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    TPTEP2-CSNK1E TPTEP2-CSNK1E readthrough [ Homo sapiens (human) ]

    Gene ID: 102800317, updated on 17-Aug-2024

    Summary

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    Official Symbol
    TPTEP2-CSNK1Eprovided by HGNC
    Official Full Name
    TPTEP2-CSNK1E readthroughprovided by HGNC
    Primary source
    HGNC:HGNC:53829
    See related
    Ensembl:ENSG00000283900 AllianceGenome:HGNC:53829
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LOC400927-CSNK1E
    Summary
    This locus represents naturally occurring readthrough transcription between the neighboring LOC400927 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene) and CSNK1E (casein kinase I isoform epsilon) genes on chromosome 22. The readthrough transcript encodes the same protein as the downstream gene product (casein kinase I isoform epsilon). [provided by RefSeq, Feb 2014]
    Expression
    Ubiquitous expression in endometrium (RPKM 31.3), brain (RPKM 31.3) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See TPTEP2-CSNK1E in Genome Data Viewer
    Location:
    22q13.1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (38290691..38398915, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (38754994..38863179, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (38686697..38794920, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38620666-38621166 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38624990-38625720 Neighboring gene transmembrane protein 184B Neighboring gene TMEM184B antisense RNA 1 Neighboring gene small nucleolar RNA, H/ACA box 92 Neighboring gene RNA, 7SL, cytoplasmic 704, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13713 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19001 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19002 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38659892-38660392 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr22:38667767-38668476 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13714 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38679509-38680035 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38685261-38685970 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38685971-38686678 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr22:38694325-38695524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19003 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19004 Neighboring gene casein kinase 1 epsilon Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38706687-38707466 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19006 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19009 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19008 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19007 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13715 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38714878-38715782 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38718279-38719070 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:38720450-38720962 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr22:38720963-38721473 Neighboring gene Sharpr-MPRA regulatory region 8587 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38723521-38724032 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:38737560-38737744 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38740513-38741012 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38743105-38744002 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19010 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13716 Neighboring gene TPTE pseudogene 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:38793649-38794432 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13717 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38799517-38800018 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38800019-38800518 Neighboring gene uncharacterized LOC105373030 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13718 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38813561-38814060 Neighboring gene uncharacterized LOC101927183 Neighboring gene potassium inwardly rectifying channel subfamily J member 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Structural basis for the potent and selective inhibition of casein kinase 1 epsilon. Long AM, et al. J Med Chem, 2012 Nov 26. PMID 23106386
    2. Role of CK1 in GSK3beta-mediated phosphorylation and degradation of snail. Xu Y, et al. Oncogene, 2010 May 27. PMID 20305697
    3. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Daub H, et al. Mol Cell, 2008 Aug 8. PMID 18691976
    4. Large-scale proteomics analysis of the human kinome. Oppermann FS, et al. Mol Cell Proteomics, 2009 Jul. PMID 19369195, Free PMC Article
    5. Patterns of somatic mutation in human cancer genomes. Greenman C, et al. Nature, 2007 Mar 8. PMID 17344846, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CKI-epsilon is a potent TDP-43 kinase in vivo and in vitro.
      Title: TDP-43 Phosphorylation by casein kinase Iε promotes oligomerization and enhances toxicity in vivo.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • FLJ17345, FLJ34950

    General protein information

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    Preferred Names
    casein kinase I isoform epsilon
    Names
    CKI-epsilon
    LOC400927-CSNK1E readthrough
    NP_001276841.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289912.2 → NP_001276841.1  casein kinase I isoform epsilon

      See identical proteins and their annotated locations for NP_001276841.1

      Status: VALIDATED

      Source sequence(s)
      AK092269, AL020993, Z97056
      UniProtKB/Swiss-Prot
      P49674
      UniProtKB/TrEMBL
      Q53EZ1, Q5U045
      Related
      ENSP00000383067.2, ENST00000400206.7
      Conserved Domains (1) summary
      cd14125
      Location:8 → 282
      STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      38290691..38398915 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      38754994..38863179 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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