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    GUCY2C guanylate cyclase 2C [ Felis catus (domestic cat) ]

    Gene ID: 101095109, updated on 17-Aug-2024

    Summary

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    Official Symbol
    GUCY2C
    Official Full Name
    guanylate cyclase 2C
    Primary source
    VGNC:VGNC:67516
    See related
    EnsemblRapid:ENSFCTG00005022079
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Felis catus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
    Orthologs
    human mouse all
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    Genomic context

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    See GUCY2C in Genome Data Viewer
    Location:
    chromosome: B4
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) B4 NC_058374.1 (48451387..48592323, complement)
    104 previous assembly Felis_catus_9.0 (GCF_000181335.3) B4 NC_018729.3 (50409200..50549462, complement)

    Chromosome B4 - NC_058374.1Genomic Context describing neighboring genes Neighboring gene phospholipase B domain containing 1 Neighboring gene uncharacterized LOC109501470 Neighboring gene uncharacterized LOC109501468 Neighboring gene H4 histone 16 Neighboring gene H2A.J histone

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables guanylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables peptide receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cGMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in receptor guanylyl cyclase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    heat-stable enterotoxin receptor
    Names
    guanylate cyclase 2C (heat stable enterotoxin receptor)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference F.catus_Fca126_mat1.0 Primary Assembly

    Genomic

    1. NC_058374.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

      Range
      48451387..48592323 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_045061416.1 → XP_044917351.1  heat-stable enterotoxin receptor isoform X1

      UniProtKB/TrEMBL
      A0A2I2U408
      Conserved Domains (3) summary
      smart00044
      Location:867 → 1058
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14044
      Location:559 → 829
      PK_GC-C; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-C
      cd06369
      Location:114 → 494
      PBP1_GC_C_enterotoxin_receptor; ligand-binding domain of the membrane guanylyl cyclase C

    2. XM_045061421.1 → XP_044917356.1  heat-stable enterotoxin receptor isoform X1

      UniProtKB/TrEMBL
      A0A2I2U408
      Conserved Domains (3) summary
      smart00044
      Location:867 → 1058
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14044
      Location:559 → 829
      PK_GC-C; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-C
      cd06369
      Location:114 → 494
      PBP1_GC_C_enterotoxin_receptor; ligand-binding domain of the membrane guanylyl cyclase C

    3. XM_045061419.1 → XP_044917354.1  heat-stable enterotoxin receptor isoform X1

      UniProtKB/TrEMBL
      A0A2I2U408
      Conserved Domains (3) summary
      smart00044
      Location:867 → 1058
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14044
      Location:559 → 829
      PK_GC-C; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-C
      cd06369
      Location:114 → 494
      PBP1_GC_C_enterotoxin_receptor; ligand-binding domain of the membrane guanylyl cyclase C

    4. XM_045061424.1 → XP_044917359.1  heat-stable enterotoxin receptor isoform X4

      UniProtKB/TrEMBL
      A0A2I2U408
      Conserved Domains (3) summary
      smart00044
      Location:782 → 973
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14044
      Location:474 → 744
      PK_GC-C; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-C
      cd06369
      Location:29 → 409
      PBP1_GC_C_enterotoxin_receptor; ligand-binding domain of the membrane guanylyl cyclase C

    5. XM_045061420.1 → XP_044917355.1  heat-stable enterotoxin receptor isoform X1

      UniProtKB/TrEMBL
      A0A2I2U408
      Conserved Domains (3) summary
      smart00044
      Location:867 → 1058
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14044
      Location:559 → 829
      PK_GC-C; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-C
      cd06369
      Location:114 → 494
      PBP1_GC_C_enterotoxin_receptor; ligand-binding domain of the membrane guanylyl cyclase C

    6. XM_045061425.1 → XP_044917360.1  heat-stable enterotoxin receptor isoform X5

      UniProtKB/TrEMBL
      A0A2I2U408
      Related
      ENSFCTP00005046769.1, ENSFCTT00005064414.1
      Conserved Domains (3) summary
      smart00044
      Location:727 → 918
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14044
      Location:419 → 689
      PK_GC-C; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-C
      cl10011
      Location:12 → 354
      Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

    7. XM_045061423.1 → XP_044917358.1  heat-stable enterotoxin receptor isoform X4

      UniProtKB/TrEMBL
      A0A2I2U408
      Related
      ENSFCTP00005046518.1, ENSFCTT00005063977.1
      Conserved Domains (3) summary
      smart00044
      Location:782 → 973
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14044
      Location:474 → 744
      PK_GC-C; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-C
      cd06369
      Location:29 → 409
      PBP1_GC_C_enterotoxin_receptor; ligand-binding domain of the membrane guanylyl cyclase C

