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    LYZL4 lysozyme like 4 [ Homo sapiens (human) ]

    Gene ID: 131375, updated on 2-Nov-2024

    Summary

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    Official Symbol
    LYZL4provided by HGNC
    Official Full Name
    lysozyme like 4provided by HGNC
    Primary source
    HGNC:HGNC:28387
    See related
    Ensembl:ENSG00000157093 MIM:612750; AllianceGenome:HGNC:28387
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LYC4; LYZA
    Summary
    Lysozymes (see LYZ; MIM 153450), especially C-type lysozymes, are well-recognized bacteriolytic factors widely distributed in the animal kingdom and play a mainly protective role in host defense. LYZL4 is a member of a family of lysozyme-like genes (Zhang et al., 2005 [PubMed 16014814]).[supplied by OMIM, Apr 2009]
    Expression
    Restricted expression toward testis (RPKM 6.7) See more
    Orthologs
    mouse all
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    Genomic context

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    See LYZL4 in Genome Data Viewer
    Location:
    3p22.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (42360764..42410610, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (42378784..42445904, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (42438575..42452102, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene spalt like transcription factor 4 pseudogene 6 Neighboring gene eukaryotic translation initiation factor 4B pseudogene 4 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:42411131-42411759 Neighboring gene NANOG hESC enhancer GRCh37_chr3:42426849-42427356 Neighboring gene uncharacterized LOC124909371 Neighboring gene ribosomal protein L35a pseudogene 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19745 Neighboring gene uncharacterized LOC124909372 Neighboring gene vasoactive intestinal peptide receptor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of three novel lysozyme-like genes, predominantly expressed in the male reproductive system of humans, belonging to the c-type lysozyme/alpha-lactalbumin family. Zhang K, et al. Biol Reprod, 2005 Nov. PMID 16014814
    2. Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. McClay JL, et al. Neuropsychopharmacology, 2011 Feb. PMID 21107309, Free PMC Article
    3. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. Chen Y, et al. Mol Cell Proteomics, 2013 Oct. PMID 23824909, Free PMC Article
    4. Proteomic characterization of the human sperm nucleus. de Mateo S, et al. Proteomics, 2011 Jul. PMID 21630459
    5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC26768, 1810009N24Rik

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables lysozyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    NOT involved_in defense response to bacterium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in fertilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in fusion of sperm to egg plasma membrane involved in single fertilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in acrosomal vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in acrosomal vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in sperm flagellum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm flagellum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    lysozyme-like protein 4
    Names
    lysozyme A
    lysozyme-4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304386.2 → NP_001291315.1  lysozyme-like protein 4 precursor

      See identical proteins and their annotated locations for NP_001291315.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC092048, BC016747, BX282166, HY037577
      Consensus CDS
      CCDS2697.1
      UniProtKB/Swiss-Prot
      Q96KX0
      UniProtKB/TrEMBL
      A0A080YUZ5
      Related
      ENSP00000387897.1, ENST00000441172.1
      Conserved Domains (1) summary
      cd16897
      Location:21 → 144
      LYZ_C; C-type lysozyme

    2. NM_144634.4 → NP_653235.1  lysozyme-like protein 4 precursor

      See identical proteins and their annotated locations for NP_653235.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC092048, BC016747, HY037577
      Consensus CDS
      CCDS2697.1
      UniProtKB/Swiss-Prot
      Q96KX0
      UniProtKB/TrEMBL
      A0A080YUZ5
      Related
      ENSP00000287748.3, ENST00000287748.8
      Conserved Domains (1) summary
      cd16897
      Location:21 → 144
      LYZ_C; C-type lysozyme

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      42360764..42410610 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011533355.4 → XP_011531657.1  lysozyme-like protein 4 isoform X1

      Conserved Domains (1) summary
      cd00119
      Location:20 → 123
      LYZ1; C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      42378784..42445904 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054345215.1 → XP_054201190.1  lysozyme-like protein 4 isoform X1

    2. XM_054345216.1 → XP_054201191.1  lysozyme-like protein 4 isoform X2

      UniProtKB/Swiss-Prot
      Q96KX0
      UniProtKB/TrEMBL
      A0A080YUZ5

    3. XM_054345214.1 → XP_054201189.1  lysozyme-like protein 4 isoform X2

      UniProtKB/Swiss-Prot
      Q96KX0
      UniProtKB/TrEMBL
      A0A080YUZ5

    4. XM_054345213.1 → XP_054201188.1  lysozyme-like protein 4 isoform X2

      UniProtKB/Swiss-Prot
      Q96KX0
      UniProtKB/TrEMBL
      A0A080YUZ5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96KX0.1 GenPept UniProtKB/Swiss-Prot:Q96KX0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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