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    Cyp2c39 cytochrome P450, family 2, subfamily c, polypeptide 39 [ Mus musculus (house mouse) ]

    Gene ID: 13098, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cyp2c39provided by MGI
    Official Full Name
    cytochrome P450, family 2, subfamily c, polypeptide 39provided by MGI
    Primary source
    MGI:MGI:1306818
    See related
    Ensembl:ENSMUSG00000025003 AllianceGenome:MGI:1306818
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CYPIIC39
    Summary
    Enables arachidonate 11,12-epoxygenase activity. Involved in arachidonate metabolic process. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in liver. Human ortholog(s) of this gene implicated in several diseases, including Plasmodium falciparum malaria; carcinoma (multiple); end stage renal disease; glucose metabolism disease (multiple); and hypertension (multiple). Orthologous to several human genes including CYP2C18 (cytochrome P450 family 2 subfamily C member 18); CYP2C19 (cytochrome P450 family 2 subfamily C member 19); and CYP2C9 (cytochrome P450 family 2 subfamily C member 9). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward liver adult (RPKM 56.8) See more
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    Genomic context

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    See Cyp2c39 in Genome Data Viewer
    Location:
    19 C3; 19 34.15 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (39335790..39558012)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (39347346..39569568)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 53, pseudogene Neighboring gene STARR-seq mESC enhancer starr_46111 Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 29 Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 72, pseudogene Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 38 Neighboring gene STARR-seq mESC enhancer starr_46112 Neighboring gene STARR-seq mESC enhancer starr_46113 Neighboring gene STARR-seq mESC enhancer starr_46114 Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 67 Neighboring gene STARR-seq mESC enhancer starr_46115 Neighboring gene STARR-seq mESC enhancer starr_46116 Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 68

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse liver CYP2C39 is a novel retinoic acid 4-hydroxylase. Its down-regulation offers a molecular basis for liver retinoid accumulation and fibrosis in aryl hydrocarbon receptor-null mice. Andreola F, et al. J Biol Chem, 2004 Jan 30. PMID 14623888
    2. A comparative analysis of binding sites between mouse CYP2C38 and CYP2C39 based on homology modeling, molecular dynamics simulation and docking studies. Meng XY, et al. Biochim Biophys Acta, 2009 Jul. PMID 19358898
    3. Mouse Cyp2c expression and zonation structure in the liver begins in the early neonatal stage. Kawamura T, et al. Biopharm Drug Dispos, 2022 Aug. PMID 35748067
    4. Altered vitamin A homeostasis and increased size and adiposity in the rdh1-null mouse. Zhang M, et al. FASEB J, 2007 Sep. PMID 17435174
    5. Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid. Luo G, et al. Arch Biochem Biophys, 1998 Sep 1. PMID 9721182

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. By comparison of active site architectures between CYP2C38 and CYP2C39, the possible reasons affecting their substrate binding were proposed
      Title: A comparative analysis of binding sites between mouse CYP2C38 and CYP2C39 based on homology modeling, molecular dynamics simulation and docking studies.
    2. CYP2C39 is a novel retinoic acid 4-hydroxylase
      Title: Mouse liver CYP2C39 is a novel retinoic acid 4-hydroxylase. Its down-regulation offers a molecular basis for liver retinoid accumulation and fibrosis in aryl hydrocarbon receptor-null mice.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables arachidonate 11,12-epoxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables arachidonate 14,15-epoxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables arachidonate epoxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arachidonate epoxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables aromatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables caffeine oxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables estrogen 16-alpha-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables long-chain fatty acid omega-1 hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables retinoic acid 4-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables steroid hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in arachidonate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in arachidonate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in epoxygenase P450 pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in xenobiotic metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 2C39
    Names
    cytochrome P450, 2c39
    NP_001360866.1
    NP_034133.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001373937.1 → NP_001360866.1  cytochrome P450 2C39 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC117790, AC139233
      UniProtKB/TrEMBL
      Q6PER7
      Conserved Domains (1) summary
      pfam00067
      Location:30 → 487
      p450; Cytochrome P450

    2. NM_010003.2 → NP_034133.2  cytochrome P450 2C39 isoform 1 precursor

      See identical proteins and their annotated locations for NP_034133.2

      Status: VALIDATED

      Source sequence(s)
      AC117790, AC139233
      Consensus CDS
      CCDS29795.1
      UniProtKB/Swiss-Prot
      B9EIA6, G5E854, P56656
      UniProtKB/TrEMBL
      Q6PER7
      Related
      ENSMUSP00000025968.5, ENSMUST00000025968.5
      Conserved Domains (1) summary
      pfam00067
      Location:30 → 487
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      39335790..39558012
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P56656.2 GenPept UniProtKB/Swiss-Prot:P56656

    Gene LinkOut

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