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    Dtna dystrobrevin alpha [ Mus musculus (house mouse) ]

    Gene ID: 13527, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Dtnaprovided by MGI
    Official Full Name
    dystrobrevin alphaprovided by MGI
    Primary source
    MGI:MGI:106039
    See related
    Ensembl:ENSMUSG00000024302 AllianceGenome:MGI:106039
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dtn; adbn; DTN-A; a-DB-1; Gm19389; 2210407P21Rik
    Summary
    Predicted to enable PDZ domain binding activity and phosphatase binding activity. Predicted to be involved in synaptic signaling. Located in synapse. Is expressed in several structures, including central nervous system; genitourinary system; gut; heart; and sensory organ. Human ortholog(s) of this gene implicated in cardiomyopathy and left ventricular noncompaction. Orthologous to human DTNA (dystrobrevin alpha). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 9.3), cortex adult (RPKM 8.0) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dtna in Genome Data Viewer
    Location:
    18 A2; 18 12.08 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (23443063..23792776)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (23310006..23659719)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22495 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_44038 Neighboring gene STARR-seq mESC enhancer starr_44039 Neighboring gene STARR-seq mESC enhancer starr_44040 Neighboring gene STARR-seq mESC enhancer starr_44041 Neighboring gene STARR-seq mESC enhancer starr_44043 Neighboring gene predicted gene, 47898 Neighboring gene STARR-seq mESC enhancer starr_44045 Neighboring gene predicted gene 15972 Neighboring gene microtubule-associated protein, RP/EB family, member 2 Neighboring gene microRNA 6360

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Plasticity and structural alterations of mitochondria and sarcoplasmic organelles in muscles of mice deficient in alpha-dystrobrevin, a component of the dystrophin-glycoprotein complex.
      Title: Plasticity and structural alterations of mitochondria and sarcoplasmic organelles in muscles of mice deficient in α-dystrobrevin, a component of the dystrophin-glycoprotein complex.
    2. alpha-Dystrobrevin knockout mice have increased motivation for appetitive reward and altered brain cannabinoid receptor 1 expression.
      Title: α-Dystrobrevin knockout mice have increased motivation for appetitive reward and altered brain cannabinoid receptor 1 expression.
    3. Dystrobrevin alpha gene is a direct target of the vitamin D receptor in muscle.
      Title: Dystrobrevin alpha gene is a direct target of the vitamin D receptor in muscle.
    4. Phosphorylation of alpha-dystrobrevin is essential for alphakap accumulation and acetylcholine receptor stability.
      Title: Phosphorylation of α-dystrobrevin is essential for αkap accumulation and acetylcholine receptor stability.
    5. these results demonstrated that, by inhibiting the activity of DTNA-mediated Notch1 axis, miR-374 could protect against myocardial I/R injury in mice after thoracic epidural anesthesia
      Title: Protective role of microRNA-374 against myocardial ischemia-reperfusion injury in mice following thoracic epidural anesthesia by downregulating dystrobrevin alpha-mediated Notch1 axis.
    6. A phosphorylation site on alpha-dystrobrevin-1 is essential for functional interactions with several proteins at the neuromuscular junction.
      Title: Α-Dystrobrevin-1 recruits Grb2 and α-catulin to organize neurotransmitter receptors at the neuromuscular junction.
    7. Alpha-dystrobrevin is a multifunctional protein that increases dystrophin's binding to the dystrophin-glycoprotein complex.
      Title: Dystrobrevin increases dystrophin's binding to the dystrophin-glycoprotein complex and provides protection during cardiac stress.
    8. Loss of alpha dystrobrevin is associated with perturbation in cell cycle progression and nuclei shape.
      Title: Nuclear localization of the dystrophin-associated protein α-dystrobrevin through importin α2/β1 is critical for interaction with the nuclear lamina/maintenance of nuclear integrity.
    9. Ordered disorder of the astrocytic dystrophin-associated protein complex in the norm and pathology.
      Title: Ordered disorder of the astrocytic dystrophin-associated protein complex in the norm and pathology.
    10. alpha-dystrobrevin emerges as a central organizer of dystrophin-associated protein in glial endfeet and a rare example of a glial protein with a role in maintaining BBB function
      Title: Absence of glial α-dystrobrevin causes abnormalities of the blood-brain barrier and progressive brain edema.
    Submit: New GeneRIF Correction See all GeneRIFs (23)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in synaptic signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of dystrobrevin complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in extrinsic component of cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intermediate filament cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in sarcolemma ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sarcolemma TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dystrobrevin alpha
    Names
    alpha-dystrobrevin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285807.1 → NP_001272736.1  dystrobrevin alpha isoform a

