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    SPACA7 sperm acrosome associated 7 [ Homo sapiens (human) ]

    Gene ID: 122258, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SPACA7provided by HGNC
    Official Full Name
    sperm acrosome associated 7provided by HGNC
    Primary source
    HGNC:HGNC:29575
    See related
    Ensembl:ENSG00000153498 AllianceGenome:HGNC:29575
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C13orf28
    Summary
    Predicted to act upstream of or within negative regulation of cell adhesion and single fertilization. Located in acrosomal vesicle. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis (RPKM 19.1) See more
    Orthologs
    mouse all
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    Genomic context

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    See SPACA7 in Genome Data Viewer
    Location:
    13q34
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (112376355..112434689)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (111623523..111681824)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (113030669..113089003)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903250 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr13:113000836-113001624 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113004827-113005327 Neighboring gene uncharacterized LOC105370373 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:113032121-113033320 Neighboring gene uncharacterized LOC105370372 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr13:113046012-113046542 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113161934-113162852 Neighboring gene tubulin gamma complex component 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113233725-113234278 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5530 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5529 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5531 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113242463-113243282 Neighboring gene uncharacterized LOC124903251 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5532 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5533 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113271950-113272450 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113279517-113280017 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113291197-113291866 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:113296973-113297156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113302064-113302958 Neighboring gene ATP11A upstream neighbor lncRNA Neighboring gene Sharpr-MPRA regulatory region 9322

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of a new mouse sperm acrosome-associated protein. Korfanty J, et al. Reproduction, 2012 Jun. PMID 22495889
    2. The DNA sequence and analysis of human chromosome 13. Dunham A, et al. Nature, 2004 Apr 1. PMID 15057823, Free PMC Article
    3. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. Katsogiannou M, et al. Mol Cell Proteomics, 2014 Dec. PMID 25277244, Free PMC Article
    4. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. Luo J, et al. Cell, 2009 May 29. PMID 19490893, Free PMC Article
    5. A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition. Benslimane Y, et al. Aging Cell, 2021 Apr. PMID 33660365, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ27356

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in single fertilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in acrosomal lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sperm acrosome-associated protein 7
    Names
    protein SPACA7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145248.5 → NP_660291.2  sperm acrosome-associated protein 7 precursor

      See identical proteins and their annotated locations for NP_660291.2

      Status: VALIDATED

      Source sequence(s)
      AI219896, AL160033, BC016750
      Consensus CDS
      CCDS9524.1
      UniProtKB/Swiss-Prot
      Q5T8L1, Q96KW9
      Related
      ENSP00000283550.3, ENST00000283550.8
      Conserved Domains (1) summary
      pfam15307
      Location:19 → 125
      SPACA7; Sperm acrosome-associated protein 7

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      112376355..112434689
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011537468.3 → XP_011535770.1  sperm acrosome-associated protein 7 isoform X3

      See identical proteins and their annotated locations for XP_011535770.1

      Conserved Domains (1) summary
      pfam15307
      Location:12 → 111
      SPACA7; Sperm acrosome-associated protein 7

    2. XM_017020392.2 → XP_016875881.1  sperm acrosome-associated protein 7 isoform X8

    3. XM_011537471.3 → XP_011535773.1  sperm acrosome-associated protein 7 isoform X4

      See identical proteins and their annotated locations for XP_011535773.1

      Conserved Domains (1) summary
      pfam15307
      Location:1 → 80
      SPACA7; Sperm acrosome-associated protein 7

    4. XM_011537466.2 → XP_011535768.2  sperm acrosome-associated protein 7 isoform X1

    5. XM_011537472.3 → XP_011535774.2  sperm acrosome-associated protein 7 isoform X5

    6. XM_011537467.3 → XP_011535769.2  sperm acrosome-associated protein 7 isoform X2

    7. XM_024449318.2 → XP_024305086.2  sperm acrosome-associated protein 7 isoform X6

    8. XM_017020391.2 → XP_016875880.2  sperm acrosome-associated protein 7 isoform X7

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187592.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      177325..235659
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328941.1 → XP_054184916.1  sperm acrosome-associated protein 7 isoform X3

    2. XM_054328946.1 → XP_054184921.1  sperm acrosome-associated protein 7 isoform X8

    3. XM_054328942.1 → XP_054184917.1  sperm acrosome-associated protein 7 isoform X4

    4. XM_054328939.1 → XP_054184914.1  sperm acrosome-associated protein 7 isoform X1

    5. XM_054328943.1 → XP_054184918.1  sperm acrosome-associated protein 7 isoform X5

    6. XM_054328940.1 → XP_054184915.1  sperm acrosome-associated protein 7 isoform X2

    7. XM_054328944.1 → XP_054184919.1  sperm acrosome-associated protein 7 isoform X6

    8. XM_054328945.1 → XP_054184920.1  sperm acrosome-associated protein 7 isoform X7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      111623523..111681824
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054374108.1 → XP_054230083.1  sperm acrosome-associated protein 7 isoform X3

    2. XM_054374113.1 → XP_054230088.1  sperm acrosome-associated protein 7 isoform X8

    3. XM_054374109.1 → XP_054230084.1  sperm acrosome-associated protein 7 isoform X4

    4. XM_054374106.1 → XP_054230081.1  sperm acrosome-associated protein 7 isoform X1

    5. XM_054374110.1 → XP_054230085.1  sperm acrosome-associated protein 7 isoform X5

    6. XM_054374107.1 → XP_054230082.1  sperm acrosome-associated protein 7 isoform X2

    7. XM_054374111.1 → XP_054230086.1  sperm acrosome-associated protein 7 isoform X6

    8. XM_054374112.1 → XP_054230087.1  sperm acrosome-associated protein 7 isoform X7

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96KW9.2 GenPept UniProtKB/Swiss-Prot:Q96KW9

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