Ank3 ankyrin 3, epithelial [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ank3provided by MGI
Official Full Name: ankyrin 3, epithelialprovided by MGI
Primary source: MGI:MGI:88026
See related: Ensembl:ENSMUSG00000069601 AllianceGenome:MGI:88026
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AnkG; Ank-3; Ankyrin-3; Ankyrin-G; 2900054D09Rik
Summary: This gene encodes a member of the ankyrin protein family. Ankyrins link integral membrane proteins to the spectrin-based cytoskeleton. Ankyrin family members share a protein structure which includes three independently folded domains: the N-terminal ankyrin repeat domain, the central spectrin-binding domain, and the C-terminal rod domain. This ankyrin functions as the major ankyrin in the kidney and may play a role in the polarized distribution of many integral membrane proteins to specific subcellular sites. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression: Broad expression in cerebellum adult (RPKM 12.9), CNS E18 (RPKM 10.5) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B5.3; 10 36.1 cM

Exon count:: 57

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (69234608..69863266)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (69533486..70027436)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hippocampal circAnk3 Deficiency Causes Anxiety-like Behaviors and Social Deficits by Regulating the miR-7080-3p/IQGAP1 Pathway in Mice.
Title: Hippocampal circAnk3 Deficiency Causes Anxiety-like Behaviors and Social Deficits by Regulating the miR-7080-3p/IQGAP1 Pathway in Mice.
Abnormal patterns of sleep and waking behaviors are accompanied by neocortical oscillation disturbances in an Ank3 mouse model of epilepsy-bipolar disorder comorbidity.
Title: Abnormal patterns of sleep and waking behaviors are accompanied by neocortical oscillation disturbances in an Ank3 mouse model of epilepsy-bipolar disorder comorbidity.
The largest isoform of Ankyrin-G is required for lattice structure of the axon initial segment.
Title: The largest isoform of Ankyrin-G is required for lattice structure of the axon initial segment.
Mechanisms and consequences of casein kinase II and ankyrin-3 regulation of the epithelial Na(+) channel.
Title: Mechanisms and consequences of casein kinase II and ankyrin-3 regulation of the epithelial Na(+) channel.
Axonal TAU Sorting Requires the C-terminus of TAU but is Independent of ANKG and TRIM46 Enrichment at the AIS.
Title: Axonal TAU Sorting Requires the C-terminus of TAU but is Independent of ANKG and TRIM46 Enrichment at the AIS.
Ankyrin-G regulates forebrain connectivity and network synchronization via interaction with GABARAP.
Title: Ankyrin-G regulates forebrain connectivity and network synchronization via interaction with GABARAP.
Ankyrin-G induces nucleoporin Nup358 to associate with the axon initial segment of neurons.
Title: Ankyrin-G induces nucleoporin Nup358 to associate with the axon initial segment of neurons.
Results indicate an obligatory role for ankyrin-G protein (AnkG) in lens morphogenesis and growth.
Title: Ankyrin-G regulated epithelial phenotype is required for mouse lens morphogenesis and growth.
ANK3 functions in neuronal microtubule dynamics through GSK3 and its downstream substrate CRMP2.
Title: Disruption of the psychiatric risk gene Ankyrin 3 enhances microtubule dynamics through GSK3/CRMP2 signaling.
Study shows that simultaneous ablation of neuronal Neurofascin and Ankyrin G in young and adult mice reveals age-dependent increase in nodal stability in myelinated axons and differential effects on the lifespan.
Title: Simultaneous Ablation of Neuronal Neurofascin and Ankyrin G in Young and Adult Mice Reveals Age-Dependent Increase in Nodal Stability in Myelinated Axons and Differential Effects on the Lifespan.

Submit: New GeneRIF Correction See all GeneRIFs (42)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Gene trapped (1)
Targeted (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ank3 (e-PCR), detects polymorphism
- UniSTS:141079

