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    S100a3 S100 calcium binding protein A3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114216, updated on 17-Aug-2024

    Summary

    Official Symbol
    S100a3provided by RGD
    Official Full Name
    S100 calcium binding protein A3provided by RGD
    Primary source
    RGD:620260
    See related
    EnsemblRapid:ENSRNOG00000012008 AllianceGenome:RGD:620260
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable calcium ion binding activity and calcium-dependent protein binding activity. Predicted to be located in Golgi apparatus; cytosol; and plasma membrane. Orthologous to human S100A3 (S100 calcium binding protein A3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 11.9), Spleen (RPKM 7.7) and 6 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See S100a3 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (178331856..178387280)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (176034283..176089702)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (189955619..189996029)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene S100 calcium binding protein A16 Neighboring gene U6 spliceosomal RNA Neighboring gene MIER family member 3, pseudogene 1 Neighboring gene S100 calcium binding protein A2 Neighboring gene S100 calcium-binding protein A4 Neighboring gene S100 calcium binding protein A5

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transition metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053681.1NP_446133.1  protein S100-A3

      See identical proteins and their annotated locations for NP_446133.1

      Status: PROVISIONAL

      Source sequence(s)
      AF140231
      UniProtKB/Swiss-Prot
      P62819
      UniProtKB/TrEMBL
      A0A8L2Q7T6, A6J6P6
      Conserved Domains (1) summary
      cd00213
      Location:490
      S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      178331856..178387280
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039101554.2XP_038957482.1  protein S100-A3 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K8A2, A0A8L2Q7T6, A6J6P3
      Conserved Domains (1) summary
      cd00213
      Location:1298
      S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...
    2. XM_008761122.4XP_008759344.1  protein S100-A3 isoform X2

      See identical proteins and their annotated locations for XP_008759344.1

      UniProtKB/TrEMBL
      A0A0G2K8A2, A0A8L2Q7T6, A6J6P3
      Conserved Domains (1) summary
      cd00213
      Location:1298
      S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...
    3. XM_006232559.5XP_006232621.1  protein S100-A3 isoform X3

      See identical proteins and their annotated locations for XP_006232621.1

      UniProtKB/Swiss-Prot
      P62819
      UniProtKB/TrEMBL
      A0A8L2Q7T6, A6J6P6
      Conserved Domains (1) summary
      cd00213
      Location:490
      S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...
    4. XM_017590578.3XP_017446067.1  protein S100-A3 isoform X3

      UniProtKB/Swiss-Prot
      P62819
      UniProtKB/TrEMBL
      A0A8L2Q7T6, A6J6P6
      Conserved Domains (1) summary
      cd00213
      Location:490
      S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...
    5. XM_017590577.3XP_017446066.1  protein S100-A3 isoform X3

      UniProtKB/Swiss-Prot
      P62819
      UniProtKB/TrEMBL
      A0A8L2Q7T6, A6J6P6
      Conserved Domains (1) summary
      cd00213
      Location:490
      S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...
    6. XM_006232560.5XP_006232622.1  protein S100-A3 isoform X3

      See identical proteins and their annotated locations for XP_006232622.1

      UniProtKB/Swiss-Prot
      P62819
      UniProtKB/TrEMBL
      A0A8L2Q7T6, A6J6P6
      Conserved Domains (1) summary
      cd00213
      Location:490
      S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...
    7. XM_006232558.5XP_006232620.1  protein S100-A3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A319, A0A8L2Q7T6
      Related
      ENSRNOP00000085336.1, ENSRNOT00000108343.2
      Conserved Domains (1) summary
      cd00213
      Location:16102
      S-100; S-100: S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 ...
    8. XM_017590580.3XP_017446069.1  protein S100-A3 isoform X3

      UniProtKB/Swiss-Prot
      P62819
      UniProtKB/TrEMBL
      A0A8L2Q7T6, A6J6P6
      Conserved Domains (1) summary
      cd00213
      Location:490
      S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...
    9. XM_006232563.5XP_006232625.1  protein S100-A3 isoform X3

      See identical proteins and their annotated locations for XP_006232625.1

      UniProtKB/Swiss-Prot
      P62819
      UniProtKB/TrEMBL
      A0A8L2Q7T6, A6J6P6
      Conserved Domains (1) summary
      cd00213
      Location:490
      S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...