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    Sh3bp5 SH3-domain binding protein 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117186, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Sh3bp5provided by RGD
    Official Full Name
    SH3-domain binding protein 5provided by RGD
    Primary source
    RGD:620220
    See related
    EnsemblRapid:ENSRNOG00000052391 AllianceGenome:RGD:620220
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sab; Vesp18; SH3BP-5
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and protein kinase inhibitor activity. Predicted to be involved in intracellular signal transduction and negative regulation of protein kinase activity. Located in mitochondrion. Orthologous to human SH3BP5 (SH3 domain binding protein 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 168.3), Kidney (RPKM 106.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sh3bp5 in Genome Data Viewer
    Location:
    16p16
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (6589877..6676524, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (6583462..6678344, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (7473367..7559976, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene calpain 7 Neighboring gene uncharacterized LOC134482448 Neighboring gene uncharacterized LOC134482449 Neighboring gene methyltransferase 6, tRNA N3-cytidine Neighboring gene ELL associated factor 1 Neighboring gene collagen like tail subunit of asymmetric acetylcholinesterase Neighboring gene uncharacterized LOC134482450

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Bruton's tyrosine kinase activity is negatively regulated by Sab, the Btk-SH3 domain-binding protein. Yamadori T, et al. Proc Natl Acad Sci U S A, 1999 May 25. PMID 10339589, Free PMC Article
    2. Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5. Jenkins ML, et al. Nat Commun, 2018 Sep 14. PMID 30217979, Free PMC Article
    3. Phosphorylation of the mitochondrial protein Sab by stress-activated protein kinase 3. Court NW, et al. Biochem Biophys Res Commun, 2004 Jun 18. PMID 15158451
    4. A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab (SH3BP5), associates with mitochondria. Wiltshire C, et al. Biochem J, 2002 Nov 1. PMID 12167088, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. mitochondrial protein Sab is phosphorylated by stress-activated protein kinase 3
      Title: Phosphorylation of the mitochondrial protein Sab by stress-activated protein kinase 3.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SH3 domain binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in JNK cascade NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SH3 domain-binding protein 5
    Names
    SH3-domain binding protein 5 (BTK-associated)
    vascular endothelial cell-specific protein 18

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_054011.2 → NP_446463.2  SH3 domain-binding protein 5

      See identical proteins and their annotated locations for NP_446463.2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/Swiss-Prot
      Q91Y80
      UniProtKB/TrEMBL
      A6KFZ3, A6KFZ4
      Related
      ENSRNOP00000078582.2, ENSRNOT00000110815.2
      Conserved Domains (1) summary
      pfam05276
      Location:43 → 271
      SH3BP5; SH3 domain-binding protein 5 (SH3BP5)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      6589877..6676524 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094174.2 → XP_038950102.1  SH3 domain-binding protein 5 isoform X2

      Conserved Domains (1) summary
      pfam05276
      Location:1 → 143
      SH3BP5; SH3 domain-binding protein 5 (SH3BP5)

    2. XM_039094171.2 → XP_038950099.1  SH3 domain-binding protein 5 isoform X1

      UniProtKB/TrEMBL
      A0A8L2UQ41, A6KFZ3
      Related
      ENSRNOP00000071111.3, ENSRNOT00000082172.3
      Conserved Domains (1) summary
      pfam05276
      Location:43 → 302
      SH3BP5; SH3 domain-binding protein 5 (SH3BP5)

    3. XM_063275046.1 → XP_063131116.1  SH3 domain-binding protein 5 isoform X3

    4. XM_063275045.1 → XP_063131115.1  SH3 domain-binding protein 5 isoform X2

    5. XM_039094172.2 → XP_038950100.1  SH3 domain-binding protein 5 isoform X2

      Conserved Domains (1) summary
      pfam05276
      Location:1 → 143
      SH3BP5; SH3 domain-binding protein 5 (SH3BP5)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91Y80.2 GenPept UniProtKB/Swiss-Prot:Q91Y80

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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