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    Amy1 amylase 1, salivary [ Mus musculus (house mouse) ]

    Gene ID: 11722, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Amy1provided by MGI
    Official Full Name
    amylase 1, salivaryprovided by MGI
    Primary source
    MGI:MGI:88019
    See related
    Ensembl:ENSMUSG00000074264 AllianceGenome:MGI:88019
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Amy-1; Amy1a; C030014B17Rik
    Summary
    Enables amylase activity. Acts upstream of or within response to bacterium. Located in extracellular space. Is expressed in several structures, including nervous system; pancreas; and submandibular gland. Orthologous to several human genes including AMY2A (amylase alpha 2A) and AMY2B (amylase alpha 2B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver E18 (RPKM 29.9), CNS E18 (RPKM 24.2) and 17 other tissues See more
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    Genomic context

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    See Amy1 in Genome Data Viewer
    Location:
    3 F3; 3 49.35 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (113349601..113371399, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (113555952..113577750, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene amylase 2a2 Neighboring gene amylase 2a1 Neighboring gene STARR-positive B cell enhancer mm9_chr3:113308015-113308316 Neighboring gene RNA-binding region (RNP1, RRM) containing 3 Neighboring gene STARR-positive B cell enhancer mm9_chr3:113332370-113332671 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:113332840-113333141 Neighboring gene ribosomal protein L5 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Multiple polyadenylation sites in a mouse alpha-amylase gene. Tosi M, et al. Nucleic Acids Res, 1981 May 25. PMID 6166922, Free PMC Article
    2. Low Copy Number of the AMY1 Locus Is Associated with Early-Onset Female Obesity in Finland. Viljakainen H, et al. PLoS One, 2015. PMID 26132294, Free PMC Article
    3. Structural forms of the human amylase locus and their relationships to SNPs, haplotypes and obesity. Usher CL, et al. Nat Genet, 2015 Aug. PMID 26098870, Free PMC Article
    4. A salivary amylase transgene is efficiently expressed in liver but not in parotid gland of transgenic mice. Jones JM, et al. Nucleic Acids Res, 1989 Aug 25. PMID 2476716, Free PMC Article
    5. The two promoters of the mouse alpha-amylase gene Amy-1a are differentially activated during parotid gland differentiation. Shaw P, et al. Cell, 1985 Apr. PMID 3872721

    See all (103) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Not Applicable (5)  1 citation
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-amylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-amylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha-amylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables amylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chloride ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    alpha-amylase 1
    Names
    1,4-alpha-D-glucan glucanohydrolase 1
    alpha-amylase amy1a
    salivary and hepatic alpha-amylase
    NP_001103975.1
    NP_031472.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110505.1 → NP_001103975.1  alpha-amylase 1 precursor

      See identical proteins and their annotated locations for NP_001103975.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AA616210, BB462169, CK791844, J00356, V00717, V00720
      Consensus CDS
      CCDS17776.1
      UniProtKB/Swiss-Prot
      P00687, Q921Y7
      Related
      ENSMUSP00000070368.6, ENSMUST00000067980.12
      Conserved Domains (3) summary
      cd11317
      Location:25 → 416
      AmyAc_bac_euk_AmyA; Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase)
      smart00632
      Location:422 → 510
      Aamy_C; Aamy_C domain
      COG0366
      Location:46 → 315
      AmyA; Glycosidase [Carbohydrate transport and metabolism]

    2. NM_007446.2 → NP_031472.2  alpha-amylase 1 precursor

      See identical proteins and their annotated locations for NP_031472.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AA616210, BB462169, CK791844, J00356, V00717, V00719
      Consensus CDS
      CCDS17776.1
      UniProtKB/Swiss-Prot
      P00687, Q921Y7
      Related
      ENSMUSP00000102150.2, ENSMUST00000106540.8
      Conserved Domains (3) summary
      cd11317
      Location:25 → 416
      AmyAc_bac_euk_AmyA; Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase)
      smart00632
      Location:422 → 510
      Aamy_C; Aamy_C domain
      COG0366
      Location:46 → 315
      AmyA; Glycosidase [Carbohydrate transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      113349601..113371399 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P00687.2 GenPept UniProtKB/Swiss-Prot:P00687

    Gene LinkOut

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