D10Mit114 (e-PCR), detects polymorphism
- UniSTS:126013

AI314020 (e-PCR)
- UniSTS:165695

NoName (e-PCR)
- UniSTS:236375

NoName (e-PCR)
- UniSTS:224877

D10Mit32 (e-PCR), detects polymorphism
- UniSTS:116616

D10Mit224 (e-PCR), detects polymorphism
- UniSTS:116617

D11Hjk20 (e-PCR), detects polymorphism
- UniSTS:141741

RH118335 (e-PCR)
- UniSTS:160972

L40632 (e-PCR)
- UniSTS:185834

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cadherin binding	ISO Inferred from Sequence Orthology more info
enables cadherin binding	ISS Inferred from Sequence or Structural Similarity more info
enables cytoskeletal protein binding	ISO Inferred from Sequence Orthology more info
enables cytoskeletal protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphorylation-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables spectrin binding	ISO Inferred from Sequence Orthology more info
enables spectrin binding	ISS Inferred from Sequence or Structural Similarity more info
enables structural constituent of cytoskeleton	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane protein transport	ISO Inferred from Sequence Orthology more info
involved_in anterograde axonal transport	ISO Inferred from Sequence Orthology more info
involved_in axon development	ISO Inferred from Sequence Orthology more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to magnesium ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in clustering of voltage-gated sodium channels	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization	ISO Inferred from Sequence Orthology more info
involved_in establishment or maintenance of microtubule cytoskeleton polarity	ISO Inferred from Sequence Orthology more info
involved_in magnesium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of protein location in cell	ISO Inferred from Sequence Orthology more info
involved_in maintenance of protein location in plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in membrane assembly	ISO Inferred from Sequence Orthology more info
involved_in membrane assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of delayed rectifier potassium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of endocytosis	ISO Inferred from Sequence Orthology more info
involved_in neuromuscular junction development	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuronal action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plasma membrane organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of action potential	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of cation channel activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell communication by electrical coupling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell communication by electrical coupling	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of homotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of homotypic cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of membrane depolarization during cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of membrane depolarization during cardiac muscle cell action potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of membrane potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein targeting to membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein targeting to membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of sodium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sodium ion transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of sodium ion transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sodium ion transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein localization to axon	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to axon	ISO Inferred from Sequence Orthology more info
involved_in protein localization to axon	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of potassium ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein targeting	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in synapse organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in T-tubule	ISO Inferred from Sequence Orthology more info
located_in T-tubule	ISS Inferred from Sequence or Structural Similarity more info
located_in Z disc	ISO Inferred from Sequence Orthology more info
located_in Z disc	ISS Inferred from Sequence or Structural Similarity more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
is_active_in axon initial segment	IBA Inferred from Biological aspect of Ancestor more info
located_in axon initial segment	IDA Inferred from Direct Assay more info	PubMed
located_in axon initial segment	IMP Inferred from Mutant Phenotype more info	PubMed
located_in axon initial segment	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
colocalizes_with bicellular tight junction	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
located_in costamere	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
located_in intercalated disc	IDA Inferred from Direct Assay more info	PubMed
located_in intercalated disc	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
located_in neuromuscular junction	ISS Inferred from Sequence or Structural Similarity more info
located_in node of Ranvier	IDA Inferred from Direct Assay more info	PubMed
located_in node of Ranvier	ISO Inferred from Sequence Orthology more info
located_in paranode region of axon	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in sarcolemma	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	ISS Inferred from Sequence or Structural Similarity more info
located_in sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in sarcoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in spectrin-associated cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in spectrin-associated cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ankyrin-3

Names: brain-specific ankyrin-G

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009670.4 → NP_033800.2 ankyrin-3 isoform g

See identical proteins and their annotated locations for NP_033800.2

Status: REVIEWED

Description

Transcript Variant: This variant (7) utilizes an alternate exon in the 5' coding region and an alternate translation initiation site, compared to variant 2. This results in a shorter isoform (g) and distinct N-terminus, compared to isoform b.

Source sequence(s)

AC132435, L40631

Consensus CDS

CCDS59546.1

UniProtKB/TrEMBL

S4R1X7

Related

ENSMUSP00000138285.2, ENSMUST00000181974.8

Conserved Domains (2) summary

smart00218
Location:116 → 220

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:609 → 692

Death_ank3; Death domain of Ankyrin-3
NM_146005.3 → NP_666117.2 ankyrin-3 isoform b

See identical proteins and their annotated locations for NP_666117.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (b).

Source sequence(s)

AC129018, AC132435, AC156836, L40632

Consensus CDS

CCDS23909.1

UniProtKB/Swiss-Prot

G5E8K4, G5E8K5, O08866, O08867, Q3TSJ8, Q4U205, Q4U206, Q4U256, Q4U260, Q61305, Q61306, Q61307, Q61308, Q61309, Q61310, Q8CBN3, Q8VC68

Related

ENSMUSP00000138326.2, ENSMUST00000182884.8

Conserved Domains (7) summary

smart00218
Location:983 → 1087

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:1476 → 1559

Death_ank3; Death domain of Ankyrin-3

cd00204
Location:443 → 568

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:453 → 544

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:614 → 667

Ank_4; Ankyrin repeats (many copies)

pfam13857
Location:732 → 786

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:448 → 479

ANK; ANK repeat [structural motif]
NM_170687.3 → NP_733788.2 ankyrin-3 isoform f

See identical proteins and their annotated locations for NP_733788.2

Status: REVIEWED

Description

Transcript Variant: This variant (6) utilizes an alternate exon in the 5' coding region and an alternate translation initiation site, compared to variant 2. This results in a shorter isoform (f) and distinct N-terminus, compared to isoform b.

