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    CYP3A4 cytochrome P450 family 3 subfamily A member 4 [ Macaca fascicularis (crab-eating macaque) ]

    Gene ID: 102144258, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CYP3A4
    Official Full Name
    cytochrome P450 family 3 subfamily A member 4
    Primary source
    VGNC:VGNC:83080
    See related
    Ensembl:ENSMFAG00000046026
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca fascicularis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    CYP3A8; CYPIIIA8
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    Genomic context

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    See CYP3A4 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_05 current T2T-MFA8v1.0 (GCF_037993035.1) 3 NC_088377.1 (48404721..48434923, complement)
    102 previous assembly MFA1912RKSv2 (GCF_012559485.2) 3 NC_052257.1 (166294233..166324425, complement)

    Chromosome 3 - NC_088377.1Genomic Context describing neighboring genes Neighboring gene zinc finger and SCAN domain containing 25 Neighboring gene cytochrome P450 family 3 subfamily A member 5 Neighboring gene uncharacterized LOC135969780 Neighboring gene uncharacterized LOC135969779 Neighboring gene cytochrome P450 family 3 subfamily A member 7 Neighboring gene ras-related protein R-Ras2-like Neighboring gene cytochrome P450 family 3 subfamily A member 43

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Purification and characterization of two forms of hepatic microsomal cytochrome P450 from untreated cynomolgus monkeys. Ohmori S, et al. Arch Biochem Biophys, 1993 Sep. PMID 8373178
    2. Purification of cytochrome P-450 from polychlorinated biphenyl-treated crab-eating monkeys: high homology to a form of human cytochrome P-450. Ohta K, et al. Biochim Biophys Acta, 1989 Jun 13. PMID 2500151
    3. Molecular cloning of monkey liver cytochrome P-450 cDNAs: similarity of the primary sequences to human cytochromes P-450. Komori M, et al. Biochim Biophys Acta, 1992 Dec 29. PMID 1282830
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables testosterone 6-beta-hydroxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in oxidative demethylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in steroid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytochrome P450 3A8
    Names
    Cytochrome P-450-MK2
    Cytochrome P450 3A8
    Cytochrome P450-MKNF2
    P-450 3A
    cytochrome P-450 3A
    XP_045245433.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_037993035.1-RS_2024_05

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference T2T-MFA8v1.0

    Genomic

    1. NC_088377.1 Reference T2T-MFA8v1.0

      Range
      48404721..48434923 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_045389498.2 → XP_045245433.2  cytochrome P450 3A8

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001284534.1: Suppressed sequence

      Description
      NM_001284534.1: This RefSeq record was removed as a result of standard genome annotation processing. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33268.1 GenPept UniProtKB/Swiss-Prot:P33268

    Gene LinkOut

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