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    rock1 Rho-associated, coiled-coil containing protein kinase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 100329779, updated on 14-Nov-2024

    Summary

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    Official Symbol
    rock1provided by ZNC
    Official Full Name
    Rho-associated, coiled-coil containing protein kinase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-100712-2
    See related
    Ensembl:ENSDARG00000058993 AllianceGenome:ZFIN:ZDB-GENE-100712-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable Rho-dependent protein serine/threonine kinase activity. Involved in epicardial cell to mesenchymal cell transition; negative regulation of adherens junction organization; and positive regulation of stress fiber assembly. Acts upstream of or within regulation of cytoskeleton organization. Predicted to be located in several cellular components, including bleb; centriole; and ruffle. Predicted to be active in cytoplasmic stress granule and cytoskeleton. Is expressed in forebrain and hindbrain. Orthologous to human ROCK1 (Rho associated coiled-coil containing protein kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See rock1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (2818643..2900825)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (2976746..3058926)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene myosin, light chain 13 Neighboring gene THO complex 1 Neighboring gene ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) Neighboring gene leucine-rich repeat-containing protein 38 Neighboring gene eukaryotic translation initiation factor 2B, subunit 5 epsilon

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The CCM1-CCM2 complex controls complementary functions of ROCK1 and ROCK2 that are required for endothelial integrity. Lisowska J, et al. J Cell Sci, 2018 Aug 13. PMID 30030370
    2. Actin-Cytoskeleton- and Rock-Mediated INM Are Required for Photoreceptor Regeneration in the Adult Zebrafish Retina. Lahne M, et al. J Neurosci, 2015 Nov 25. PMID 26609156, Free PMC Article
    3. Opticin Ameliorates Hypoxia-Induced Retinal Angiogenesis by Suppression of Integrin α2-I Domain-Collagen Complex Formation and RhoA/ROCK1 Signaling. Liu X, et al. Invest Ophthalmol Vis Sci, 2022 Jan 3. PMID 35006271, Free PMC Article
    4. Yolk syncytial layer formation is a failure of cytokinesis mediated by Rock1 function in the early zebrafish embryo. Chu LT, et al. Biol Open, 2012 Aug 15. PMID 23213468, Free PMC Article
    5. Erianin Controls Collagen-Mediated Retinal Angiogenesis via the RhoA/ROCK1 Signaling Pathway Induced by the alpha2/beta1 Integrin-Collagen Interaction. Li X, et al. Invest Ophthalmol Vis Sci, 2022 Jan 3. PMID 35060996, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Opticin Ameliorates Hypoxia-Induced Retinal Angiogenesis by Suppression of Integrin alpha2-I Domain-Collagen Complex Formation and RhoA/ROCK1 Signaling.
      Title: Opticin Ameliorates Hypoxia-Induced Retinal Angiogenesis by Suppression of Integrin α2-I Domain-Collagen Complex Formation and RhoA/ROCK1 Signaling.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in epicardial cell to mesenchymal cell transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of adherens junction organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of stress fiber assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in bleb IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ruffle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rho-associated protein kinase 1
    Names
    rho-associated coiled-coil domain-containing protein kinase 1
    NP_001243563.1
    XP_021334267.1
    XP_068078897.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256634.1 → NP_001243563.1  rho-associated protein kinase 1

      See identical proteins and their annotated locations for NP_001243563.1

      Status: PROVISIONAL

      Source sequence(s)
      JN416777
      UniProtKB/TrEMBL
      A0A0R4IVY5, E7F9X9, H6U1H5
      Related
      ENSDARP00000141411.2, ENSDART00000163587.2
      Conserved Domains (7) summary
      cd11639
      Location:493 → 558
      HR1_ROCK1; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 1
      smart00220
      Location:78 → 340
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG1196
      Location:426 → 1105
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00029
      Location:1234 → 1288
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01242
      Location:1124 → 1230
      PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
      cd05622
      Location:4 → 408
      STKc_ROCK1; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 1
      pfam08912
      Location:952 → 1017
      Rho_Binding; Rho Binding

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      2818643..2900825
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021478592.2 → XP_021334267.1  rho-associated protein kinase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PRV2
      Conserved Domains (4) summary
      cd00029
      Location:1234 → 1288
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01242
      Location:1124 → 1230
      PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
      cd05622
      Location:4 → 408
      STKc_ROCK1; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 1
      cl25732
      Location:426 → 1105
      SMC_N; RecF/RecN/SMC N terminal domain

    2. XM_068222796.1 → XP_068078897.1  rho-associated protein kinase 1 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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