mib1 MIB E3 ubiquitin protein ligase 1 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: mib1provided by Xenbase
Official Full Name: MIB E3 ubiquitin protein ligase 1provided by Xenbase
Primary source: Xenbase:XB-GENE-1001395
See related: Ensembl:ENSXETG00000003146 AllianceGenome:Xenbase:XB-GENE-1001395
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: mib; zzz6; dip-1; zzank2; mindbomb
Summary: Predicted to enable ubiquitin-protein transferase activity and zinc ion binding activity. Predicted to act upstream of or within Notch signaling pathway and protein ubiquitination. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in left ventricular noncompaction. Orthologous to human MIB1 (MIB E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	6	NC_030682.2 (108583964..108646412)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	6	NC_030682.1 (93516116..93576279)

Chromosome 6 - NC_030682.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Notch signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase MIB1

Names: mind bomb; mindbomb E3 ubiquitin protein ligase 1; mindbomb homolog 1

NP_001123407.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001129935.1 → NP_001123407.1 E3 ubiquitin-protein ligase MIB1

See identical proteins and their annotated locations for NP_001123407.1

Status: PROVISIONAL

Source sequence(s)

BC167461

UniProtKB/TrEMBL

B3DLI6, F6QQD4, F6YFN5

Related

ENSXETP00000006826.4, ENSXETT00000006826.5

Conserved Domains (9) summary

PHA03095
Location:439 → 710

PHA03095; ankyrin-like protein; Provisional

cd02339
Location:83 → 127

ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...

sd00045
Location:464 → 527

ANK; ANK repeat [structural motif]

cd16724
Location:818 → 854

RING1-HC_MIB1; RING finger 1, HC subclass, found in mind bomb 1 (MIB1) and similar proteins

cd16725
Location:865 → 901

RING2-HC_MIB1; RING finger 2, HC subclass, found in mind bomb 1 (MIB1) and similar proteins

cd16727
Location:962 → 1003

RING3-HC_MIB1; RING finger 3, HC subclass, found in mind bomb 1 (MIB1) and similar proteins

pfam06701
Location:154 → 218

MIB_HERC2; Mib_herc2

pfam12796
Location:670 → 770

Ank_2; Ankyrin repeats (3 copies)

pfam18346
Location:333 → 397

SH3_15; Mind bomb SH3 repeat domain