Source sequence(s)

AC132435, AC156836, L40631

Consensus CDS

CCDS23912.1

UniProtKB/TrEMBL

S4R236

Related

ENSMUSP00000090089.5, ENSMUST00000092433.12

Conserved Domains (2) summary

smart00218
Location:116 → 220

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:609 → 692

Death_ank3; Death domain of Ankyrin-3
NM_170688.2 → NP_733789.1 ankyrin-3 isoform c

See identical proteins and their annotated locations for NP_733789.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame segment in the coding region, compared to variant 2. This results in a shorter isoform (c), compared to isoform b.

Source sequence(s)

AC129018, AC132435, AC156836, L40632

UniProtKB/Swiss-Prot

G5E8K5

Conserved Domains (7) summary

smart00218
Location:983 → 1087

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:1476 → 1559

Death_ank3; Death domain of Ankyrin-3

cd00204
Location:443 → 568

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:453 → 544

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:614 → 667

Ank_4; Ankyrin repeats (many copies)

pfam13857
Location:732 → 786

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:448 → 479

ANK; ANK repeat [structural motif]
NM_170689.2 → NP_733790.2 ankyrin-3 isoform d

See identical proteins and their annotated locations for NP_733790.2

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks an alternate in-frame exon in the coding region, compared to variant 2. This results in a shorter isoform (d), compared to isoform b.

Source sequence(s)

AC129018, AC132435, AC156836, L40632

Consensus CDS

CCDS48590.1

UniProtKB/TrEMBL

G5E8K3

Related

ENSMUSP00000090088.6, ENSMUST00000092432.12

Conserved Domains (7) summary

smart00218
Location:965 → 1069

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:1458 → 1541

Death_ank3; Death domain of Ankyrin-3

cd00204
Location:443 → 568

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:453 → 544

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:614 → 667

Ank_4; Ankyrin repeats (many copies)

pfam13857
Location:732 → 786

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:448 → 479

ANK; ANK repeat [structural motif]
NM_170690.2 → NP_733791.2 ankyrin-3 isoform e

See identical proteins and their annotated locations for NP_733791.2

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks an alternate in-frame exon in the coding region, compared to variant 2. This results in a shorter isoform (e), compared to isoform b.

Source sequence(s)

AC129018, AC132435, AC156836, L40632

Consensus CDS

CCDS23910.1

UniProtKB/TrEMBL

G5E8K2

Related

ENSMUSP00000090087.6, ENSMUST00000092431.12

Conserved Domains (7) summary

smart00218
Location:962 → 1066

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:1455 → 1538

Death_ank3; Death domain of Ankyrin-3

cd00204
Location:443 → 568

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:453 → 544

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:614 → 667

Ank_4; Ankyrin repeats (many copies)

pfam13857
Location:732 → 786

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:448 → 479

ANK; ANK repeat [structural motif]
NM_170728.2 → NP_733924.2 ankyrin-3 isoform a

See identical proteins and their annotated locations for NP_733924.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) has multiple differences in the coding region but maintains the reading frame, compared to variant 2. The encoded isoform (a) is shorter, compared to isoform b.

Source sequence(s)

AC129018, AC132435, AC156836, L40632

Consensus CDS

CCDS59545.1

UniProtKB/Swiss-Prot

G5E8K5

Related

ENSMUSP00000138347.2, ENSMUST00000182155.8

Conserved Domains (7) summary

smart00218
Location:944 → 1048

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:1437 → 1520

Death_ank3; Death domain of Ankyrin-3

cd00204
Location:443 → 568

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:453 → 544

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:614 → 667

Ank_4; Ankyrin repeats (many copies)

pfam13857
Location:732 → 786

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:448 → 479

ANK; ANK repeat [structural motif]
NM_170729.2 → NP_733925.2 ankyrin-3 isoform h

See identical proteins and their annotated locations for NP_733925.2

Status: REVIEWED

Description

Transcript Variant: This variant (8) has multiple differences in the coding region but maintains the reading frame, compared to variant 2. This results in a shorter isoform (h), compared to isoform b.