    8. XM_045061412.1 → XP_044917347.1  heat-stable enterotoxin receptor isoform X1

      UniProtKB/TrEMBL
      A0A2I2U408
      Conserved Domains (3) summary
      smart00044
      Location:867 → 1058
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14044
      Location:559 → 829
      PK_GC-C; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-C
      cd06369
      Location:114 → 494
      PBP1_GC_C_enterotoxin_receptor; ligand-binding domain of the membrane guanylyl cyclase C

    9. XM_019834559.3 → XP_019690118.2  heat-stable enterotoxin receptor isoform X2

      UniProtKB/TrEMBL
      A0A2I2U408
      Related
      ENSFCTP00005046260.1, ENSFCTT00005063554.1
      Conserved Domains (3) summary
      smart00044
      Location:867 → 1058
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14044
      Location:559 → 829
      PK_GC-C; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-C
      cd06369
      Location:114 → 494
      PBP1_GC_C_enterotoxin_receptor; ligand-binding domain of the membrane guanylyl cyclase C

    10. XM_045061413.1 → XP_044917348.1  heat-stable enterotoxin receptor isoform X1

      UniProtKB/TrEMBL
      A0A2I2U408
      Conserved Domains (3) summary
      smart00044
      Location:867 → 1058
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14044
      Location:559 → 829
      PK_GC-C; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-C
      cd06369
      Location:114 → 494
      PBP1_GC_C_enterotoxin_receptor; ligand-binding domain of the membrane guanylyl cyclase C

    11. XM_045061414.1 → XP_044917349.1  heat-stable enterotoxin receptor isoform X1

      UniProtKB/TrEMBL
      A0A2I2U408
      Conserved Domains (3) summary
      smart00044
      Location:867 → 1058
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14044
      Location:559 → 829
      PK_GC-C; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-C
      cd06369
      Location:114 → 494
      PBP1_GC_C_enterotoxin_receptor; ligand-binding domain of the membrane guanylyl cyclase C

    12. XM_045061415.1 → XP_044917350.1  heat-stable enterotoxin receptor isoform X1

      UniProtKB/TrEMBL
      A0A2I2U408
      Conserved Domains (3) summary
      smart00044
      Location:867 → 1058
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14044
      Location:559 → 829
      PK_GC-C; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-C
      cd06369
      Location:114 → 494
      PBP1_GC_C_enterotoxin_receptor; ligand-binding domain of the membrane guanylyl cyclase C

    13. XM_045061417.1 → XP_044917352.1  heat-stable enterotoxin receptor isoform X1

      UniProtKB/TrEMBL
      A0A2I2U408
      Conserved Domains (3) summary
      smart00044
      Location:867 → 1058
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14044
      Location:559 → 829
      PK_GC-C; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-C
      cd06369
      Location:114 → 494
      PBP1_GC_C_enterotoxin_receptor; ligand-binding domain of the membrane guanylyl cyclase C

    14. XM_045061422.1 → XP_044917357.1  heat-stable enterotoxin receptor isoform X1

      UniProtKB/TrEMBL
      A0A2I2U408
      Conserved Domains (3) summary
      smart00044
      Location:867 → 1058
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14044
      Location:559 → 829
      PK_GC-C; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-C
      cd06369
      Location:114 → 494
      PBP1_GC_C_enterotoxin_receptor; ligand-binding domain of the membrane guanylyl cyclase C

    15. XM_045061418.1 → XP_044917353.1  heat-stable enterotoxin receptor isoform X1

      UniProtKB/TrEMBL
      A0A2I2U408
      Conserved Domains (3) summary
      smart00044
      Location:867 → 1058
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14044
      Location:559 → 829
      PK_GC-C; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-C
      cd06369
      Location:114 → 494
      PBP1_GC_C_enterotoxin_receptor; ligand-binding domain of the membrane guanylyl cyclase C

    16. XM_003988439.5 → XP_003988488.2  heat-stable enterotoxin receptor isoform X3

      UniProtKB/TrEMBL
      A0A2I2U408
      Conserved Domains (3) summary
      smart00044
      Location:788 → 979
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14044
      Location:480 → 750
      PK_GC-C; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-C
      cd06369
      Location:35 → 415
      PBP1_GC_C_enterotoxin_receptor; ligand-binding domain of the membrane guanylyl cyclase C
    Nucleotide Protein
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