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    TEX26 testis expressed 26 [ Homo sapiens (human) ]

    Gene ID: 122046, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TEX26provided by HGNC
    Official Full Name
    testis expressed 26provided by HGNC
    Primary source
    HGNC:HGNC:28622
    See related
    Ensembl:ENSG00000175664 AllianceGenome:HGNC:28622
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C13orf26
    Summary
    Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis (RPKM 7.9) See more
    Orthologs
    mouse all
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    Genomic context

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    See TEX26 in Genome Data Viewer
    Location:
    13q12.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (30932656..30975500)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (30154575..30197390)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (31506793..31549637)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene NANOG hESC enhancer GRCh37_chr13:31459446-31460017 Neighboring gene long intergenic non-protein coding RNA 545 Neighboring gene TEX26 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:31481009-31481510 Neighboring gene mesenteric estrogen dependent adipogenesis Neighboring gene uncharacterized LOC105370145 Neighboring gene NANOG hESC enhancer GRCh37_chr13:31557478-31558053 Neighboring gene long intergenic non-protein coding RNA 1066 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:31578926-31579456 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:31579457-31579987 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7548 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr13:31619425-31620624 Neighboring gene uncharacterized LOC124903147 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:31620925-31621454

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of a large set of rare complete human knockouts. Sulem P, et al. Nat Genet, 2015 May. PMID 25807282
    2. Common homozygosity for predicted loss-of-function variants reveals both redundant and advantageous effects of dispensable human genes. Rausell A, et al. Proc Natl Acad Sci U S A, 2020 Jun 16. PMID 32487729, Free PMC Article
    3. The mutational constraint spectrum quantified from variation in 141,456 humans. Karczewski KJ, et al. Nature, 2020 May. PMID 32461654, Free PMC Article
    4. The DNA sequence and analysis of human chromosome 13. Dunham A, et al. Nature, 2004 Apr 1. PMID 15057823, Free PMC Article
    5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2021-02-03)

    ClinGen Genome Curation Page
    Haploinsufficency

    Dosage sensitivity unlikely (Last evaluated 2021-02-03)

    ClinGen Genome Curation PagePubMed

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC40178

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    testis-expressed protein 26
    Names
    testis-expressed sequence 26 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001353388.2 → NP_001340317.1  testis-expressed protein 26 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, 4, and 5 all encode the same isoform (b).
      Source sequence(s)
      AL353680

    2. NM_001353389.2 → NP_001340318.1  testis-expressed protein 26 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, 4, and 5 all encode the same isoform (b).
      Source sequence(s)
      AL353680

    3. NM_001353390.2 → NP_001340319.1  testis-expressed protein 26 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, 4, and 5 all encode the same isoform (b).
      Source sequence(s)
      AL353680

    4. NM_001353391.2 → NP_001340320.1  testis-expressed protein 26 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, 4, and 5 all encode the same isoform (b).
      Source sequence(s)
      AL353680

    5. NM_152325.3 → NP_689538.1  testis-expressed protein 26 isoform a

      See identical proteins and their annotated locations for NP_689538.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AL353680, BC030277
      Consensus CDS
      CCDS9339.1
      UniProtKB/Swiss-Prot
      Q8N6G2
      Related
      ENSP00000369840.3, ENST00000380473.8

    RNA

    1. NR_148425.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks three exons compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AL353680

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      30932656..30975500
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047430094.1 → XP_047286050.1  testis-expressed protein 26 isoform X3

    2. XM_011534925.4 → XP_011533227.1  testis-expressed protein 26 isoform X5

    3. XM_011534926.4 → XP_011533228.1  testis-expressed protein 26 isoform X6

    4. XM_011534919.4 → XP_011533221.1  testis-expressed protein 26 isoform X1

    5. XM_011534924.4 → XP_011533226.1  testis-expressed protein 26 isoform X4

    6. XM_011534921.4 → XP_011533223.1  testis-expressed protein 26 isoform X2

    7. XM_011534927.4 → XP_011533229.1  testis-expressed protein 26 isoform X7

    RNA

    1. XR_001749479.3 RNA Sequence

    2. XR_941493.4 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      30154575..30197390
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054374101.1 → XP_054230076.1  testis-expressed protein 26 isoform X3

    2. XM_054374103.1 → XP_054230078.1  testis-expressed protein 26 isoform X5

    3. XM_054374104.1 → XP_054230079.1  testis-expressed protein 26 isoform X6

    4. XM_054374099.1 → XP_054230074.1  testis-expressed protein 26 isoform X1

    5. XM_054374102.1 → XP_054230077.1  testis-expressed protein 26 isoform X4

    6. XM_054374100.1 → XP_054230075.1  testis-expressed protein 26 isoform X2

    7. XM_054374105.1 → XP_054230080.1  testis-expressed protein 26 isoform X7

    RNA

    1. XR_008488731.1 RNA Sequence

    2. XR_008488732.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N6G2.1 GenPept UniProtKB/Swiss-Prot:Q8N6G2

    Gene LinkOut

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