      See identical proteins and their annotated locations for NP_001272736.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC111031, AC133182, AC163102, AK019477, BB337232, BY127150
      Consensus CDS
      CCDS89200.1
      UniProtKB/Swiss-Prot
      P97319, Q61498, Q61499, Q9D2N4, Q9QZZ5, Q9WUL9, Q9WUM0
      UniProtKB/TrEMBL
      A0A1Y7VL34
      Related
      ENSMUSP00000152288.2, ENSMUST00000220904.2
      Conserved Domains (3) summary
      COG0419
      Location:422 → 557
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

    2. NM_001285808.1 → NP_001272737.1  dystrobrevin alpha isoform b

      See identical proteins and their annotated locations for NP_001272737.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR and lacks two in-frame exons in the coding region compared to variant 1. The encoded protein (isoform b) is shorter than isoform a.
      Source sequence(s)
      AC111031, AC163102
      UniProtKB/TrEMBL
      I6L9D6
      Conserved Domains (4) summary
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam09068
      Location:16 → 140
      EF-hand_2; EF hand
      pfam09069
      Location:144 → 232
      EF-hand_3; EF-hand
      pfam11068
      Location:414 → 502
      YlqD; YlqD protein

    3. NM_001285810.1 → NP_001272739.1  dystrobrevin alpha isoform c

      See identical proteins and their annotated locations for NP_001272739.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, 3' UTR and has multiple differences in the coding region compared to variant 1. The resulting protein (isoform c) maintains the reading frame, and is shorter compared to isoform a. Variants 3 and 4 encode the same protein.
      Source sequence(s)
      AC163102, AK019477, AK147359, BB337232
      UniProtKB/TrEMBL
      Q3UHJ2, Q3UHP1
      Conserved Domains (3) summary
      COG0419
      Location:368 → 497
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

    4. NM_001285811.1 → NP_001272740.1  dystrobrevin alpha isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, lacks a portion of the 3' coding region and contains an alternate 3' terminal exon. The encoded protein (isoform e) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AC111031, AC133182, AC163102, AW455975
      UniProtKB/TrEMBL
      A0A1Y7VJN9
      Conserved Domains (4) summary
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam09068
      Location:16 → 140
      EF-hand_2; EF hand
      pfam09069
      Location:144 → 232
      EF-hand_3; EF-hand
      pfam11068
      Location:471 → 568
      YlqD; YlqD protein

    5. NM_001285813.1 → NP_001272742.1  dystrobrevin alpha isoform c

      See identical proteins and their annotated locations for NP_001272742.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, 3' UTR and has multiple differences in the coding region compared to variant 1. The resulting protein (isoform c) maintains the reading frame, and is shorter compared to isoform a. Variants 3 and 4 encode the same protein.
      Source sequence(s)
      AK147279, BB337232, BY122991
      UniProtKB/TrEMBL
      Q3UHJ2, Q3UHP1
      Conserved Domains (3) summary
      COG0419
      Location:368 → 497
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

    6. NM_001285817.1 → NP_001272746.1  dystrobrevin alpha isoform d

      See identical proteins and their annotated locations for NP_001272746.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, 3' UTR and lacks three in-frame exons in the coding region compared to variant 1. The encoded protein (isoform d) is shorter than isoform a. Variants 5 and 6 encode the same protein.
      Source sequence(s)
      AC163102, AK019477, AK131649, AK147279, AK147359, BB337232
      Consensus CDS
      CCDS50236.1
      UniProtKB/TrEMBL
      I6L9D6, Q8CFR5
      Conserved Domains (3) summary
      COG0419
      Location:365 → 494
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

    7. NM_001361215.1 → NP_001348144.1  dystrobrevin alpha isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (d) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC111031, AC163102
      Consensus CDS
      CCDS50236.1
      UniProtKB/TrEMBL
      I6L9D6, Q8CFR5
      Conserved Domains (3) summary
      COG0419
      Location:365 → 494
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

