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    NEFM neurofilament medium chain [ Sus scrofa (pig) ]

    Gene ID: 100625407, updated on 17-Aug-2024

    Summary

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    Official Symbol
    NEFMprovided by VGNC
    Official Full Name
    neurofilament medium chainprovided by VGNC
    Primary source
    VGNC:VGNC:111119
    See related
    Ensembl:ENSSSCG00000009648
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Also known as
    NEF3; NF-M
    Expression
    Restricted expression toward mixtures (RPKM 2.2) See more
    Orthologs
    human mouse all
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    Genomic context

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    See NEFM in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 14 NC_010456.5 (8955346..8967211)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 14 NC_010456.4 (10117172..10122612, complement)

    Chromosome 14 - NC_010456.5Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110256883 Neighboring gene ADAM metallopeptidase domain 7 Neighboring gene sodium/potassium-transporting ATPase subunit alpha-1 pseudogene Neighboring gene neurofilament light chain Neighboring gene uncharacterized LOC100521685

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables structural constituent of cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in neurofilament bundle assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in postsynaptic intermediate filament cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neurofilament medium polypeptide
    Names
    160 kDa neurofilament protein
    Neurofilament 3
    Neurofilament medium polypeptide
    Neurofilament triplet M protein
    neurofilament medium tail domain
    neurofilament, medium polypeptide

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010456.5 Reference Sscrofa11.1 Primary Assembly

      Range
      8955346..8967211
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005670439.3 → XP_005670496.2  neurofilament medium polypeptide isoform X1

      UniProtKB/TrEMBL
      A0A8D1NAK6, A0A8D1UI82, F1RJU6
      Related
      ENSSSCP00000010300.5, ENSSSCT00000010576.5
      Conserved Domains (3) summary
      pfam00038
      Location:100 → 411
      Filament; Intermediate filament protein
      pfam04732
      Location:10 → 74
      Filament_head; Intermediate filament head (DNA binding) region
      cl26511
      Location:271 → 843
      Neuromodulin_N; Gap junction protein N-terminal region

    2. XM_021074372.1 → XP_020930031.1  neurofilament medium polypeptide isoform X3

      UniProtKB/TrEMBL
      A0A5G2QW19
      Conserved Domains (4) summary
      pfam00038
      Location:100 → 411
      Filament; Intermediate filament protein
      pfam04732
      Location:10 → 74
      Filament_head; Intermediate filament head (DNA binding) region
      cl25865
      Location:682 → 779
      Trypan_PARP; Procyclic acidic repetitive protein (PARP)
      cl26511
      Location:606 → 835
      Neuromodulin_N; Gap junction protein N-terminal region

    3. XM_021074371.1 → XP_020930030.1  neurofilament medium polypeptide isoform X2

      UniProtKB/TrEMBL
      A0A5G2QW19
      Conserved Domains (4) summary
      pfam00038
      Location:100 → 411
      Filament; Intermediate filament protein
      pfam04732
      Location:10 → 74
      Filament_head; Intermediate filament head (DNA binding) region
      cl25865
      Location:682 → 779
      Trypan_PARP; Procyclic acidic repetitive protein (PARP)
      cl26511
      Location:606 → 835
      Neuromodulin_N; Gap junction protein N-terminal region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08552.2 GenPept UniProtKB/Swiss-Prot:P08552

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