacks two internal segments, compared to isoform 1. Variants 5, 6 and 13 encode the same isoform 4.

Source sequence(s)

AI413696, AK162866, AK165204, BY270342, BY601680

Consensus CDS

CCDS88706.1

UniProtKB/TrEMBL

Q3UEW2

Related

ENSMUSP00000154045.2, ENSMUST00000228824.2

Conserved Domains (2) summary

smart00153
Location:323 → 358

VHP; Villin headpiece domain

pfam16182
Location:3 → 322

AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
NM_001252666.1 → NP_001239595.1 dematin isoform 4

See identical proteins and their annotated locations for NP_001239595.1

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in the 5' UTR and lacks an in-frame coding exon in the 5' region and an in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (4) lacks two internal segments, compared to isoform 1. Variants 5, 6 and 13 encode the same isoform 4.

Source sequence(s)

AI413696, AK165204, BC037021, BY000876, BY601680

Consensus CDS

CCDS88706.1

UniProtKB/TrEMBL

Q3UEW2

Related

ENSMUSP00000153945.2, ENSMUST00000228001.2

Conserved Domains (2) summary

smart00153
Location:323 → 358

VHP; Villin headpiece domain

pfam16182
Location:3 → 322

AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
NM_001360024.1 → NP_001346953.1 dematin isoform 1

Status: VALIDATED

Source sequence(s)

AI413696, AK162866, AK165204, BY270342, BY601680, CJ070069

Consensus CDS

CCDS88708.1

UniProtKB/Swiss-Prot

F8WIF9, Q3TYC5, Q8JZV5, Q9WV69, Q9WVM2

UniProtKB/TrEMBL

Q3UEW2

Conserved Domains (2) summary

smart00153
Location:370 → 405

VHP; Villin headpiece domain

pfam16182
Location:8 → 369

AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
NM_001360025.1 → NP_001346954.1 dematin isoform 1

Status: VALIDATED

Source sequence(s)

AI413696, AK162866, AK165204, BY259253, BY282941, BY601680, CJ070069

Consensus CDS

CCDS88708.1

UniProtKB/Swiss-Prot

F8WIF9, Q3TYC5, Q8JZV5, Q9WV69, Q9WVM2

UniProtKB/TrEMBL

Q3UEW2

Conserved Domains (2) summary

smart00153
Location:370 → 405

VHP; Villin headpiece domain

pfam16182
Location:8 → 369

AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
NM_001360026.1 → NP_001346955.1 dematin isoform 1

Status: VALIDATED

Source sequence(s)

AI413696, AK162866, AK165204, BB873101, BY270342, BY278973, BY601680, CJ070069

Consensus CDS

CCDS88708.1

UniProtKB/Swiss-Prot

F8WIF9, Q3TYC5, Q8JZV5, Q9WV69, Q9WVM2

UniProtKB/TrEMBL

Q3UEW2

Conserved Domains (2) summary

smart00153
Location:370 → 405

VHP; Villin headpiece domain

pfam16182
Location:8 → 369

AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
NM_001360027.1 → NP_001346956.1 dematin isoform 2

Status: VALIDATED

Source sequence(s)

AA510592, AI413696, AK162866, AK165204, BY270342, BY601680, CB527108, CJ070069

Consensus CDS

CCDS27259.1

UniProtKB/TrEMBL

Q3UEW2

Conserved Domains (2) summary

smart00153
Location:348 → 383

VHP; Villin headpiece domain

pfam16182
Location:24 → 347

AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
NM_001360028.1 → NP_001346957.1 dematin isoform 3

Status: VALIDATED

Source sequence(s)

AI413696, AK158744, AK165204, BY270342, BY601680, CX243464

Consensus CDS

CCDS88707.1

UniProtKB/TrEMBL

Q3UEW2

Conserved Domains (2) summary

smart00153
Location:345 → 380

VHP; Villin headpiece domain

pfam16182
Location:7 → 344

AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
NM_001360029.1 → NP_001346958.1 dematin isoform 4

Status: VALIDATED

Source sequence(s)

AI413696, AK162866, AK165204, BE946350, BQ555736, BY601680, BY789340

Consensus CDS

CCDS88706.1

UniProtKB/TrEMBL

Q3UEW2

Conserved Domains (2) summary

smart00153
Location:323 → 358

VHP; Villin headpiece domain

pfam16182
Location:3 → 322

AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
NM_001360030.1 → NP_001346959.1 dematin isoform 3

Status: VALIDATED

Source sequence(s)

AI413696, AK158744, AK165204, BY270342, BY601680, CX243464

Consensus CDS

CCDS88707.1

UniProtKB/TrEMBL

Q3UEW2

Conserved Domains (2) summary

smart00153
Location:345 → 380

VHP; Villin headpiece domain

pfam16182
Location:7 → 344

AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
NM_013514.4 → NP_038542.1 dematin isoform 2

See identical proteins and their annotated locations for NP_038542.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and lacks an in-frame coding exon in the 3' region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1. Variants 2, 3 and 10 encode the same isoform 2.