    8. NM_001361216.1 → NP_001348145.1  dystrobrevin alpha isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. The resulting protein (isoform g) is shorter than isoform 1.
      Source sequence(s)
      AC111031, AC133182, AC163102
      UniProtKB/TrEMBL
      I6L9D6
      Conserved Domains (4) summary
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      TIGR03752
      Location:388 → 595
      conj_TIGR03752; integrating conjugative element protein, PFL_4705 family
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin
      cl28419
      Location:416 → 486
      SerS; Seryl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

    9. NM_001361217.1 → NP_001348146.1  dystrobrevin alpha isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. The resulting protein (isoform d) is shorter than isoform 1.
      Source sequence(s)
      AC111031, AC133182, AC163102
      Consensus CDS
      CCDS50236.1
      UniProtKB/TrEMBL
      I6L9D6, Q8CFR5
      Conserved Domains (3) summary
      COG0419
      Location:365 → 494
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

    10. NM_010087.4 → NP_034217.2  dystrobrevin alpha isoform f

      See identical proteins and their annotated locations for NP_034217.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR, lacks a portion of the 3' coding region and contains an alternate 3' terminal exon. The encoded protein (isoform f) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AC133182, AK003829, BU700818, BY127150
      Consensus CDS
      CCDS29094.1
      UniProtKB/TrEMBL
      Q8BTD9
      Related
      ENSMUSP00000037475.8, ENSMUST00000047954.15
      Conserved Domains (2) summary
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

    11. NM_207650.4 → NP_997533.1  dystrobrevin alpha isoform d

      See identical proteins and their annotated locations for NP_997533.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, 3' UTR and lacks three in-frame exons in the coding region compared to variant 1. The encoded protein (isoform d) is shorter than isoform a. Variants 5 and 6 encode the same protein.
      Source sequence(s)
      AC111031, AC133182, AC163102
      Consensus CDS
      CCDS50236.1
      UniProtKB/TrEMBL
      I6L9D6, Q8CFR5
      Related
      ENSMUSP00000111498.3, ENSMUST00000115832.4
      Conserved Domains (3) summary
      COG0419
      Location:365 → 494
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      23443063..23792776
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250320.2 → XP_030106180.1  dystrobrevin alpha isoform X7

      UniProtKB/TrEMBL
      I6L9D6, Q8CFR5
      Conserved Domains (3) summary
      COG0419
      Location:365 → 494
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

    2. XM_036160978.1 → XP_036016871.1  dystrobrevin alpha isoform X7

      UniProtKB/TrEMBL
      I6L9D6, Q8CFR5
      Conserved Domains (3) summary
      COG0419
      Location:365 → 494
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

    3. XM_036160979.1 → XP_036016872.1  dystrobrevin alpha isoform X9

      UniProtKB/TrEMBL
      A0A1Y7VJN9
      Related
      ENSMUSP00000152565.2, ENSMUST00000221880.2
      Conserved Domains (3) summary
      COG0419
      Location:365 → 497
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

    4. XM_036160981.1 → XP_036016874.1  dystrobrevin alpha isoform X11

      UniProtKB/TrEMBL
      Q8BTD9
      Conserved Domains (2) summary
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

    5. XM_036160973.1 → XP_036016866.1  dystrobrevin alpha isoform X2

      UniProtKB/Swiss-Prot
      P97319, Q61498, Q61499, Q9D2N4, Q9QZZ5, Q9WUL9, Q9WUM0
      Conserved Domains (3) summary
      COG0419
      Location:425 → 560
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

    6. XM_036160974.1 → XP_036016867.1  dystrobrevin alpha isoform X2

      UniProtKB/Swiss-Prot
      P97319, Q61498, Q61499, Q9D2N4, Q9QZZ5, Q9WUL9, Q9WUM0
      Conserved Domains (3) summary
      COG0419
      Location:425 → 560
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

    7. XM_036160972.1 → XP_036016865.1  dystrobrevin alpha isoform X1

      UniProtKB/Swiss-Prot
      P97319, Q61498, Q61499, Q9D2N4, Q9QZZ5, Q9WUL9, Q9WUM0
      Conserved Domains (3) summary
      COG0419
      Location:425 → 560
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

    8. XM_011246830.1 → XP_011245132.1  dystrobrevin alpha isoform X4

      UniProtKB/Swiss-Prot
      P97319, Q61498, Q61499, Q9D2N4, Q9QZZ5, Q9WUL9, Q9WUM0
      Conserved Domains (4) summary
      PRK05431
      Location:476 → 546
      PRK05431; seryl-tRNA synthetase; Provisional
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      TIGR03752
      Location:448 → 655
      conj_TIGR03752; integrating conjugative element protein, PFL_4705 family
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