Source sequence(s)

AC129018, AC132435, AC156836, L40632

Consensus CDS

CCDS35931.1

UniProtKB/Swiss-Prot

G5E8K5

Related

ENSMUSP00000061698.9, ENSMUST00000054167.15

Conserved Domains (7) summary

smart00218
Location:944 → 1048

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:1437 → 1520

Death_ank3; Death domain of Ankyrin-3

cd00204
Location:443 → 568

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:453 → 544

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:614 → 667

Ank_4; Ankyrin repeats (many copies)

pfam13857
Location:732 → 786

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:448 → 479

ANK; ANK repeat [structural motif]
NM_170730.2 → NP_733926.2 ankyrin-3 isoform i

See identical proteins and their annotated locations for NP_733926.2

Status: REVIEWED

Description

Transcript Variant: This variant (9) lacks an in-frame segment in the 5' coding region and an in-frame segment in the 3' coding region, compared to variant 2. This results in a shorter isoform (i), compared to isoform b.

Source sequence(s)

AC129018, AC132435, L40632

Consensus CDS

CCDS23911.1

UniProtKB/TrEMBL

G3X971, Q9QXH1

Related

ENSMUSP00000138356.2, ENSMUST00000182439.8

Conserved Domains (2) summary

smart00218
Location:56 → 160

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:549 → 632

Death_ank3; Death domain of Ankyrin-3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

69234608..69863266

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155552.1 → XP_036011445.1 ankyrin-3 isoform X36

UniProtKB/TrEMBL

A0A1W2P812

Related

ENSMUSP00000151906.2, ENSMUST00000218680.2

Conserved Domains (7) summary

smart00218
Location:976 → 1080

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:1469 → 1552

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:363 → 651

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:459 → 490

ANK; ANK repeat [structural motif]

pfam13637
Location:757 → 809

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1302 → 1431

UPA_2; UPA domain

cl39094
Location:545 → 782

Ank_2; Ankyrin repeats (3 copies)
XM_036155538.1 → XP_036011431.1 ankyrin-3 isoform X19

Conserved Domains (7) summary

smart00218
Location:966 → 1070

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:1468 → 1551

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:363 → 651

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:459 → 490

ANK; ANK repeat [structural motif]

pfam13637
Location:757 → 809

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1292 → 1421

UPA_2; UPA domain

cl39094
Location:545 → 782

Ank_2; Ankyrin repeats (3 copies)
XM_036155553.1 → XP_036011446.1 ankyrin-3 isoform X37

Conserved Domains (7) summary

smart00218
Location:966 → 1070

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:1468 → 1551

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:363 → 651

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:459 → 490

ANK; ANK repeat [structural motif]

pfam13637
Location:757 → 809

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1292 → 1421

UPA_2; UPA domain

cl39094
Location:545 → 782

Ank_2; Ankyrin repeats (3 copies)
XM_036155554.1 → XP_036011447.1 ankyrin-3 isoform X38

Conserved Domains (7) summary

smart00218
Location:966 → 1070

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:1468 → 1551

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:363 → 651

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:459 → 490

ANK; ANK repeat [structural motif]

pfam13637
Location:757 → 809

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1292 → 1421

UPA_2; UPA domain

cl39094
Location:545 → 782

Ank_2; Ankyrin repeats (3 copies)
XM_036155557.1 → XP_036011450.1 ankyrin-3 isoform X42

Conserved Domains (7) summary

smart00218
Location:955 → 1059

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:1448 → 1531

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:363 → 651

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:459 → 490

ANK; ANK repeat [structural motif]

pfam13637
Location:757 → 809

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1281 → 1410

UPA_2; UPA domain

cl39094
Location:545 → 782

Ank_2; Ankyrin repeats (3 copies)
XM_036155521.1 → XP_036011414.1 ankyrin-3 isoform X1

Conserved Domains (9) summary

smart00218
Location:1018 → 1155

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:4113 → 4196

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:377 → 665

PHA03095; ankyrin-like protein; Provisional

pfam05109
Location:1542 → 1949

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00045
Location:473 → 504

ANK; ANK repeat [structural motif]

pfam11081
Location:3296 → 3412

DUF2890; Protein of unknown function (DUF2890)

pfam13637
Location:771 → 823

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1377 → 1506

UPA_2; UPA domain

cl39094
Location:559 → 796

Ank_2; Ankyrin repeats (3 copies)
XM_036155522.1 → XP_036011415.1 ankyrin-3 isoform X2

