Igl immunoglobulin lambda chain complex [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Iglprovided by MGI
Official Full Name: immunoglobulin lambda chain complexprovided by MGI
Primary source: MGI:MGI:96526
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Igl-x
Summary: Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. There are two classes of light chains, kappa and lambda. This region represents the germline organization of the lambda light chain locus from the C57BL/6J inbred mouse strain. The locus includes V (variable), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single V segment with a J segment; the C segment is later joined by splicing at the RNA level. This locus has four J-C clusters and three V segments that constitute two transcriptional units. One of the J-C clusters is incapable of encoding a protein; the J and C gene segments in this cluster are considered pseudogenes. Inbred strains of laboratory mice lack an additional J-C cluster of pseudogenes and several additional V segments that are found in wild mice. [provided by RefSeq, Jul 2008]
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Genomic context

Location:: 16 A3; 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (18845608..19079594, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (19026858..19260844, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

2 state-4 regions distal to the VlambdaJlambda cassettes are highly conserved . These regions may represent shadow enhancers, which are suspected to serve as booster or redundancy elements for the regulation of many genes.
Title: Targeted chromatin profiling reveals novel enhancers in Ig H and Ig L chain Loci.
Systematic deletion of known individual hypersensitive sites showed that HS1, which forms the major part of the transcription enhancer, Elambda3-1, is essential for Iglambda recombination and that it also helps to restrict Iglambda stage-specific recombination.
Title: The Eλ(3-1) enhancer is essential for V(D)J recombination of the murine immunoglobulin lambda light chain locus.
A kappa recombination signal sequence and its flanks support six- to nine-fold higher levels of recombination than a lambda counterpart.
Title: The recombination difference between mouse kappa and lambda segments is mediated by a pair-wise regulation mechanism.
Immunoglobulin lambda chain deficiency allows heavy (H) chain retention in the cytoplasm, but prevents H chain release from the cell, and as a result secondary lymphoid organs are B cell depleted while T cell levels remain normal.
Title: Block in development at the pre-B-II to immature B cell stage in mice without Ig kappa and Ig lambda light chain.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (5) 1 citation

General gene information

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Markers

AI528645 (e-PCR)
- UniSTS:209178

AU021880 (e-PCR)
- UniSTS:209179

M94351 (e-PCR)
- UniSTS:125002

AI662175 (e-PCR)
- UniSTS:165983

AW494620 (e-PCR)
- UniSTS:180875

NoName (e-PCR)
- UniSTS:237459

General protein information

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Names: immunoglobulin lambda chain complex

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.