Source sequence(s)

AC154563

Consensus CDS

CCDS27259.1

UniProtKB/TrEMBL

Q3UEW2

Related

ENSMUSP00000153828.2, ENSMUST00000228009.2

Conserved Domains (2) summary

smart00153
Location:348 → 383

VHP; Villin headpiece domain

pfam16182
Location:24 → 347

AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

70839624..70873488 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158453.1 → XP_036014346.1 dematin isoform X5

UniProtKB/TrEMBL

Q3UEW2

Conserved Domains (2) summary

smart00153
Location:345 → 380

VHP; Villin headpiece domain

pfam16182
Location:7 → 344

AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
XM_036158454.1 → XP_036014347.1 dematin isoform X5

UniProtKB/TrEMBL

Q3UEW2

Conserved Domains (2) summary

smart00153
Location:345 → 380

VHP; Villin headpiece domain

pfam16182
Location:7 → 344

AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
XM_036158451.1 → XP_036014344.1 dematin isoform X4

UniProtKB/TrEMBL

Q3UEW2

Conserved Domains (2) summary

smart00153
Location:364 → 399

VHP; Villin headpiece domain

pfam16182
Location:7 → 363

AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
XM_036158446.1 → XP_036014339.1 dematin isoform X2

UniProtKB/Swiss-Prot

F8WIF9, Q3TYC5, Q8JZV5, Q9WV69, Q9WVM2

UniProtKB/TrEMBL

Q3UEW2

Conserved Domains (2) summary

smart00153
Location:370 → 405

VHP; Villin headpiece domain

pfam16182
Location:8 → 369

AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
XM_036158445.1 → XP_036014338.1 dematin isoform X1

UniProtKB/TrEMBL

Q3UEW2

Conserved Domains (2) summary

smart00153
Location:389 → 424

VHP; Villin headpiece domain

pfam16182
Location:8 → 388

AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
XM_036158448.1 → XP_036014341.1 dematin isoform X4

UniProtKB/TrEMBL

Q3UEW2

Conserved Domains (2) summary

smart00153
Location:364 → 399

VHP; Villin headpiece domain

pfam16182
Location:7 → 363

AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
XM_036158442.1 → XP_036014335.1 dematin isoform X1

UniProtKB/TrEMBL

Q3UEW2

Conserved Domains (2) summary

smart00153
Location:389 → 424

VHP; Villin headpiece domain

pfam16182
Location:8 → 388

AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
XM_036158449.1 → XP_036014342.1 dematin isoform X4

UniProtKB/TrEMBL

Q3UEW2

Conserved Domains (2) summary

smart00153
Location:364 → 399

VHP; Villin headpiece domain

pfam16182
Location:7 → 363

AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
XM_036158443.1 → XP_036014336.1 dematin isoform X1

UniProtKB/TrEMBL

Q3UEW2

Conserved Domains (2) summary

smart00153
Location:389 → 424

VHP; Villin headpiece domain

pfam16182
Location:8 → 388

AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
XM_036158452.1 → XP_036014345.1 dematin isoform X5

UniProtKB/TrEMBL

Q3UEW2

Conserved Domains (2) summary

smart00153
Location:345 → 380

VHP; Villin headpiece domain

pfam16182
Location:7 → 344

AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
XM_036158447.1 → XP_036014340.1 dematin isoform X3

UniProtKB/TrEMBL

Q3UEW2

Conserved Domains (2) summary

smart00153
Location:367 → 402

VHP; Villin headpiece domain

pfam16182
Location:8 → 366

AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
XM_036158441.1 → XP_036014334.1 dematin isoform X1

UniProtKB/TrEMBL

Q3UEW2

Conserved Domains (2) summary

smart00153
Location:389 → 424

VHP; Villin headpiece domain

pfam16182
Location:8 → 388

AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
XM_036158450.1 → XP_036014343.1 dematin isoform X4

UniProtKB/TrEMBL

Q3UEW2

Conserved Domains (2) summary

smart00153
Location:364 → 399

VHP; Villin headpiece domain

pfam16182
Location:7 → 363

AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
XM_036158444.1 → XP_036014337.1 dematin isoform X1

UniProtKB/TrEMBL

Q3UEW2

Conserved Domains (2) summary

smart00153
Location:389 → 424

VHP; Villin headpiece domain

pfam16182
Location:8 → 388

AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM