Abhd3 abhydrolase domain containing 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Abhd3provided by MGI
Official Full Name: abhydrolase domain containing 3provided by MGI
Primary source: MGI:MGI:2147183
See related: Ensembl:ENSMUSG00000002475 AllianceGenome:MGI:2147183
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: LABH3
Summary: Predicted to enable carboxylic ester hydrolase activity. Involved in phosphatidylcholine metabolic process. Predicted to be located in membrane. Is expressed in several structures, including brain; genitourinary system; liver; olfactory epithelium; and spleen. Orthologous to human ABHD3 (abhydrolase domain containing 3, phospholipase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in cerebellum adult (RPKM 12.2), liver adult (RPKM 11.7) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 A1; 18 5.28 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (10644411..10706784, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (10644411..10706783, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study descrbed a cell-based screen for enzyme substrate discovery and its application to identify the protein alpha/beta-hydrolase domain-containing 3 as a lipase that selectively cleaves medium-chain and oxidatively truncated phospholipids.
Title: Metabolomics annotates ABHD3 as a physiologic regulator of medium-chain phospholipids.
a member of a novel family of membrane bound enzymes whose function has yet to be determined; highest expression level in the liver [LABH3]
Title: Cloning and tissue distribution of three murine alpha/beta hydrolase fold protein cDNAs.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

RH125606 (e-PCR)
- UniSTS:162420

Abhd3 (e-PCR), detects polymorphism
- UniSTS:265210

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acetylesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables monoacylglycerol lipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylserine 1-acylhydrolase activity	IEA Inferred from Electronic Annotation more info
enables phospholipase A1 activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase A1 activity	IEA Inferred from Electronic Annotation more info
enables phospholipase A1 activity	ISO Inferred from Sequence Orthology more info
enables phospholipase A1 activity	ISS Inferred from Sequence or Structural Similarity more info
enables phospholipase A2 activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
enables phospholipase A2 activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in medium-chain fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in medium-chain fatty acid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylcholine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylcholine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylcholine metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phospholipase ABHD3

Names: abhydrolase domain-containing protein 3; lung alpha/beta hydrolase 3; mmLABH3

NP_598891.1

EC 3.1.1.32

EC 3.1.1.4

XP_011245095.1

EC 3.1.1.32

EC 3.1.1.4

XP_011245096.1

EC 3.1.1.32

EC 3.1.1.4

XP_036016808.1

EC 3.1.1.32

EC 3.1.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_134130.1 → NP_598891.1 phospholipase ABHD3

See identical proteins and their annotated locations for NP_598891.1

Status: VALIDATED

Source sequence(s)

AF429302

Consensus CDS

CCDS29057.1

UniProtKB/Swiss-Prot

Q3UNF7, Q91ZH7

UniProtKB/TrEMBL

A0A452J888

Related

ENSMUSP00000113137.3, ENSMUST00000117828.9

Conserved Domains (2) summary

PLN02511
Location:39 → 403

PLN02511; hydrolase

cl21494
Location:92 → 398

Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

10644411..10706784 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036160915.1 → XP_036016808.1 phospholipase ABHD3 isoform X1

Conserved Domains (1) summary

PLN02511
Location:18 → 311

PLN02511; hydrolase
XM_011246793.3 → XP_011245095.1 phospholipase ABHD3 isoform X2

Conserved Domains (1) summary

PLN02511
Location:39 → 223

PLN02511; hydrolase
XM_011246794.3 → XP_011245096.1 phospholipase ABHD3 isoform X3

Conserved Domains (1) summary

PLN02511
Location:39 → 190

PLN02511; hydrolase