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    Slc9a3 solute carrier family 9 (sodium/hydrogen exchanger), member 3 [ Mus musculus (house mouse) ]

    Gene ID: 105243, updated on 2-Nov-2024

    Summary

    Official Symbol
    Slc9a3provided by MGI
    Official Full Name
    solute carrier family 9 (sodium/hydrogen exchanger), member 3provided by MGI
    Primary source
    MGI:MGI:105064
    See related
    Ensembl:ENSMUSG00000036123 AllianceGenome:MGI:105064
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NHE3; NHE-3; 9030624O13Rik
    Summary
    Enables PDZ domain binding activity and sodium:proton antiporter activity. Acts upstream of or within regulation of pH and sodium ion transport. Located in apical plasma membrane; brush border membrane; and vesicle. Is expressed in early conceptus; liver; metanephros; and oocyte. Human ortholog(s) of this gene implicated in congenital secretory sodium diarrhea 8. Orthologous to human SLC9A3 (solute carrier family 9 member A3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in colon adult (RPKM 52.1), small intestine adult (RPKM 51.8) and 4 other tissues See more
    Orthologs
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    Genomic context

    See Slc9a3 in Genome Data Viewer
    Location:
    13 C1; 13 40.15 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (74234374..74317561)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (74086255..74169442)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene tubulin polymerization promoting protein Neighboring gene integrin linked kinase pseudogene Neighboring gene centrosomal protein 72 Neighboring gene predicted gene, 41003 Neighboring gene exocyst complex component 3 Neighboring gene STARR-positive B cell enhancer ABC_E8534 Neighboring gene aryl-hydrocarbon receptor repressor

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (10)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables PDZ domain binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables potassium:proton antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sodium:proton antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sodium:proton antiporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sodium:proton antiporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of intracellular pH IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of intracellular pH ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of pH IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of pH ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sodium ion import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion import across plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within sodium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in brush border ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in brush border membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in brush border membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in brush border membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in recycling endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in recycling endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    sodium/hydrogen exchanger 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081060.3NP_001074529.1  sodium/hydrogen exchanger 3 precursor

      See identical proteins and their annotated locations for NP_001074529.1

      Status: VALIDATED

      Source sequence(s)
      AC154839
      Consensus CDS
      CCDS36731.1
      UniProtKB/Swiss-Prot
      G3X939, Q8BZU0
      UniProtKB/TrEMBL
      A0A286YD40
      Related
      ENSMUSP00000038142.7, ENSMUST00000036208.7
      Conserved Domains (1) summary
      TIGR00840
      Location:43642
      b_cpa1; sodium/hydrogen exchanger 3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      74234374..74317561
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517021.4XP_006517084.1  sodium/hydrogen exchanger 3 isoform X1

      UniProtKB/TrEMBL
      A0A286YD40
      Conserved Domains (1) summary
      TIGR00840
      Location:52650
      b_cpa1; sodium/hydrogen exchanger 3
    2. XM_006517022.5XP_006517085.1  sodium/hydrogen exchanger 3 isoform X2

      See identical proteins and their annotated locations for XP_006517085.1

      UniProtKB/Swiss-Prot
      G3X939, Q8BZU0
      UniProtKB/TrEMBL
      A0A286YD40
      Related
      ENSMUSP00000152682.2, ENSMUST00000221703.2
      Conserved Domains (1) summary
      TIGR00840
      Location:43642
      b_cpa1; sodium/hydrogen exchanger 3