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    PRSS23 serine protease 23 [ Homo sapiens (human) ]

    Gene ID: 11098, updated on 2-Nov-2024

    Summary

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    Official Symbol
    PRSS23provided by HGNC
    Official Full Name
    serine protease 23provided by HGNC
    Primary source
    HGNC:HGNC:14370
    See related
    Ensembl:ENSG00000150687 MIM:618376; AllianceGenome:HGNC:14370
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SIG13; SPUVE; ZSIG13
    Summary
    This gene encodes a conserved member of the trypsin family of serine proteases. Mouse studies found a decrease of mRNA levels of this gene after ovulation was induced. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
    Expression
    Ubiquitous expression in gall bladder (RPKM 19.0), urinary bladder (RPKM 17.9) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PRSS23 in Genome Data Viewer
    Location:
    11q14.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (86791071..86952910)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (86731821..86893752)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (86502113..86663952)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:86153050-86154249 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:86158730-86158943 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:86171015-86171543 Neighboring gene Sharpr-MPRA regulatory region 11231 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:86208417-86209018 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:86209019-86209620 Neighboring gene MPRA-validated peak1375 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3827 Neighboring gene malic enzyme 3 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:86234525-86235724 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:86270243-86270744 Neighboring gene MPRA-validated peak1376 silencer Neighboring gene Sharpr-MPRA regulatory region 6909 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_21738 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:86451485-86452099 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:86452100-86452713 Neighboring gene uncharacterized LOC102724775 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_21766 Neighboring gene NANOG hESC enhancer GRCh37_chr11:86522581-86523167 Neighboring gene Sharpr-MPRA regulatory region 1521 Neighboring gene MPRA-validated peak1379 silencer Neighboring gene MOB4 pseudogene 2 Neighboring gene olfactory receptor family 7 subfamily E member 13 pseudogene Neighboring gene MPRA-validated peak1380 silencer Neighboring gene PRSS23 antisense RNA 1 Neighboring gene olfactory receptor family 7 subfamily E member 2 pseudogene Neighboring gene Sharpr-MPRA regulatory region 12486 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:86651451-86651950 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3828 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3829 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3830 Neighboring gene FZD4 divergent transcript Neighboring gene frizzled class receptor 4 Neighboring gene uncharacterized LOC105369422 Neighboring gene heterogeneous nuclear ribonucleoprotein C pseudogene 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. PRSS23 knockdown inhibits gastric tumorigenesis through EIF2 signaling. Han B, et al. Pharmacol Res, 2019 Apr. PMID 30769097
    2. Serine protease PRSS23 is upregulated by estrogen receptor α and associated with proliferation of breast cancer cells. Chan HS, et al. PLoS One, 2012. PMID 22291950, Free PMC Article
    3. Identification of human epididymis protein-4 as a fibroblast-derived mediator of fibrosis. LeBleu VS, et al. Nat Med, 2013 Feb. PMID 23353556, Free PMC Article
    4. Exosomal microRNA-1246 from human umbilical cord mesenchymal stem cells potentiates myocardial angiogenesis in chronic heart failure. Wang Z, et al. Cell Biol Int, 2021 Nov. PMID 34270841
    5. Serine protease PRSS23 drives gastric cancer by enhancing tumor associated macrophage infiltration via FGF2. Qin S, et al. Front Immunol, 2022. PMID 36189305, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Serine protease PRSS23 drives gastric cancer by enhancing tumor associated macrophage infiltration via FGF2.
      Title: Serine protease PRSS23 drives gastric cancer by enhancing tumor associated macrophage infiltration via FGF2.
    2. Exosomal microRNA-1246 from human umbilical cord mesenchymal stem cells potentiates myocardial angiogenesis in chronic heart failure.
      Title: Exosomal microRNA-1246 from human umbilical cord mesenchymal stem cells potentiates myocardial angiogenesis in chronic heart failure.
    3. PRSS23 knockdown could suppress tumor growth of gastric cancer in vitro and in vivo through inhibiting EIF2 signaling, and EIF4E maybe a potential target of PRSS23. PRSS23 could serve as a potential target for gastric cancer therapy, and also a biomarker for the prediction of prognosis of gastric cancer.
      Title: PRSS23 knockdown inhibits gastric tumorigenesis through EIF2 signaling.
    4. PRSS23 might be a critical component of estrogen-mediated cell proliferation of ERalpha-positive breast cancer cells.
      Title: Serine protease PRSS23 is upregulated by estrogen receptor α and associated with proliferation of breast cancer cells.
    5. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC5107, DKFZp451O043

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    serine protease 23
    Names
    protease, serine 23
    putative secreted protein Zsig13
    serine protease, umbilical endothelium
    NP_001280108.1
    NP_001280109.1
    NP_009104.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001293179.2 → NP_001280108.1  serine protease 23 precursor

      See identical proteins and their annotated locations for NP_001280108.1

      Status: REVIEWED

      Source sequence(s)
      AP000654, BP206707
      Consensus CDS
      CCDS8278.1
      UniProtKB/Swiss-Prot
      B2RDJ1, B4E2J3, O95084, Q6IBI0
      UniProtKB/TrEMBL
      B3KQQ9
      Conserved Domains (1) summary
      cl21584
      Location:147 → 255
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. NM_001293180.2 → NP_001280109.1  serine protease 23 precursor

      See identical proteins and their annotated locations for NP_001280109.1

      Status: REVIEWED

      Source sequence(s)
      AP000654, DA895063
      Consensus CDS
      CCDS8278.1
      UniProtKB/Swiss-Prot
      B2RDJ1, B4E2J3, O95084, Q6IBI0
      UniProtKB/TrEMBL
      B3KQQ9
      Conserved Domains (1) summary
      cl21584
      Location:147 → 255
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    3. NM_007173.6 → NP_009104.3  serine protease 23 precursor

      Status: REVIEWED

      Source sequence(s)
      AP000654, DA910788
      UniProtKB/Swiss-Prot
      B2RDJ1, B4E2J3, O95084, Q6IBI0
      UniProtKB/TrEMBL
      B3KQQ9
      Related
      ENSP00000280258.4, ENST00000280258.6
      Conserved Domains (1) summary
      cl21584
      Location:147 → 255
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RNA

    1. NR_120591.3 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an exon and contains four alternate 3' exons, compared to variant 1. This variant is represented as non-coding because its lacks the ORF found in variant 1.
      Source sequence(s)
      BC063022, BU634437, CX871294
      Related
      ENST00000532234.5

    2. NR_120592.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an exon and contains two alternate 3' exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AP000654, AP001528
      Related
      ENST00000533902.2

    3. NR_120593.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks an exon and contains two alternate 3' exons, compared to variant 1. This variant is represented as non-coding because it lacks the ORF found in variant 1.
      Source sequence(s)
      AP001528, CX871294, DA600625

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      86791071..86952910
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      86731821..86893752
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001293178.1: Suppressed sequence

      Description
      NM_001293178.1: This RefSeq was removed because currently there is insufficient support for the transcript and protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95084.1 GenPept UniProtKB/Swiss-Prot:O95084

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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