    9. XM_017317811.1 → XP_017173300.1  dystrobrevin alpha isoform X4

      UniProtKB/Swiss-Prot
      P97319, Q61498, Q61499, Q9D2N4, Q9QZZ5, Q9WUL9, Q9WUM0
      Conserved Domains (4) summary
      PRK05431
      Location:476 → 546
      PRK05431; seryl-tRNA synthetase; Provisional
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      TIGR03752
      Location:448 → 655
      conj_TIGR03752; integrating conjugative element protein, PFL_4705 family
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

    10. XM_036160976.1 → XP_036016869.1  dystrobrevin alpha isoform X6

      UniProtKB/TrEMBL
      Q3UHJ2, Q3UHP1
      Conserved Domains (3) summary
      COG0419
      Location:368 → 497
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

    11. XM_036160975.1 → XP_036016868.1  dystrobrevin alpha isoform X3

      UniProtKB/Swiss-Prot
      P97319, Q61498, Q61499, Q9D2N4, Q9QZZ5, Q9WUL9, Q9WUM0
      UniProtKB/TrEMBL
      A0A1Y7VL34
      Conserved Domains (3) summary
      COG0419
      Location:422 → 557
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

    12. XM_011246838.1 → XP_011245140.1  dystrobrevin alpha isoform X12

      UniProtKB/Swiss-Prot
      P97319, Q61498, Q61499, Q9D2N4, Q9QZZ5, Q9WUL9, Q9WUM0
      Conserved Domains (4) summary
      PRK05431
      Location:473 → 543
      PRK05431; seryl-tRNA synthetase; Provisional
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      TIGR03752
      Location:445 → 652
      conj_TIGR03752; integrating conjugative element protein, PFL_4705 family
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

    13. XM_011246833.1 → XP_011245135.1  dystrobrevin alpha isoform X5

      UniProtKB/Swiss-Prot
      P97319, Q61498, Q61499, Q9D2N4, Q9QZZ5, Q9WUL9, Q9WUM0
      Conserved Domains (4) summary
      PRK05431
      Location:447 → 517
      PRK05431; seryl-tRNA synthetase; Provisional
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      TIGR03752
      Location:419 → 626
      conj_TIGR03752; integrating conjugative element protein, PFL_4705 family
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

    14. XM_030250321.1 → XP_030106181.1  dystrobrevin alpha isoform X8

      UniProtKB/TrEMBL
      A0A1Y7VJN9
      Conserved Domains (3) summary
      COG0419
      Location:368 → 503
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

    15. XM_030250323.1 → XP_030106183.1  dystrobrevin alpha isoform X10

      Conserved Domains (2) summary
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16249
      Location:54 → 214
      EFh_DTNA; EF-hand-like motif found in alpha-dystrobrevin

    RNA

    1. XR_004939817.1 RNA Sequence

    2. XR_004939831.1 RNA Sequence

    3. XR_004939818.1 RNA Sequence

    4. XR_004939822.1 RNA Sequence

    5. XR_004939834.1 RNA Sequence

    6. XR_004939821.1 RNA Sequence

    7. XR_004939826.1 RNA Sequence

    8. XR_003952501.2 RNA Sequence

    9. XR_004939823.1 RNA Sequence

    10. XR_004939819.1 RNA Sequence

    11. XR_004939820.1 RNA Sequence

    12. XR_004939816.1 RNA Sequence

    13. XR_004939824.1 RNA Sequence

    14. XR_004939830.1 RNA Sequence

    15. XR_003952500.2 RNA Sequence

    16. XR_004939825.1 RNA Sequence

    17. XR_004939832.1 RNA Sequence

    18. XR_004939833.1 RNA Sequence

    19. XR_004939815.1 RNA Sequence

    20. XR_003952492.1 RNA Sequence

    21. XR_004939827.1 RNA Sequence

    22. XR_001782340.1 RNA Sequence

    23. XR_004939829.1 RNA Sequence

    24. XR_001782342.1 RNA Sequence

    25. XR_004939828.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D2N4.2 GenPept UniProtKB/Swiss-Prot:Q9D2N4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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