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    Rhod ras homolog family member D [ Mus musculus (house mouse) ]

    Gene ID: 11854, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Rhodprovided by MGI
    Official Full Name
    ras homolog family member Dprovided by MGI
    Primary source
    MGI:MGI:108446
    See related
    Ensembl:ENSMUSG00000041845 AllianceGenome:MGI:108446
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rho; Arhd; RhoM; RhoHP1
    Summary
    Enables GTP binding activity and protein kinase binding activity. Involved in regulation of actin cytoskeleton organization and regulation of focal adhesion assembly. Acts upstream of or within several processes, including actin filament polymerization; fibroblast growth factor receptor signaling pathway; and protein targeting. Is active in cell projection. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human RHOD (ras homolog family member D). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in small intestine adult (RPKM 37.3), duodenum adult (RPKM 29.7) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rhod in Genome Data Viewer
    Location:
    19 A; 19 4.07 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (4473500..4489562, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (4423472..4439534, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:4294334-4294632 Neighboring gene STARR-positive B cell enhancer ABC_E7626 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:4302085-4302194 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:4302330-4302483 Neighboring gene STARR-positive B cell enhancer ABC_E9988 Neighboring gene G protein-coupled receptor kinase 2 Neighboring gene STARR-seq mESC enhancer starr_45347 Neighboring gene lysine (K)-specific demethylase 2A Neighboring gene RIKEN cDNA 9430078G10 gene Neighboring gene STARR-positive B cell enhancer ABC_E1521 Neighboring gene STARR-seq mESC enhancer starr_45348 Neighboring gene RIKEN cDNA A930001C03 gene Neighboring gene STARR-seq mESC enhancer starr_45349 Neighboring gene synaptotagmin XII Neighboring gene RIKEN cDNA 2010003K11 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Endosome dynamics regulated by a Rho protein. Murphy C, et al. Nature, 1996 Dec 5. PMID 8945468
    2. Rif proteins take to the RhoD: Rho GTPases at the crossroads of actin dynamics and membrane trafficking. Gad AK, et al. Cell Signal, 2010 Feb. PMID 19818399
    3. Atypical Rho GTPases RhoD and Rif integrate cytoskeletal dynamics and membrane trafficking. Aspenström P. Biol Chem, 2014 May. PMID 24622787
    4. Small GTPase RhoD suppresses cell migration and cytokinesis. Tsubakimoto K, et al. Oncogene, 1999 Apr 15. PMID 10229194
    5. The RhoD to centrosomal duplication. Kyrkou A, et al. Small GTPases, 2013 Apr-Jun. PMID 23422264, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RhoD was activated by FGF signaling, and RhoD-activated mDia3C was responsible for the actin filament formation in the protrusion.
      Title: RhoD activated by fibroblast growth factor induces cytoneme-like cellular protrusions through mDia3C.
    2. Lysophosphatidic acid signals through LPA2 receptors and Galphaq proteins of cultured proximal tubule cells to transactivate latent TGF-beta in a Rho/Rho-kinase and alphavbeta6 integrin-dependent manner.
      Title: Lysophosphatidic acid increases proximal tubule cell secretion of profibrotic cytokines PDGF-B and CTGF through LPA2- and Gαq-mediated Rho and αvβ6 integrin-dependent activation of TGF-β.
    3. Podocyte BK(Ca) channels are regulated by synaptopodin, Rho, and actin microfilaments.
      Title: Regulation of podocyte BK(Ca) channels by synaptopodin, Rho, and actin microfilaments.
    4. ERK5 promotes Src-induced podosome formation by inducing RhoGAP7 and thereby limiting Rho activation.
      Title: ERK5 promotes Src-induced podosome formation by limiting Rho activation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament bundle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within actin filament polymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within actin filament polymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell projection assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cell projection assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein targeting IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of focal adhesion assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to fibroblast growth factor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to fibroblast growth factor IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rho-related GTP-binding protein RhoD
    Names
    aplysia ras-related homolog D
    ras homolog D (RhoD)
    ras homolog gene family, member D

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001329989.1 → NP_001316918.1  rho-related GTP-binding protein RhoD isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC124347, AK008880, BX516716
      UniProtKB/TrEMBL
      Q545H8

    2. NM_007485.5 → NP_031511.1  rho-related GTP-binding protein RhoD isoform 1

      See identical proteins and their annotated locations for NP_031511.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC124347, AK008880, BX516716
      Consensus CDS
      CCDS29427.1
      UniProtKB/Swiss-Prot
      O09104, P97348
      UniProtKB/TrEMBL
      Q545H8
      Related
      ENSMUSP00000036031.4, ENSMUST00000048197.10
      Conserved Domains (2) summary
      smart00174
      Location:20 → 192
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
      cd04132
      Location:17 → 208
      Rho4_like; Ras homology family 4 (Rho4) of small guanosine triphosphatases (GTPases)-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      4473500..4489562 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531644.3 → XP_006531707.1  rho-related GTP-binding protein RhoD isoform X1

      See identical proteins and their annotated locations for XP_006531707.1

      UniProtKB/TrEMBL
      G3X9Y4
      Related
      ENSMUSP00000112607.2, ENSMUST00000117462.2
      Conserved Domains (1) summary
      smart00174
      Location:20 → 160
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97348.1 GenPept UniProtKB/Swiss-Prot:P97348

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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