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    Tsp1 tumor suppressor region 1 [ Mus musculus (house mouse) ]

    Gene ID: 108314, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Tsp1provided by MGI
    Official Full Name
    tumor suppressor region 1provided by MGI
    Primary source
    MGI:MGI:106195
    Gene type
    other
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MTS
    Annotation information
    not in current annotation release
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    Genomic context

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    Location:
    chromosome: 4

    Bibliography

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    Related articles in PubMed

    1. Thrombospondin-1 is a putative target gene of Runx2 and Runx3. Shi X, et al. Int J Mol Sci, 2013 Jul 10. PMID 23846726, Free PMC Article
    2. Fasciola hepatica Fatty Acid Binding Protein 1 Modulates T cell Polarization by Promoting Dendritic Cell Thrombospondin-1 Secretion Without Affecting Metabolic Homeostasis in Obese Mice. Zawistowska-Deniziak A, et al. Front Immunol, 2022. PMID 35720355, Free PMC Article
    3. A TMT-based shotgun proteomics uncovers overexpression of thrombospondin 1 as a contributor in pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome. Wang W, et al. Arch Toxicol, 2022 Jul. PMID 35357534, Free PMC Article
    4. Thrombospondin 1 Modulates Monocyte Properties to Suppress Intestinal Mucosal Inflammation. Fang LL, et al. J Innate Immun, 2015. PMID 25998580, Free PMC Article
    5. Thrombospondin-1 Is Necessary for the Development and Repair of Corneal Nerves. Tatematsu Y, et al. Int J Mol Sci, 2018 Oct 16. PMID 30332778, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Thrombospondin-1 promotes liver fibrosis by enhancing TGF-beta action in hepatic stellate cells.
      Title: Thrombospondin-1 promotes liver fibrosis by enhancing TGF-β action in hepatic stellate cells.
    2. SYNJ1 rescues motor functions in hereditary and sporadic Parkinson's disease mice by upregulating TSP-1 expression.
      Title: SYNJ1 rescues motor functions in hereditary and sporadic Parkinson's disease mice by upregulating TSP-1 expression.
    3. The endocytic receptor uPARAP is a regulator of extracellular thrombospondin-1.
      Title: The endocytic receptor uPARAP is a regulator of extracellular thrombospondin-1.
    4. Fasciola hepatica Fatty Acid Binding Protein 1 Modulates T cell Polarization by Promoting Dendritic Cell Thrombospondin-1 Secretion Without Affecting Metabolic Homeostasis in Obese Mice.
      Title: Fasciola hepatica Fatty Acid Binding Protein 1 Modulates T cell Polarization by Promoting Dendritic Cell Thrombospondin-1 Secretion Without Affecting Metabolic Homeostasis in Obese Mice.
    5. A TMT-based shotgun proteomics uncovers overexpression of thrombospondin 1 as a contributor in pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome.
      Title: A TMT-based shotgun proteomics uncovers overexpression of thrombospondin 1 as a contributor in pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome.
    6. Inhibition of thrombospondin-1 reduces glutathione activity and worsens acute liver injury during acetaminophen hepatotoxicity in mice.
      Title: Inhibition of thrombospondin-1 reduces glutathione activity and worsens acute liver injury during acetaminophen hepatotoxicity in mice.
    7. Blocking thrombospondin-1 signaling via CD47 mitigates renal interstitial fibrosis.
      Title: Blocking thrombospondin-1 signaling via CD47 mitigates renal interstitial fibrosis.
    8. TSP1 ameliorates age-related macular degeneration by regulating the STAT3-iNOS signaling pathway.
      Title: TSP1 ameliorates age-related macular degeneration by regulating the STAT3-iNOS signaling pathway.
    9. that TSP1-CD47 signaling may stimulate vascularized allograft rejection
      Title: Elimination of donor CD47 protects against vascularized allograft rejection in mice.
    10. Changes in the expression of TSP-1 were identified in the brain of an autistic-like mouse strain.
      Title: Alterations in neuronal cytoskeletal and astrocytic proteins content in the brain of the autistic-like mouse strain C58/J.
    Submit: New GeneRIF Correction See all GeneRIFs (35)

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