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    Gucy2e guanylate cyclase 2E [ Rattus norvegicus (Norway rat) ]

    Gene ID: 113911, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Gucy2eprovided by RGD
    Official Full Name
    guanylate cyclase 2Eprovided by RGD
    Primary source
    RGD:69322
    See related
    EnsemblRapid:ENSRNOG00000015058 AllianceGenome:RGD:69322
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    GC-D; Gucy2d; ONE-GC; Gucy2ep
    Summary
    Enables guanylate cyclase activity and natriuretic peptide receptor activity. Involved in cGMP biosynthetic process and receptor guanylyl cyclase signaling pathway. Located in non-motile cilium and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 3.8), Muscle (RPKM 0.9) and 2 other tissues See more
    Orthologs
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    Genomic context

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    See Gucy2e in Genome Data Viewer
    Location:
    1q32
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (162150967..162185666)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (152739775..152774474)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (163398891..163433594)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134484906 Neighboring gene thioredoxin 1 like 1 Neighboring gene leucine rich repeat containing 32 Neighboring gene uncharacterized LOC134484907

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel calcium-regulated membrane guanylate cyclase transduction system in the olfactory neuroepithelium. Duda T, et al. Biochemistry, 2001 Oct 9. PMID 11580282
    2. A receptor guanylyl cyclase expressed specifically in olfactory sensory neurons. Fülle HJ, et al. Proc Natl Acad Sci U S A, 1995 Apr 11. PMID 7724600, Free PMC Article
    3. ONE-GC membrane guanylate cyclase, a trimodal odorant signal transducer. Duda T, et al. Biochem Biophys Res Commun, 2008 Mar 7. PMID 18178149
    4. Contribution of the receptor guanylyl cyclase GC-D to chemosensory function in the olfactory epithelium. Leinders-Zufall T, et al. Proc Natl Acad Sci U S A, 2007 Sep 4. PMID 17724338, Free PMC Article
    5. An olfactory subsystem that detects carbon disulfide and mediates food-related social learning. Munger SD, et al. Curr Biol, 2010 Aug 24. PMID 20637621, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate cyclase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables natriuretic peptide receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables odorant binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables odorant binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables olfactory receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables olfactory receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphorus-oxygen lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cGMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cGMP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cGMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in detection of carbon dioxide IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in detection of carbon dioxide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception of smell IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception of smell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in olfactory behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in olfactory learning IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in olfactory learning ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cGMP-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cGMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor guanylyl cyclase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in receptor guanylyl cyclase signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sensory perception of smell ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in ciliary membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in non-motile cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    guanylate cyclase 2D
    Names
    guanylate cyclase 2E, pseudogene
    guanylate cyclase, olfactory
    olfactory guanylyl cyclase GC-D
    NP_570093.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130737.5 → NP_570093.2  guanylate cyclase 2D precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      F1M245, P51839
      UniProtKB/TrEMBL
      A0A8L2QA99, A6I6D7
      Related
      ENSRNOP00000020513.7, ENSRNOT00000020513.8
      Conserved Domains (3) summary
      smart00044
      Location:861 → 1050
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14043
      Location:554 → 824
      PK_GC-2D; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-2D
      cd06371
      Location:71 → 445
      PBP1_sensory_GC_DEF-like; ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      162150967..162185666
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51839.2 GenPept UniProtKB/Swiss-Prot:P51839

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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