Conserved Domains (9) summary

smart00218
Location:1023 → 1160

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:4118 → 4201

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:377 → 665

PHA03095; ankyrin-like protein; Provisional

pfam05109
Location:1547 → 1954

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00045
Location:473 → 504

ANK; ANK repeat [structural motif]

pfam11081
Location:3301 → 3417

DUF2890; Protein of unknown function (DUF2890)

pfam13637
Location:771 → 823

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1382 → 1511

UPA_2; UPA domain

cl39094
Location:559 → 796

Ank_2; Ankyrin repeats (3 copies)
XM_036155523.1 → XP_036011416.1 ankyrin-3 isoform X3

Conserved Domains (9) summary

smart00218
Location:1023 → 1160

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:4118 → 4201

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:377 → 665

PHA03095; ankyrin-like protein; Provisional

pfam05109
Location:1547 → 1954

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00045
Location:473 → 504

ANK; ANK repeat [structural motif]

pfam11081
Location:3301 → 3417

DUF2890; Protein of unknown function (DUF2890)

pfam13637
Location:771 → 823

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1382 → 1511

UPA_2; UPA domain

cl39094
Location:559 → 796

Ank_2; Ankyrin repeats (3 copies)
XM_036155525.1 → XP_036011418.1 ankyrin-3 isoform X5

Conserved Domains (9) summary

smart00218
Location:1023 → 1160

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:4118 → 4201

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:377 → 665

PHA03095; ankyrin-like protein; Provisional

pfam05109
Location:1547 → 1954

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00045
Location:473 → 504

ANK; ANK repeat [structural motif]

pfam11081
Location:3301 → 3417

DUF2890; Protein of unknown function (DUF2890)

pfam13637
Location:771 → 823

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1382 → 1511

UPA_2; UPA domain

cl39094
Location:559 → 796

Ank_2; Ankyrin repeats (3 copies)
XM_036155526.1 → XP_036011419.1 ankyrin-3 isoform X6

Conserved Domains (9) summary

smart00218
Location:1023 → 1160

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:3689 → 3772

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:377 → 665

PHA03095; ankyrin-like protein; Provisional

pfam05109
Location:1547 → 1954

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00045
Location:473 → 504

ANK; ANK repeat [structural motif]

pfam11081
Location:3301 → 3417

DUF2890; Protein of unknown function (DUF2890)

pfam13637
Location:771 → 823

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1382 → 1511

UPA_2; UPA domain

cl39094
Location:559 → 796

Ank_2; Ankyrin repeats (3 copies)
XM_036155524.1 → XP_036011417.1 ankyrin-3 isoform X4

Conserved Domains (9) summary

smart00218
Location:1023 → 1160

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:4118 → 4201

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:377 → 665

PHA03095; ankyrin-like protein; Provisional

pfam05109
Location:1547 → 1954

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00045
Location:473 → 504

ANK; ANK repeat [structural motif]

pfam11081
Location:3301 → 3417

DUF2890; Protein of unknown function (DUF2890)

pfam13637
Location:771 → 823

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1382 → 1511

UPA_2; UPA domain

cl39094
Location:559 → 796

Ank_2; Ankyrin repeats (3 copies)
XM_036155527.1 → XP_036011420.1 ankyrin-3 isoform X7

Conserved Domains (9) summary

smart00218
Location:1023 → 1160

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:3689 → 3772

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:377 → 665

PHA03095; ankyrin-like protein; Provisional

pfam05109
Location:1547 → 1954

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00045
Location:473 → 504

ANK; ANK repeat [structural motif]

pfam11081
Location:3301 → 3417

DUF2890; Protein of unknown function (DUF2890)

pfam13637
Location:771 → 823

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1382 → 1511

UPA_2; UPA domain

cl39094
Location:559 → 796

Ank_2; Ankyrin repeats (3 copies)
XM_036155528.1 → XP_036011421.1 ankyrin-3 isoform X8

Conserved Domains (9) summary

smart00218
Location:1023 → 1160

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:3689 → 3772

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:377 → 665

PHA03095; ankyrin-like protein; Provisional

pfam05109
Location:1547 → 1954

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00045
Location:473 → 504

ANK; ANK repeat [structural motif]

pfam11081
Location:3301 → 3417

DUF2890; Protein of unknown function (DUF2890)

pfam13637
Location:771 → 823

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1382 → 1511

UPA_2; UPA domain

cl39094
Location:559 → 796

Ank_2; Ankyrin repeats (3 copies)
XM_036155529.1 → XP_036011422.1 ankyrin-3 isoform X9

