Abcg1 ATP binding cassette subfamily G member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Abcg1provided by MGI
Official Full Name: ATP binding cassette subfamily G member 1provided by MGI
Primary source: MGI:MGI:107704
See related: Ensembl:ENSMUSG00000024030 AllianceGenome:MGI:107704
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Abc8; White
Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The human protein is involved in macrophage cholesterol efflux and may regulate cellular lipid homeostasis in other cell types. [provided by RefSeq, Jul 2008]
Expression: Broad expression in thymus adult (RPKM 31.5), lung adult (RPKM 23.3) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 15.8 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (31276668..31336958)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (31057694..31117984)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Adrenal Abcg1 Controls Cholesterol Flux and Steroidogenesis.
Title: Adrenal Abcg1 Controls Cholesterol Flux and Steroidogenesis.
Macrophage Gpx4 deficiency aggravates foam cell formation by regulating the expression of scavenger receptors, ABCA1, and ABCG1.
Title: Macrophage Gpx4 deficiency aggravates foam cell formation by regulating the expression of scavenger receptors, ABCA1, and ABCG1.
Brain-specific loss of Abcg1 disturbs cholesterol metabolism and aggravates pyroptosis and neurological deficits after traumatic brain injury.
Title: Brain-specific loss of Abcg1 disturbs cholesterol metabolism and aggravates pyroptosis and neurological deficits after traumatic brain injury.
Interferon-gamma decreases ATP-binding cassette subfamily G member 1-mediated cholesterol efflux through small ubiquitin-like modifier/ubiquitin-dependent liver X receptor-alpha degradation in macrophages.
Title: Interferon-γ decreases ATP-binding cassette subfamily G member 1-mediated cholesterol efflux through small ubiquitin-like modifier/ubiquitin-dependent liver X receptor-α degradation in macrophages.
ATP-binding cassette g1 regulates osteogenesis via Wnt/beta-catenin and AMPK signaling pathways.
Title: ATP-binding cassette g1 regulates osteogenesis via Wnt/β-catenin and AMPK signaling pathways.
ABC transporters control ATP release through cholesterol-dependent volume-regulated anion channel activity.
Title: ABC transporters control ATP release through cholesterol-dependent volume-regulated anion channel activity.
Identification of Sca-1(+)Abcg1(+) bronchioalveolar epithelial cells as the origin of lung adenocarcinoma in Gprc5a-knockout mouse model through the interaction between lung progenitor AT2 and Lgr5 cells.
Title: Identification of Sca-1(+)Abcg1(+) bronchioalveolar epithelial cells as the origin of lung adenocarcinoma in Gprc5a-knockout mouse model through the interaction between lung progenitor AT2 and Lgr5 cells.
that the deficiency of alveolar macrophage ABCG1 promotes pulmonary granulomatous inflammation and that this is augmented by additional deletion of ABCA1
Title: Alveolar Macrophage ABCG1 Deficiency Promotes Pulmonary Granulomatous Inflammation.
Here, the authors study the contribution of lipid efflux in the retinal pigment epithelium by generating a mouse model lacking ABCA1 and its partner ABCG1 specifically in this layer. Mutant mice show lipid accumulation in the retinal pigment epithelium, reduced retinal pigment epithelium and retinal function, retinal inflammation and retinal pigment epithelium/photoreceptor degeneration.
Title: Impaired ABCA1/ABCG1-mediated lipid efflux in the mouse retinal pigment epithelium (RPE) leads to retinal degeneration.
ABCG1-overexpressing EPCs showed increased migration and tube formation and differentiation via the Lck/Yes-related novel protein tyrosine kinase /Akt/endothelial NO synthase pathway.
Title: Elevating ATP-binding cassette transporter G1 improves re-endothelialization function of endothelial progenitor cells via Lyn/Akt/eNOS in diabetic mice.

Submit: New GeneRIF Correction See all GeneRIFs (108)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:225284

Abcg1 (e-PCR), detects polymorphism
- UniSTS:234010

173G10-Sp6 (e-PCR), detects polymorphism
- UniSTS:140896

D1S3690 (e-PCR)
- UniSTS:474268

Abcg1 (e-PCR), detects polymorphism
- UniSTS:140995

Abcg1 (e-PCR), detects polymorphism
- UniSTS:259031

U34920 (e-PCR)
- UniSTS:186096

Abcg1 (e-PCR), detects polymorphism
- UniSTS:259580

AW413978 (e-PCR)
- UniSTS:180990

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ABC-type sterol transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ABC-type sterol transporter activity	IEA Inferred from Electronic Annotation more info
enables ABC-type sterol transporter activity	ISO Inferred from Sequence Orthology more info
enables ADP binding	IEA Inferred from Electronic Annotation more info
enables ADP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables cholesterol transfer activity	IEA Inferred from Electronic Annotation more info
enables cholesterol transfer activity	ISO Inferred from Sequence Orthology more info
enables floppase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylcholine floppase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylcholine floppase activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables toxin transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables toxin transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in amyloid precursor protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in amyloid precursor protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in cellular response to high density lipoprotein particle stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cholesterol efflux	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol efflux	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in cholesterol efflux	ISS Inferred from Sequence or Structural Similarity more info
involved_in cholesterol homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol homeostasis	IEA Inferred from Electronic Annotation more info
involved_in cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cholesterol transport	IDA Inferred from Direct Assay more info	PubMed
involved_in glycoprotein transport	IEA Inferred from Electronic Annotation more info
involved_in glycoprotein transport	ISO Inferred from Sequence Orthology more info
involved_in high-density lipoprotein particle remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular cholesterol transport	IEA Inferred from Electronic Annotation more info
involved_in intracellular cholesterol transport	ISO Inferred from Sequence Orthology more info
involved_in lipid translocation	IEA Inferred from Electronic Annotation more info
involved_in low-density lipoprotein particle remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of macrophage derived foam cell differentiation	IC Inferred by Curator more info	PubMed
involved_in phospholipid efflux	IEA Inferred from Electronic Annotation more info
involved_in phospholipid efflux	ISO Inferred from Sequence Orthology more info
involved_in phospholipid homeostasis	IEA Inferred from Electronic Annotation more info
involved_in phospholipid homeostasis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of amyloid-beta formation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of amyloid-beta formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cholesterol biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cholesterol efflux	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of secretory granule organization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of secretory granule organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of cholesterol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to lipid	IEA Inferred from Electronic Annotation more info
involved_in response to lipid	ISO Inferred from Sequence Orthology more info
involved_in reverse cholesterol transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ATP-binding cassette sub-family G member 1

Names: ATP-binding cassette 8; ATP-binding cassette transporter 8; ATP-binding cassette, sub-family G (WHITE), member 1; white protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.