Slc29a2 solute carrier family 29 (nucleoside transporters), member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc29a2provided by MGI
Official Full Name: solute carrier family 29 (nucleoside transporters), member 2provided by MGI
Primary source: MGI:MGI:1345278
See related: Ensembl:ENSMUSG00000024891 AllianceGenome:MGI:1345278
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ent2; Der12; Hnp36; mENT2
Summary: Enables neurotransmitter transmembrane transporter activity; purine nucleoside transmembrane transporter activity; and uridine transmembrane transporter activity. Involved in neurotransmitter uptake and nucleoside transport. Acts upstream of or within nucleoside transport. Is active in plasma membrane. Orthologous to human SLC29A2 (solute carrier family 29 member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 8.0), heart adult (RPKM 7.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 4.23 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (5069085..5082000)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (5019057..5031972)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Critical Role of Equilibrative Nucleoside Transporter-2 in Modulating Cerebral Damage and Vascular Dysfunction in Mice with Brain Ischemia-Reperfusion.
Title: The Critical Role of Equilibrative Nucleoside Transporter-2 in Modulating Cerebral Damage and Vascular Dysfunction in Mice with Brain Ischemia-Reperfusion.
Deletion of equilibrative nucleoside transporter 2 disturbs energy metabolism and exacerbates disease progression in an experimental model of Huntington's disease.
Title: Deletion of equilibrative nucleoside transporter 2 disturbs energy metabolism and exacerbates disease progression in an experimental model of Huntington's disease.
Amelioration of lipopolysaccharide-induced memory impairment in equilibrative nucleoside transporter-2 knockout mice is accompanied by the changes in glutamatergic pathways.
Title: Amelioration of lipopolysaccharide-induced memory impairment in equilibrative nucleoside transporter-2 knockout mice is accompanied by the changes in glutamatergic pathways.
Deletion of equilibrative nucleoside transporter-2 protects against lipopolysaccharide-induced neuroinflammation and blood-brain barrier dysfunction in mice.
Title: Deletion of equilibrative nucleoside transporter-2 protects against lipopolysaccharide-induced neuroinflammation and blood-brain barrier dysfunction in mice.
ENT1/2 chemical inhibition and ENT1 knockout prevented P. aeruginosa-induced lung NLRP3 inflammasome activation.
Title: Blockade of equilibrative nucleoside transporter 1/2 protects against Pseudomonas aeruginosa-induced acute lung injury and NLRP3 inflammasome activation.
Studies in mice with intestinal mucosa-specific deletion of Ent2 and the A2B receptor demonstrate a significant effect of intestinal epithelial Ent2 inhibition and A2B receptor signaling in protecting the colonic mucosal barrier and suggest that a coordinated network of adenosine transport and signaling between Ent2 and the A2B receptor exists at the epithelial surface that can be pharmacologically targeted in colitis.
Title: Coordination of ENT2-dependent adenosine transport and signaling dampens mucosal inflammation.
Data suggest that crosstalk pathway between ENT2 and alveolar epithelial Adora2b in lung protection during acute lung injury (ALI) opens possibilities for combined therapies targeted to this protein set.
Title: Crosstalk between the equilibrative nucleoside transporter ENT2 and alveolar Adora2b adenosine receptors dampens acute lung injury.
these findings reveal the transcriptional repression of ENT1,2 as an innate protective response during acute pulmonary inflammation.
Title: Repression of the equilibrative nucleoside transporters dampens inflammatory lung injury.
HIF-1alpha-dependent repression of ENT2 increases mucosal adenosine signaling and attenuates hypoxia-associated inflammation of the intestine.
Title: Hypoxia-inducible factor-dependent repression of equilibrative nucleoside transporter 2 attenuates mucosal inflammation during intestinal hypoxia.
Inosine and ENT-2 contribute to hypoxic preconditioning in the murine cardiomyocyte HL-1 cell line.
Title: Inosine and equilibrative nucleoside transporter 2 contribute to hypoxic preconditioning in the murine cardiomyocyte HL-1 cell line.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:225235

Slc29a2 (e-PCR), detects polymorphism
- UniSTS:547068

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables adenine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables adenine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables cytidine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables cytidine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables guanine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables guanine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables neurotransmitter transmembrane transporter activity	IGI Inferred from Genetic Interaction more info	PubMed
enables neurotransmitter transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables nucleobase transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables nucleobase transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables nucleoside transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleoside transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables nucleoside transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables purine nucleoside transmembrane transporter activity	IGI Inferred from Genetic Interaction more info	PubMed
enables purine nucleoside transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables uracil transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables uracil transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables uridine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables uridine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables uridine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in adenine transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenine transport	ISO Inferred from Sequence Orthology more info
involved_in adenine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in adenosine transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in adenosine transport	ISO Inferred from Sequence Orthology more info
involved_in adenosine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in cytidine transport	ISO Inferred from Sequence Orthology more info
involved_in cytidine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in guanine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in guanine transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in guanine transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in guanine transport	ISO Inferred from Sequence Orthology more info
involved_in hypoxanthine transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in hypoxanthine transport	ISO Inferred from Sequence Orthology more info
involved_in hypoxanthine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in inosine transport	ISO Inferred from Sequence Orthology more info
involved_in inosine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in neurotransmitter transport	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter uptake	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nucleobase transport	ISO Inferred from Sequence Orthology more info
involved_in nucleobase transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in nucleoside transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in nucleoside transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nucleoside transport	IDA Inferred from Direct Assay more info	PubMed
involved_in nucleoside transport	ISO Inferred from Sequence Orthology more info
involved_in purine nucleobase transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in purine nucleobase transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in purine nucleoside transmembrane transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in purine nucleoside transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in pyrimidine-containing compound transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in thymine transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in thymine transport	ISO Inferred from Sequence Orthology more info
involved_in thymine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in uracil transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in uracil transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in uridine transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in uridine transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in uridine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in uridine transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IGI Inferred from Genetic Interaction more info	PubMed
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: equilibrative nucleoside transporter 2

Names: 36 kDa hydrophobic nucleolar protein; 36 kDa nucleolar protein HNP36; delayed early response gene 12; delayed-early response protein 12; equilibrative NBMPR-insensitive nucleoside transporter; equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter; nucleoside transporter, ei-type; solute carrier family 29 member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007854.3 → NP_031880.2 equilibrative nucleoside transporter 2

See identical proteins and their annotated locations for NP_031880.2

Status: VALIDATED

Source sequence(s)

BC048958, BF465335

Consensus CDS

CCDS50354.1

UniProtKB/Swiss-Prot

Q61672, Q9JIT8

Related

ENSMUSP00000157780.2, ENSMUST00000236152.2

Conserved Domains (1) summary

TIGR00939
Location:18 → 456

2a57; Equilibrative Nucleoside Transporter (ENT)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

5069085..5082000

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030250738.1 → XP_030106598.1 equilibrative nucleoside transporter 2 isoform X1

UniProtKB/TrEMBL

A0A494BAC3

Conserved Domains (1) summary

TIGR00939
Location:6 → 404

2a57; Equilibrative Nucleoside Transporter (ENT)
XM_030250739.2 → XP_030106599.1 equilibrative nucleoside transporter 2 isoform X1

UniProtKB/TrEMBL

A0A494BAC3

Related

ENSMUSP00000157983.2, ENSMUST00000237371.2

Conserved Domains (1) summary

TIGR00939
Location:6 → 404

2a57; Equilibrative Nucleoside Transporter (ENT)