Conserved Domains (8) summary

smart00218
Location:1023 → 1160

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:2408 → 2491

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:377 → 665

PHA03095; ankyrin-like protein; Provisional

pfam05109
Location:1547 → 1954

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00045
Location:473 → 504

ANK; ANK repeat [structural motif]

pfam13637
Location:771 → 823

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1382 → 1511

UPA_2; UPA domain

cl39094
Location:559 → 796

Ank_2; Ankyrin repeats (3 copies)
XM_036155530.1 → XP_036011423.1 ankyrin-3 isoform X10

Conserved Domains (8) summary

smart00218
Location:1023 → 1160

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:2408 → 2491

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:377 → 665

PHA03095; ankyrin-like protein; Provisional

pfam05109
Location:1547 → 1954

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00045
Location:473 → 504

ANK; ANK repeat [structural motif]

pfam13637
Location:771 → 823

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1382 → 1511

UPA_2; UPA domain

cl39094
Location:559 → 796

Ank_2; Ankyrin repeats (3 copies)
XM_036155531.1 → XP_036011424.1 ankyrin-3 isoform X11

Conserved Domains (8) summary

smart00218
Location:1023 → 1160

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:2406 → 2489

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:377 → 665

PHA03095; ankyrin-like protein; Provisional

pfam05109
Location:1551 → 1952

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00045
Location:473 → 504

ANK; ANK repeat [structural motif]

pfam13637
Location:771 → 823

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1382 → 1511

UPA_2; UPA domain

cl39094
Location:559 → 796

Ank_2; Ankyrin repeats (3 copies)
XM_006513133.4 → XP_006513196.1 ankyrin-3 isoform X12

UniProtKB/TrEMBL

S4R2K9

Related

ENSMUSP00000138686.2, ENSMUST00000182992.8

Conserved Domains (8) summary

smart00218
Location:990 → 1094

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:2333 → 2416

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:377 → 665

PHA03095; ankyrin-like protein; Provisional

pfam05109
Location:1472 → 1879

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00045
Location:473 → 504

ANK; ANK repeat [structural motif]

pfam13637
Location:771 → 823

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1316 → 1445

UPA_2; UPA domain

cl39094
Location:559 → 796

Ank_2; Ankyrin repeats (3 copies)
XM_036155532.1 → XP_036011425.1 ankyrin-3 isoform X13

Conserved Domains (7) summary

smart00218
Location:1023 → 1160

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:1537 → 1620

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:377 → 665

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:473 → 504

ANK; ANK repeat [structural motif]

pfam13637
Location:771 → 823

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1382 → 1511

UPA_2; UPA domain

cl39094
Location:559 → 796

Ank_2; Ankyrin repeats (3 copies)
XM_036155540.1 → XP_036011433.1 ankyrin-3 isoform X22

Conserved Domains (7) summary

smart00218
Location:1023 → 1160

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:1558 → 1641

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:377 → 665

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:473 → 504

ANK; ANK repeat [structural motif]

pfam13637
Location:771 → 823

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1382 → 1511

UPA_2; UPA domain

cl39094
Location:559 → 796

Ank_2; Ankyrin repeats (3 copies)
XM_036155535.1 → XP_036011428.1 ankyrin-3 isoform X16

Conserved Domains (7) summary

smart00218
Location:1012 → 1116

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:1493 → 1576

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:377 → 665

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:473 → 504

ANK; ANK repeat [structural motif]

pfam13637
Location:771 → 823

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1338 → 1467

UPA_2; UPA domain

cl39094
Location:559 → 796

Ank_2; Ankyrin repeats (3 copies)
XM_036155533.1 → XP_036011426.1 ankyrin-3 isoform X14

Conserved Domains (7) summary

smart00218
Location:1008 → 1112

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:1501 → 1584

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:377 → 665

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:473 → 504

ANK; ANK repeat [structural motif]

pfam13637
Location:771 → 823

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1334 → 1463

UPA_2; UPA domain

cl39094
Location:559 → 796

Ank_2; Ankyrin repeats (3 copies)
XM_036155534.1 → XP_036011427.1 ankyrin-3 isoform X15

Conserved Domains (7) summary

smart00218
Location:1001 → 1105

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:1494 → 1577

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:377 → 665

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:473 → 504

ANK; ANK repeat [structural motif]

pfam13637
Location:771 → 823

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1327 → 1456

UPA_2; UPA domain

cl39094
Location:559 → 796

Ank_2; Ankyrin repeats (3 copies)
XM_036155539.1 → XP_036011432.1 ankyrin-3 isoform X21

