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    HSD11B1 hydroxysteroid 11-beta dehydrogenase 1 [ Felis catus (domestic cat) ]

    Gene ID: 100529248, updated on 17-Aug-2024

    Summary

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    Official Symbol
    HSD11B1
    Official Full Name
    hydroxysteroid 11-beta dehydrogenase 1
    Primary source
    VGNC:VGNC:67654
    See related
    EnsemblRapid:ENSFCTG00005003866
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Felis catus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
    Orthologs
    human mouse all
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    Genomic context

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    See HSD11B1 in Genome Data Viewer
    Location:
    chromosome: F1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) F1 NC_058384.1 (33121402..33176474, complement)
    104 previous assembly Felis_catus_9.0 (GCF_000181335.3) F1 NC_018739.3 (35325909..35380838, complement)

    Chromosome F1 - NC_058384.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC109495657 Neighboring gene interferon regulatory factor 6 Neighboring gene chromosome F1 C1orf74 homolog Neighboring gene TRAF3 interacting protein 3 Neighboring gene uncharacterized LOC123382707 Neighboring gene laminin subunit beta 3 Neighboring gene G0/G1 switch 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Effect of hyperlipidemia on 11β-hydroxysteroid-dehydrogenase, glucocorticoid receptor, and leptin expression in insulin-sensitive tissues of cats. Sieber-Ruckstuhl NS, et al. Domest Anim Endocrinol, 2010 Nov. PMID 20688460

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. study concludes hyperlipidemia has a profound effect on 11beta-hydroxysteroid dehydrogenase expression and supports the connection between high lipid concentrations and tissue cortisol metabolism
      Title: Effect of hyperlipidemia on 11β-hydroxysteroid-dehydrogenase, glucocorticoid receptor, and leptin expression in insulin-sensitive tissues of cats.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 11-beta-hydroxysteroid dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables steroid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in steroid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    corticosteroid 11-beta-dehydrogenase isozyme 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference F.catus_Fca126_mat1.0 Primary Assembly

    Genomic

    1. NC_058384.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

      Range
      33121402..33176474 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006942809.4 → XP_006942871.1  corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X2

      Conserved Domains (1) summary
      cd05332
      Location:2 → 247
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

    2. XM_006942808.4 → XP_006942870.1  corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X1

      See identical proteins and their annotated locations for XP_006942870.1

      UniProtKB/TrEMBL
      M3X6E3
      Conserved Domains (1) summary
      cd05332
      Location:32 → 277
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

    3. XM_019821878.3 → XP_019677437.1  corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X2

      Conserved Domains (1) summary
      cd05332
      Location:2 → 247
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

    4. XM_019821876.3 → XP_019677435.1  corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X1

      UniProtKB/TrEMBL
      M3X6E3
      Conserved Domains (1) summary
      cd05332
      Location:32 → 277
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

    5. XM_045049143.1 → XP_044905078.1  corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X1

      UniProtKB/TrEMBL
      M3X6E3
      Conserved Domains (1) summary
      cd05332
      Location:32 → 277
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

    6. XM_019821875.3 → XP_019677434.1  corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X1

      UniProtKB/TrEMBL
      M3X6E3
      Conserved Domains (1) summary
      cd05332
      Location:32 → 277
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

    7. XM_019821874.3 → XP_019677433.1  corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X1

      UniProtKB/TrEMBL
      M3X6E3
      Related
      ENSFCTP00005006452.1, ENSFCTT00005010394.1
      Conserved Domains (1) summary
      cd05332
      Location:32 → 277
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

    8. XM_019821872.3 → XP_019677431.1  corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X1

      UniProtKB/TrEMBL
      M3X6E3
      Conserved Domains (1) summary
      cd05332
      Location:32 → 277
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

    9. XM_003999332.6 → XP_003999381.1  corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X1

      See identical proteins and their annotated locations for XP_003999381.1

      UniProtKB/TrEMBL
      M3X6E3
      Conserved Domains (1) summary
      cd05332
      Location:32 → 277
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

    10. XM_019821880.3 → XP_019677439.1  corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X4

      Conserved Domains (1) summary
      cl25409
      Location:32 → 221
      SDR; Short-chain dehydrogenases/reductases (SDR)

    11. XM_019821879.3 → XP_019677438.1  corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X3

      Conserved Domains (1) summary
      cl25409
      Location:32 → 220
      SDR; Short-chain dehydrogenases/reductases (SDR)
    Nucleotide Protein
    Heading Accession and Version

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