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    TRAIP TRAF interacting protein [ Homo sapiens (human) ]

    Gene ID: 10293, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TRAIPprovided by HGNC
    Official Full Name
    TRAF interacting proteinprovided by HGNC
    Primary source
    HGNC:HGNC:30764
    See related
    Ensembl:ENSG00000183763 MIM:605958; AllianceGenome:HGNC:30764
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TRIP; SCKL9; RNF206
    Summary
    This gene encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit 1 activation that is required for cell activation and protection against apoptosis. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in testis (RPKM 4.0), bone marrow (RPKM 2.3) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TRAIP in Genome Data Viewer
    Location:
    3p21.31
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (49828601..49856564, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (49858496..49886461, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (49866034..49893997, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14375 Neighboring gene Sharpr-MPRA regulatory region 10954 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19876 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:49844839-49845735 Neighboring gene inka box actin regulator 1 Neighboring gene microRNA 5193 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:49848893-49849392 Neighboring gene ubiquitin like modifier activating enzyme 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19880 Neighboring gene CaM kinase like vesicle associated Neighboring gene RNA, 7SL, cytoplasmic 217, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:49905159-49906091 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:49906092-49907023 Neighboring gene actin like 11, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. TRAIP resolves DNA replication-transcription conflicts during the S-phase of unperturbed cells. Scaramuzza S, et al. Nat Commun, 2023 Aug 21. PMID 37604812, Free PMC Article
    2. The TRAF-interacting protein (TRIP) is a regulator of keratinocyte proliferation. Almeida S, et al. J Invest Dermatol, 2011 Feb. PMID 21068752
    3. TRAIP is a regulator of the spindle assembly checkpoint. Chapard C, et al. J Cell Sci, 2014 Dec 15. PMID 25335891
    4. Dimerization of TRAF-interacting protein (TRAIP) regulates the mitotic progression. Park IS, et al. Biochem Biophys Res Commun, 2015 Aug 7. PMID 26093298
    5. TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism. Harley ME, et al. Nat Genet, 2016 Jan. PMID 26595769, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TRAIP suppressed apoptosis and cell cycle to promote prostate cancer proliferation via TRAF2-PI3K-AKT pathway activation.
      Title: TRAIP suppressed apoptosis and cell cycle to promote prostate cancer proliferation via TRAF2-PI3K-AKT pathway activation.
    2. TRAIP resolves DNA replication-transcription conflicts during the S-phase of unperturbed cells.
      Title: TRAIP resolves DNA replication-transcription conflicts during the S-phase of unperturbed cells.
    3. ZNF212 promotes genomic integrity through direct interaction with TRAIP.
      Title: ZNF212 promotes genomic integrity through direct interaction with TRAIP.
    4. Silencing TRAIP suppresses cell proliferation and migration/invasion of triple negative breast cancer via RB-E2F signaling and EMT.
      Title: Silencing TRAIP suppresses cell proliferation and migration/invasion of triple negative breast cancer via RB-E2F signaling and EMT.
    5. TRAIP modulates the IGFBP3/AKT pathway to enhance the invasion and proliferation of osteosarcoma by promoting KANK1 degradation.
      Title: TRAIP modulates the IGFBP3/AKT pathway to enhance the invasion and proliferation of osteosarcoma by promoting KANK1 degradation.
    6. The Ubiquitin Ligase TRAIP: Double-Edged Sword at the Replisome.
      Title: The Ubiquitin Ligase TRAIP: Double-Edged Sword at the Replisome.
    7. TRIP suppresses cell proliferation and invasion in choroidal melanoma via promoting the proteasomal degradation of Twist1.
      Title: TRIP suppresses cell proliferation and invasion in choroidal melanoma via promoting the proteasomal degradation of Twist1.
    8. TRAIP promotes malignant behaviors and correlates with poor prognosis in liver cancer.
      Title: TRAIP promotes malignant behaviors and correlates with poor prognosis in liver cancer.
    9. TRAIP is important for the recruitment of NEIL3 but not FANCD2, and knockdown of TRAIP promotes FA/BRCA pathway activation. Interestingly, TRAIP is non-epistatic with both NEIL3 and FA pathways in psoralen-ICL repair, suggesting that TRAIP may function upstream of the two pathways.
      Title: Cooperation of the NEIL3 and Fanconi anemia/BRCA pathways in interstrand crosslink repair.
    10. present results, together with other recent findings, establish TRAIP as a master regulator of DNA helicase CMG unloading and the response of the replisome to obstacles
      Title: TRAIP is a master regulator of DNA interstrand crosslink repair.
    Submit: New GeneRIF Correction See all GeneRIFs (28)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Seckel syndrome 9
    MedGen: C4225212 OMIM: 616777 GeneReviews: Not available
    		Compare labs

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within apoptotic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of interferon-beta production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of tumor necrosis factor-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein-DNA covalent cross-linking repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in replication fork processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in replication fork processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in replication fork processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in site of DNA damage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in site of DNA damage IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase TRAIP
    Names
    RING-type E3 ubiquitin transferase TRAIP
    ring finger protein 206
    NP_005870.2
    XP_016861015.1
    XP_047303196.1
    XP_054200892.1
    XP_054200893.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_046695.1 RefSeqGene

      Range
      4996..32959
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_005879.3 → NP_005870.2  E3 ubiquitin-protein ligase TRAIP

      See identical proteins and their annotated locations for NP_005870.2

      Status: REVIEWED

      Source sequence(s)
      AC139451, BC019283, BQ446539, BX473682
      Consensus CDS
      CCDS2806.1
      UniProtKB/Swiss-Prot
      B5BU84, B5BUL3, O00467, Q9BWF2
      UniProtKB/TrEMBL
      A8K807
      Related
      ENSP00000328203.2, ENST00000331456.7
      Conserved Domains (2) summary
      cd16480
      Location:6 → 50
      RING-H2_TRAIP; RING finger, H2 subclass, found in TRAF-interacting protein (TRAIP) and similar proteins
      cl25732
      Location:68 → 279
      SMC_N; RecF/RecN/SMC N terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      49828601..49856564 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017005526.2 → XP_016861015.1  E3 ubiquitin-protein ligase TRAIP isoform X1

    2. XM_047447240.1 → XP_047303196.1  E3 ubiquitin-protein ligase TRAIP isoform X2

    RNA

    1. XR_007094382.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      49858496..49886461 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344917.1 → XP_054200892.1  E3 ubiquitin-protein ligase TRAIP isoform X1

    2. XM_054344918.1 → XP_054200893.1  E3 ubiquitin-protein ligase TRAIP isoform X2

    RNA

    1. XR_008486627.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BWF2.1 GenPept UniProtKB/Swiss-Prot:Q9BWF2

    Gene LinkOut

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