Conserved Domains (7) summary

smart00218
Location:1023 → 1160

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:1558 → 1641

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:377 → 665

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:473 → 504

ANK; ANK repeat [structural motif]

pfam13637
Location:771 → 823

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1382 → 1511

UPA_2; UPA domain

cl39094
Location:559 → 796

Ank_2; Ankyrin repeats (3 copies)
XM_036155543.1 → XP_036011436.1 ankyrin-3 isoform X25

Conserved Domains (7) summary

smart00218
Location:1023 → 1160

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:1546 → 1629

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:377 → 665

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:473 → 504

ANK; ANK repeat [structural motif]

pfam13637
Location:771 → 823

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1382 → 1511

UPA_2; UPA domain

cl39094
Location:559 → 796

Ank_2; Ankyrin repeats (3 copies)
XM_036155542.1 → XP_036011435.1 ankyrin-3 isoform X24

Conserved Domains (7) summary

smart00218
Location:1023 → 1160

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:1549 → 1632

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:377 → 665

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:473 → 504

ANK; ANK repeat [structural motif]

pfam13637
Location:771 → 823

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1382 → 1511

UPA_2; UPA domain

cl39094
Location:559 → 796

Ank_2; Ankyrin repeats (3 copies)
XM_036155536.1 → XP_036011429.1 ankyrin-3 isoform X17

Conserved Domains (7) summary

smart00218
Location:990 → 1094

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:1483 → 1566

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:377 → 665

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:473 → 504

ANK; ANK repeat [structural motif]

pfam13637
Location:771 → 823

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1316 → 1445

UPA_2; UPA domain

cl39094
Location:559 → 796

Ank_2; Ankyrin repeats (3 copies)
XM_036155537.1 → XP_036011430.1 ankyrin-3 isoform X18

Conserved Domains (7) summary

smart00218
Location:980 → 1084

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:1473 → 1556

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:377 → 665

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:473 → 504

ANK; ANK repeat [structural motif]

pfam13637
Location:771 → 823

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1306 → 1435

UPA_2; UPA domain

cl39094
Location:559 → 796

Ank_2; Ankyrin repeats (3 copies)
XM_006513136.4 → XP_006513199.1 ankyrin-3 isoform X20

Conserved Domains (7) summary

smart00218
Location:969 → 1073

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:1462 → 1545

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:377 → 665

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:473 → 504

ANK; ANK repeat [structural motif]

pfam13637
Location:771 → 823

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1295 → 1424

UPA_2; UPA domain

cl39094
Location:559 → 796

Ank_2; Ankyrin repeats (3 copies)
XM_036155541.1 → XP_036011434.1 ankyrin-3 isoform X23

Conserved Domains (7) summary

smart00218
Location:1023 → 1160

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:1549 → 1632

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:377 → 665

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:473 → 504

ANK; ANK repeat [structural motif]

pfam13637
Location:771 → 823

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1382 → 1511

UPA_2; UPA domain

cl39094
Location:559 → 796

Ank_2; Ankyrin repeats (3 copies)
XM_036155544.1 → XP_036011437.1 ankyrin-3 isoform X26

Conserved Domains (7) summary

smart00218
Location:1023 → 1160

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:1537 → 1620

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:377 → 665

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:473 → 504

ANK; ANK repeat [structural motif]

pfam13637
Location:771 → 823

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1382 → 1511

UPA_2; UPA domain

cl39094
Location:559 → 796

Ank_2; Ankyrin repeats (3 copies)
XM_036155545.1 → XP_036011438.1 ankyrin-3 isoform X27

Conserved Domains (7) summary

smart00218
Location:1023 → 1127

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:1525 → 1608

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:377 → 665

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:473 → 504

ANK; ANK repeat [structural motif]

pfam13637
Location:771 → 823

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1349 → 1478

UPA_2; UPA domain

cl39094
Location:559 → 796

Ank_2; Ankyrin repeats (3 copies)
XM_036155546.1 → XP_036011439.1 ankyrin-3 isoform X28

Conserved Domains (7) summary

smart00218
Location:1023 → 1127

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:1516 → 1599

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:377 → 665

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:473 → 504

ANK; ANK repeat [structural motif]

pfam13637
Location:771 → 823

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1349 → 1478

UPA_2; UPA domain

cl39094
Location:559 → 796

Ank_2; Ankyrin repeats (3 copies)
XM_036155548.1 → XP_036011441.1 ankyrin-3 isoform X30

Conserved Domains (7) summary

smart00218
Location:1012 → 1116

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:1505 → 1588

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:377 → 665

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:473 → 504

ANK; ANK repeat [structural motif]

pfam13637
Location:771 → 823

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1338 → 1467

UPA_2; UPA domain

cl39094
Location:559 → 796

Ank_2; Ankyrin repeats (3 copies)
XM_036155550.1 → XP_036011443.1 ankyrin-3 isoform X33

