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    FGA fibrinogen alpha chain [ Oryctolagus cuniculus (rabbit) ]

    Gene ID: 100353616, updated on 8-Mar-2024

    Summary

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    Gene symbol
    FGA
    Gene description
    fibrinogen alpha chain
    See related
    Ensembl:ENSOCUG00000011239
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Oryctolagus cuniculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
    Orthologs
    human mouse all
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    Genomic context

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    See FGA in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) 15 NC_067388.1 (7917991..7925858, complement)

    Chromosome 15 - NC_067388.1Genomic Context describing neighboring genes Neighboring gene pleiotropic regulator 1 Neighboring gene fibrinogen beta chain Neighboring gene uncharacterized LOC127483251 Neighboring gene fibrinogen gamma chain Neighboring gene uncharacterized LOC127483252

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_067388.1 Chromosome 15 Reference UM_NZW_1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fibrinogen alpha genes: conservation of bipartite transcripts and carboxy-terminal-extended alpha subunits in vertebrates. Fu Y, et al. Genomics, 1995 Nov 1. PMID 8595905
    2. Carboxy-terminal-extended variant of the human fibrinogen alpha subunit: a novel exon conferring marked homology to beta and gamma subunits. Fu Y, et al. Biochemistry, 1992 Dec 8. PMID 1457396
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables extracellular matrix structural constituent IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in blood coagulation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in blood coagulation, common pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in fibrinolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of endothelial cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in platelet activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in platelet aggregation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of heterotypic cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of peptide hormone secretion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein polymerization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of fibrinogen complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fibrinogen alpha chain
    Names
    fibrinogen A-alpha chain
    fibrinogen alpha-E subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UM_NZW_1.0 Primary Assembly

    Genomic

    1. NC_067388.1 Reference UM_NZW_1.0 Primary Assembly

      Range
      7917991..7925858 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002716897.4 → XP_002716943.1  fibrinogen alpha chain

      UniProtKB/TrEMBL
      G1T0X2
      Related
      ENSOCUP00000009673.3
      Conserved Domains (3) summary
      cd00087
      Location:574 → 810
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
      pfam08702
      Location:50 → 186
      Fib_alpha; Fibrinogen alpha/beta chain family
      pfam12160
      Location:403 → 454
      Fibrinogen_aC; Fibrinogen alpha C domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P14461.1 GenPept UniProtKB/Swiss-Prot:P14461

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