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    Crabp2 cellular retinoic acid binding protein II [ Mus musculus (house mouse) ]

    Gene ID: 12904, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Crabp2provided by MGI
    Official Full Name
    cellular retinoic acid binding protein IIprovided by MGI
    Primary source
    MGI:MGI:88491
    See related
    Ensembl:ENSMUSG00000004885 AllianceGenome:MGI:88491
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Crabp-2; CrabpII
    Summary
    Enables retinoic acid binding activity. Acts upstream of or within embryonic forelimb morphogenesis; positive regulation of collateral sprouting; and retinoic acid metabolic process. Located in endoplasmic reticulum and nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; heart and pericardium; and sensory organ. Orthologous to human CRABP2 (cellular retinoic acid binding protein 2). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in CNS E11.5 (RPKM 125.3), limb E14.5 (RPKM 55.3) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Crabp2 in Genome Data Viewer
    Location:
    3 F1; 3 38.78 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (87856000..87860679)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (87948693..87953372)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10190 Neighboring gene mitochondrial ribosomal protein L24 Neighboring gene methyltransferase like 25B Neighboring gene STARR-positive B cell enhancer ABC_E9556 Neighboring gene interferon stimulated exonuclease gene 20-like 2 Neighboring gene STARR-positive B cell enhancer ABC_E9216 Neighboring gene predicted gene, 32518 Neighboring gene predicted gene 3745

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of CRABP-II Characterizes Human Skin Poorly Differentiated Squamous Cell Carcinomas and Favors DMBA/TPA-Induced Carcinogenesis. Passeri D, et al. J Invest Dermatol, 2016 Jun. PMID 26945879
    2. Overcoming retinoic acid-resistance of mammary carcinomas by diverting retinoic acid from PPARbeta/delta to RAR. Schug TT, et al. Proc Natl Acad Sci U S A, 2008 May 27. PMID 18495924, Free PMC Article
    3. Repression of cellular retinoic acid-binding protein II during adipocyte differentiation. Berry DC, et al. J Biol Chem, 2010 May 14. PMID 20228061, Free PMC Article
    4. Mice deficient in cellular retinoic acid binding protein II (CRABPII) or in both CRABPI and CRABPII are essentially normal. Lampron C, et al. Development, 1995 Feb. PMID 7768191
    5. LIF removal increases CRABPI and CRABPII transcripts in embryonic stem cells cultured in retinol or 4-oxoretinol. Lane MA, et al. Mol Cell Endocrinol, 2008 Jan 2. PMID 18006143, Free PMC Article

    See all (90) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Crabp2 Promotes Metastasis of Lung Cancer Cells via HuR and Integrin beta1/FAK/ERK Signaling.
      Title: Crabp2 Promotes Metastasis of Lung Cancer Cells via HuR and Integrin β1/FAK/ERK Signaling.
    2. In a study of mice and human skin, data strongly supports the hypothesis that a reduction of CRABP-II expression accelerates and promotes skin aging, and suggests CRABP-II as a novel target to improve the efficacy of retinoid-mediated antiaging therapies.
      Title: Cellular retinoic acid binding protein-II expression and its potential role in skin aging.
    3. The anticarcinogenic activities of CRABP2 are mediated by both HuR and RAR.
      Title: Cellular retinoic acid-binding protein 2 inhibits tumor growth by two distinct mechanisms.
    4. Results show that acetylation status of CRABPII directly influences embryonic stem cell differentiation in response to retinoic acid.
      Title: SIRT1-mediated deacetylation of CRABPII regulates cellular retinoic acid signaling and modulates embryonic stem cell differentiation.
    5. CRABP2 controls mRNA stabilization by HuR.
      Title: Transcript stabilization by the RNA-binding protein HuR is regulated by cellular retinoic acid-binding protein 2.
    6. all three proteins (RDH10, RALDH2, and CRABP2) appeared to be required for ATRA production induced by activation of PPARgamma
      Title: RDH10, RALDH2, and CRABP2 are required components of PPARγ-directed ATRA synthesis and signaling in human dendritic cells.
    7. CRABP2 promotes myoblast differentiation and is modulated by the transcription factors MyoD and Sp1 in C2C12 cells.
      Title: CRABP2 promotes myoblast differentiation and is modulated by the transcription factors MyoD and Sp1 in C2C12 cells.
    8. observations emphasize the important role of CRABP-II in regulating the transcriptional activity of RA through RAR, and they demonstrate that repression of this gene is critical for allowing adipogenesis to proceed
      Title: Repression of cellular retinoic acid-binding protein II during adipocyte differentiation.
    9. TIS7 inhibits CRABP II expression during axonal regeneration, thereby modulating retinoic acid signalling. Hence, neurite initiation and branching are regulated by a negative feedback mechanism involving TIS7 and CRABP II.
      Title: The transcriptional corepressor TPA-inducible sequence 7 regulates adult axon growth through cellular retinoic acid binding protein II expression.
    10. Increases in CRABPI and II transcripts in the absence of leukemia inhibitory factor may regulate aspects of embryonic stem cell differentiation in response to retinol.
      Title: LIF removal increases CRABPI and CRABPII transcripts in embryonic stem cells cultured in retinol or 4-oxoretinol.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cyclin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fatty acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables retinal binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables retinoic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables retinoic acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables retinoic acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables retinol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryonic forelimb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fatty acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of collateral sprouting IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within retinoic acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cellular retinoic acid-binding protein 2
    Names
    CRABP-II

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007759.2 → NP_031785.1  cellular retinoic acid-binding protein 2

      See identical proteins and their annotated locations for NP_031785.1

      Status: PROVISIONAL

      Source sequence(s)
      AC158233
      Consensus CDS
      CCDS17460.1
      UniProtKB/Swiss-Prot
      P22935
      Related
      ENSMUSP00000005019.6, ENSMUST00000005019.6
      Conserved Domains (1) summary
      cl10502
      Location:3 → 138
      lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      87856000..87860679
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P22935.2 GenPept UniProtKB/Swiss-Prot:P22935

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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