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    sufu SUFU negative regulator of hedgehog signaling [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 100170148, updated on 4-Nov-2024

    Summary

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    Official Symbol
    sufuprovided by Xenbase
    Official Full Name
    SUFU negative regulator of hedgehog signalingprovided by Xenbase
    Primary source
    Xenbase:XB-GENE-479289
    See related
    Ensembl:ENSXETG00000015219 AllianceGenome:Xenbase:XB-GENE-479289
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Also known as
    Xsufu; sufuh; sufuxl; pro1280
    Summary
    Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Joubert syndrome 32; familial meningioma; medulloblastoma; and nevoid basal cell carcinoma syndrome 2. Orthologous to human SUFU (SUFU negative regulator of hedgehog signaling). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See sufu in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 7 NC_030683.2 (29279826..29299961, complement)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 7 NC_030683.1 (21050578..21070790, complement)

    Chromosome 7 - NC_030683.2Genomic Context describing neighboring genes Neighboring gene ARF like GTPase 3 Neighboring gene tripartite motif containing 8 Neighboring gene uncharacterized LOC116412022 Neighboring gene ARP1 actin related protein 1 homolog A Neighboring gene major facilitator superfamily domain containing 13A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    suppressor of fused homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001129915.1 → NP_001123387.1  suppressor of fused homolog

      See identical proteins and their annotated locations for NP_001123387.1

      Status: PROVISIONAL

      Source sequence(s)
      BC167609
      UniProtKB/TrEMBL
      A0A6I8S7Q8, B3DLW7
      Related
      ENSXETP00000092843.2, ENSXETT00000077399.2
      Conserved Domains (2) summary
      pfam12470
      Location:243 → 463
      SUFU_C; Suppressor of Fused Gli/Ci N terminal binding domain
      pfam05076
      Location:53 → 229
      SUFU; Suppressor of fused protein (SUFU)

    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030683.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      29279826..29299961 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_012966142.3 → XP_012821596.1  suppressor of fused homolog isoform X1

      UniProtKB/TrEMBL
      A0A8J0SQ36
      Conserved Domains (2) summary
      pfam05076
      Location:57 → 229
      SUFU; Suppressor of fused protein (SUFU)
      pfam12470
      Location:242 → 462
      SUFU_C; Suppressor of Fused Gli/Ci N terminal binding domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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