Conserved Domains (7) summary

smart00218
Location:980 → 1084

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:1482 → 1565

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:377 → 665

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:473 → 504

ANK; ANK repeat [structural motif]

pfam13637
Location:771 → 823

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1306 → 1435

UPA_2; UPA domain

cl39094
Location:559 → 796

Ank_2; Ankyrin repeats (3 copies)
XM_036155547.1 → XP_036011440.1 ankyrin-3 isoform X29

Conserved Domains (7) summary

smart00218
Location:1012 → 1116

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:1505 → 1588

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:377 → 665

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:473 → 504

ANK; ANK repeat [structural motif]

pfam13637
Location:771 → 823

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1338 → 1467

UPA_2; UPA domain

cl39094
Location:559 → 796

Ank_2; Ankyrin repeats (3 copies)
XM_030244846.2 → XP_030100706.1 ankyrin-3 isoform X31

Conserved Domains (7) summary

smart00218
Location:990 → 1094

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:1483 → 1566

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:377 → 665

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:473 → 504

ANK; ANK repeat [structural motif]

pfam13637
Location:771 → 823

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1316 → 1445

UPA_2; UPA domain

cl39094
Location:559 → 796

Ank_2; Ankyrin repeats (3 copies)
XM_036155551.1 → XP_036011444.1 ankyrin-3 isoform X35

Conserved Domains (7) summary

smart00218
Location:990 → 1094

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:1471 → 1554

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:377 → 665

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:473 → 504

ANK; ANK repeat [structural motif]

pfam13637
Location:771 → 823

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1316 → 1445

UPA_2; UPA domain

cl39094
Location:559 → 796

Ank_2; Ankyrin repeats (3 copies)
XM_036155549.1 → XP_036011442.1 ankyrin-3 isoform X32

Conserved Domains (7) summary

smart00218
Location:980 → 1084

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:1482 → 1565

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:377 → 665

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:473 → 504

ANK; ANK repeat [structural motif]

pfam13637
Location:771 → 823

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1306 → 1435

UPA_2; UPA domain

cl39094
Location:559 → 796

Ank_2; Ankyrin repeats (3 copies)
XM_036155556.1 → XP_036011449.1 ankyrin-3 isoform X41

Conserved Domains (7) summary

smart00218
Location:975 → 1079

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:1456 → 1539

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:377 → 665

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:473 → 504

ANK; ANK repeat [structural motif]

pfam13637
Location:771 → 823

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1301 → 1430

UPA_2; UPA domain

cl39094
Location:559 → 796

Ank_2; Ankyrin repeats (3 copies)
XM_017313778.3 → XP_017169267.1 ankyrin-3 isoform X34

Conserved Domains (7) summary

smart00218
Location:982 → 1086

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:1475 → 1558

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:369 → 657

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:465 → 496

ANK; ANK repeat [structural motif]

pfam13637
Location:763 → 815

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1308 → 1437

UPA_2; UPA domain

cl39094
Location:551 → 788

Ank_2; Ankyrin repeats (3 copies)
XM_006513138.4 → XP_006513201.1 ankyrin-3 isoform X40

Conserved Domains (7) summary

smart00218
Location:969 → 1073

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:1462 → 1545

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:377 → 665

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:473 → 504

ANK; ANK repeat [structural motif]

pfam13637
Location:771 → 823

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1295 → 1424

UPA_2; UPA domain

cl39094
Location:559 → 796

Ank_2; Ankyrin repeats (3 copies)
XM_036155555.1 → XP_036011448.1 ankyrin-3 isoform X39

Conserved Domains (7) summary

smart00218
Location:972 → 1076

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:1465 → 1548

Death_ank3; Death domain of Ankyrin-3

PHA03095
Location:369 → 657

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:465 → 496

ANK; ANK repeat [structural motif]

pfam13637
Location:763 → 815

Ank_4; Ankyrin repeats (many copies)

pfam17809
Location:1298 → 1427

UPA_2; UPA domain

cl39094
Location:551 → 788

Ank_2; Ankyrin repeats (3 copies)
XM_006513139.5 → XP_006513202.1 ankyrin-3 isoform X43

UniProtKB/TrEMBL

S4R236

Related

ENSMUSP00000138337.2, ENSMUST00000182029.8

Conserved Domains (3) summary

smart00218
Location:116 → 220

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08803
Location:609 → 692

Death_ank3; Death domain of Ankyrin-3

pfam17809
Location:442 → 571

UPA_2; UPA domain