Fbxl14 F-box and leucine-rich repeat protein 14 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fbxl14provided by MGI
Official Full Name: F-box and leucine-rich repeat protein 14provided by MGI
Primary source: MGI:MGI:2141676
See related: Ensembl:ENSMUSG00000030019 AllianceGenome:MGI:2141676
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fbx14l
Summary: Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to human FBXL14 (F-box and leucine rich repeat protein 14). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human all
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Genomic context

Location:: 6 F1; 6 56.86 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (119456629..119460847)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (119479668..119483886)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results suggest that SCF(FBXL14) promotes neuronal differentiation by targeting HES1 for ubiquitin-dependent proteolysis and that the C-terminal WRPW motif in HES1 is required for this process
Title: The E3 ubiquitin ligase SCF(FBXL14) complex stimulates neuronal differentiation by targeting the Notch signaling factor HES1 for proteolysis.
Data show that Twist1 small interfering RNA prevents hypoxia-induced Fbxl14 down-regulation and SNAIL1 stabilization.
Title: The hypoxia-controlled FBXL14 ubiquitin ligase targets SNAIL1 for proteasome degradation.

Submit: New GeneRIF Correction

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235536

RH133478 (e-PCR)
- UniSTS:216761

AW322056 (e-PCR)
- UniSTS:179450

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: F-box/LRR-repeat protein 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133940.3 → NP_598701.2 F-box/LRR-repeat protein 14

See identical proteins and their annotated locations for NP_598701.2

Status: VALIDATED

Source sequence(s)

AC126607

Consensus CDS

CCDS20475.1

UniProtKB/Swiss-Prot

Q3U2Q9, Q8BID8, Q8R5H7, Q8VDT7, Q922N5

Related

ENSMUSP00000032094.6, ENSMUST00000032094.7

Conserved Domains (3) summary

cd09293
Location:228 → 395

AMN1; Antagonist of mitotic exit network protein 1

sd00034
Location:145 → 170

LRR_AMN1; leucine-rich repeat [structural motif]

pfam12937
Location:5 → 46

F-box-like