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    TH tyrosine hydroxylase [ Ovis aries (sheep) ]

    Gene ID: 101120619, updated on 8-Mar-2024

    Summary

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    Gene symbol
    TH
    Gene description
    tyrosine hydroxylase
    See related
    EnsemblRapid:ENSOARG00020007423
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Ovis aries
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 21
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 21 NC_056074.1 (45764210..45770799)

    Chromosome 21 - NC_056074.1Genomic Context describing neighboring genes Neighboring gene collagen alpha-1(I) chain-like Neighboring gene achaete-scute family bHLH transcription factor 2 Neighboring gene tetraspanin 32 Neighboring gene insulin like growth factor 2 Neighboring gene insulin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_056074.1 Chromosome 21 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables tyrosine 3-monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dopamine biosynthetic process from tyrosine IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in heart development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tyrosine 3-monooxygenase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Genomic

    1. NC_056074.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

      Range
      45764210..45770799
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_027959751.2 → XP_027815552.1  tyrosine 3-monooxygenase

      UniProtKB/TrEMBL
      A0A6P7D9Y4
      Related
      ENSOARP00020009634.2, ENSOART00020011712.2
      Conserved Domains (3) summary
      pfam00351
      Location:159 → 488
      Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase
      pfam12549
      Location:2 → 26
      TOH_N; Tyrosine hydroxylase N terminal
      cl09141
      Location:38 → 150
      ACT; ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme
    Nucleotide Protein Strain
    Heading Accession and Version

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